A5038546951- Acute Myeloid Leukemia Research
- PARP inhibition in cancer therapy
- Cancer Genomics and Diagnostics
- Developmental Biology and Gene Regulation
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Hedgehog Signaling Pathway Studies
- COVID-19 Clinical Research Studies
- Genomics and Phylogenetic Studies
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Integrated Circuits and Semiconductor Failure Analysis
- COVID-19 epidemiological studies
- Cancer-related gene regulation
- Vaccine Coverage and Hesitancy
- COVID-19 and Mental Health
- Renal and related cancers
- Myeloproliferative Neoplasms: Diagnosis and Treatment
European Institute of Oncology
2007-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2024
Genomics (United Kingdom)
2021
Center for Genomic Science
2012-2017
Italian Institute of Technology
2012-2017
Tumori Foundation
2002
Fondazione IRCCS Istituto Nazionale dei Tumori
1999-2001
University of Cincinnati Medical Center
2000-2001
Sabin Vaccine Institute
2001
Target (United States)
2000
Notch genes encode a family of transmembrane proteins that are involved in many cellular processes such as differentiation, proliferation, and apoptosis. Although it is well established all four can act oncogenes, the mechanism by which transform cells remains unknown. Previously, we have shown transformation RKE be conditionally induced hormone activation Notchic-estrogen receptor (ER) chimeras. Using this inducible system, show Notchicactivates transcription cyclin D1 gene with rapid...
Abstract Misregulation of the Wnt signaling pathway has been linked to many human cancers including colon carcinoma and melanoma. The primary mediator oncogenic effects is β-catenin. Accumulation nuclear β-catenin transcription activation lymphoid enhancer factor 1 (LEF1)/T-cell (TCF) target genes underlie activity. However, mechanism β-catenin–mediated transcriptional remains poorly understood. In this study, we identified Mastermind-like (Maml1), which thought be a specific coactivator for...
Despite the recent progress that has been made in understanding and treatment of acute lymphoblastic leukemia (ALL), outcome is still dismal adult ALL cases. Several studies solid tumors identified high expression WEE1 kinase as a poor prognostic factor reported its role cancer-conserving oncogene protects cancer cells from DNA damage. Therefore, targeted inhibition emerged rational strategy to sensitize antineoplastic compounds, which we evaluate this study. The effectiveness selective...
Abstract Background Contradictory results were reported on the role of school closure/reopening overall SARS-CoV-2 transmission rate, as well which kind and level mitigation measures implemented in schools may be effective limiting its diffusion. Some recent studies reassuring, showing that opening did not increase community spread, although teachers families are worried about high class density. On other hand, distance learning was associated with a negative impact learning, sociability...
The Notch signal transduction pathway is a highly conserved regulatory system that controls multiple developmental processes. We have established an erythroleukemia cell model to study how regulates fate and erythroleukemic differentiation. K562 HEL cells expressed the Notch-1 receptor ligand Jagged-1. stable expression of constitutively active intracellular domain (NIC-1) in inhibited erythroid without affecting megakaryocytic maturation. Expression antisense induced spontaneous Suppression...
The E3 ubiquitin ligase (E3) WWP1 is an oncogenic factor implicated in the maintenance of different types epithelial cancers. role WW domain-containing protein 1 (WWP1) haematological neoplasms remains unknown. Acute myeloid leukaemia (AML) characterized by expansion malignant cells blocked at stages differentiation. Here we report that expression significantly augmented a large cohort primary AML patients and cell lines, compared with haematopoietic from healthy donors. We show inactivation...
The correlation between immune responses and protection from SARS-CoV-2 infections its duration remains unclear. We performed a sanitary surveillance at the European Institute of Oncology (IEO) in Milan over 17 months period. Pre-vaccination, 1,493 participants, we scored 266 (17.8%) 8 possible reinfections (3%). Post-vaccination, identified 30 2,029 vaccinated individuals (1.5%). report that probability infection post-vaccination is i) significantly lower compared to natural infection, ii)...
The existing treatments to cure acute leukemias seem be nonspecific and suboptimal for most patients, drawing attention the need of new therapeutic strategies. In last decade anticancer potential poly ADP-ribose polymerase (PARP) inhibitors became apparent now several PARP are being developed treat various malignancies. So far, usage has been mainly focused on treatment solid tumors not too much about their efficacy is known. this study we test, first time leukemic cells, a combined therapy...
Abstract Aberrant DNA methylation at CpG dinucleotides is a cancer hallmark that associated with the emergence of resistance to anti treatment, though molecular mechanisms and biological significance remain elusive. Genome scale maps by currently used methods are based on chemical modification best suited for analyses rich regions (CpG islands). We report first high coverage whole-genome map in using long read nanopore technology, which allows simultaneous DNA-sequence -methylation native...
Abstract Inhibitors of poly(ADP‐ribose) polymerase (PARPi) are increasingly employed as salvage therapy in epithelial ovarian cancer (EOC), but cytotoxic drug exposure along with PARP inhibition may favor development hematological disorders. In our study, 182 women EOC treated PARPi, 16 (8.7%) developed therapy‐related myeloid neoplasms (t‐MNs), 12 cases myelodysplasia and 4 acute leukemia. All experienced persistent cytopenia after PARPi discontinuation. Seven patients had del(5q)/−5 and/or...
We investigated the occurrence and management of therapy-related hematological disorders (tr-HDs) in women with epithelial ovarian cancer (EOC) exposed to poly-ADP-ribose polymerase inhibitors (PARPi), after previous chemotherapy. analyzed 130 consecutive EOC patients treated PARPi at European Institute Oncology, Milan. In line literature, overall survival entire population was 37% 5.5 years (89% were advanced stages). Cell blood counts collected prior start PARPi, each new cycle monthly...
We have previously reported on the isolation and chromosomal mapping of a novel human gene (SEL1L), which shows sequence similarity to sel-1, an extragenic suppressor C. elegans. sel-1 functions as negative regulator lin-12 activity, latter being implicated in control diverse cellular differentiation events. In present study we compare expression patterns SEL1L TAN-1, ortholog normal neoplastic cells. found that, whereas both genes are expressed fetal tissues at similar levels, they...
Venetoclax is a potent, orally available, small molecule B-cell lymphoma 2 (Bcl-2) Homology 3 (BH3) mimetic, capable of promoting apoptosis through selective inhibition pro‐survival protein BCL2...
Whether Clonal Hematopoiesis (CH) represents a risk factor for severity of the COVID-19 disease remains controversial issue. We report first high- sensitivity analysis CH in patients (threshold detection at 0.5% vs 1 or 2% previous studies). analyzed 24 admitted to ICU (COV-ICU) and 19 controls, including healthy subjects asymptomatic SARS-CoV2-positive individuals. Despite significantly higher numbers mutations identified (80% with <2% variant allele frequency, VAF), we did not find...