A5042320241- Helicobacter pylori-related gastroenterology studies
- Veterinary medicine and infectious diseases
- Effects of Radiation Exposure
- Thyroid Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Gene Regulatory Network Analysis
- Osteoarthritis Treatment and Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Inflammatory mediators and NSAID effects
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- RNA and protein synthesis mechanisms
- Intramuscular injections and effects
- Lipoproteins and Cardiovascular Health
- Occupational and environmental lung diseases
- Mycobacterium research and diagnosis
- RNA Research and Splicing
- Biomarkers in Disease Mechanisms
- Microtubule and mitosis dynamics
- Evolution and Genetic Dynamics
- Carcinogens and Genotoxicity Assessment
- Bone health and treatments
- Gastric Cancer Management and Outcomes
- BRCA gene mutations in cancer
- Bone Metabolism and Diseases
ITMO University
2023-2025
Moscow Power Engineering Institute
2024
Moscow Aviation Institute
2024
S. M. Kirov Military Medical Academy
2018-2022
Volgograd State Medical University
2020-2021
Ministry of Emergency Situations
2006-2018
Nikiforov Russian Center of Emergency and Radiation Medicine
2006-2018
Pushkin Leningrad State University
2015
Background: The global spread of Strongyloides stercoralis has escalated public health concerns, affecting over 600 million people worldwide. rise in migration heightened the risk transmission, underscoring urgent need for effective treatment options. Objective: This study aimed to investigate ten polyphenolic phytochemicals derived from Mangifera indica as potential alternatives combat S. stercoralis. Methods: efficacy these compounds was evaluated using computational techniques, including...
RNA-binding proteins (RBPs) play a crucial role in RNA metabolism, influencing processes like transcription, splicing, transport, and stability, as well cell proliferation immune responses. Their links to diseases, such cancer neurological disorders, make them prime candidates for therapeutic targeting. Among these, heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) is notable its regulation of gene expression involvement telomere maintenance DNA repair. Its activity various cancers...
Abstract: Genome instability is a key driver of malignant progression in cancer and char-acterized by chromoanagenesis, including spontaneous events, such as chromothripsis, chromoanasynthesis, chromoplexy. These genome catastrophes create the heterogeneity necessary for tumor cells to adapt, evolve, resist therapy. Ergodic anticancer therapy rep-resents novel strategy targeting stem manipulating their chaos. Two approaches have been proposed: ergodynamic (EDAT), which en-hances chaos beyond...
Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a pivotal player in m6A recognition, RNA metabolism, and antiviral responses. In the context of cancer, overexpression hnRNPA2/B1, abnormal levels, depositions are evident. This study focuses on two significant nonsynonymous single nucleotide polymorphisms (nsSNPs) within namely, F66L E92K. Our structural analyses reveal decreased stability these mutants, with E92K being predicted to undergo destabilizing post-translational...
In clinical practice, the metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear which component of (obesity, inflammation, hyperglycemia, or insulin resistance) has strongest inhibitory effect on stem cells involved in beta cell regeneration. This makes it challenging develop effective treatment options for complications such as our study, experiments were performed male C57BL/6 mice where disorders have been introduced experimentally by a combination...
During the progression of cancer cells, degree genome instability increases leading to chaos in populations malignant cells. While normally is associated with er-godicity, i.e., state when time averages relevant parameters equal their phase space averages, situation propagation more complex. Chromothripsis, a catastrophic massive genomic rearrangement, observed many types increased mu-tation rates. We present an entropic model and ergodicity experimental evidence that increasing beyond...
Radiation exposure leads to a large number of victims who seek medical help in the first hours. To provide care, it is necessary correctly establish fact and dose radiation by bioindication biodosimetry methods. Lymphocytes containing nuclear anomalies are easily detected cells peripheral blood suitable as objects case radioactive people. Among these we distinguish micronuclei, “tailed” nuclei, nucleoplasmatic bridges, dumbbell-shaped etc. This review observes main types lymphocytes light...
During the progression of some cancer cells, degree genome instability may increase, leading to chaos in populations malignant cells. While normally is associated with ergodicity, i.e., state when time averages relevant parameters are equal their phase space averages, situation propagation more complex. Chromothripsis, a catastrophic massive genomic rearrangement, observed many types cancer, increased mutation rates. We present an entropic model and ergodicity experimental evidence that...
Helicobacter pylori eradication therapy can be considered effective if the result of its implementation is removed including all roots and rootlets from which surviving H. repopulate in gastric mucosa. One reasons for ineffectiveness continuous presence viable coccoid forms oral cavity. Therefore, anti-Helicobacter should supplemented by sanitation cavity.The objective this study to determine frequency occurrence mucosa cavity patients with chronic periodontitis or gastritis using...
Antibiotics are known to be effective in treating bacterial infectious disease. Changes microflora and mucosal dysbiosis may take place after antibiotic treatment. We investigated this research the effect of anti-Helicobacter pylori treatment (AHT) on local immunity female genital tract.The study identified levels cytokines IL-8 TNF-α vaginal secretion a group patients with Helicobacter-associated acid-related diseases who were or not treated antibiotics against Helicobacter Pylori.Research...
The survey of the literature devoted to genetic epidemiology keratoconus and also principles markers search showed predisposition this disease suitable for screening test in course certification population. It was revealed that hereditary keratokonus caused by gene mutations, encoding cellular cycle metabolism keratocytes regulating activity tissue proteolytic enzymes, mechanisms natural detoxification. Genes associated with are characterized allelic variation multiple mutations taking...
Авторы анализируют свой опыт лечения открытых и закрытых травм печени, вопросы диагностики, информативность инвазивных неинвазивных методов диагностики делятся накопленным опытом лечения. Используя современный алгоритм авторам удалось снизить летальность до 8,8%. The authors analyze their experience in the treatment of open and closed liver injuries, diagnostic issues, informative value invasive non-invasive methods share treatment. Using a modern algorithms, managed to reduce mortality rate 8.8%.
During historical research into the Russian physician Nikolay Ivanovich Pirogov (1810–1881) and his relation to Dutch scientists in shaping medical science, access was allowed first author of this manuscript fundamental library Military Medical Academy named S. M. Kirov. The is one oldest libraries Russia founded by Pavel Zakharyevich Condoidi, a pupil scientist Herman Boerhaave. Condoidi succeeded nephew Boerhaave, Kaau-Boerhaave after death as director Meditsinskaya Kantselyariya (Ministry...
The research of degree incidence genomic changes (of micronuclei) in mucous cells gastric superficial-foveolar epithelium contaminated and not stomach was made. Histopathological micronuclei helicobacter made biopsy specimen patients with diagnosis-chronical gastritis (ICD-10K29.3) group who lived radiation areas groups people, had no factors influence anamnesis. People, the areas, whose infected by Helicobacter pylori, highest frequency micronuclei. In from HP-associated appearance...
<h3>Background</h3> In recent years, much attention is paid to the study of relationship between degenerative joint diseases and adipokines. It supposed that imbalance adipokines may influence on course osteoarthritis (OA). <h3>Objectives</h3> To clinical pathogenetic significance leptin determination in serum OA patients. <h3>Methods</h3> We observed 130 patients aged 34 78 years (78 women 52 men). The control group consisted 25 20 men 26 58 with no complaints pain joints, without...
Background. Fallout from Chernobyl accident was primarily to iodine radioisotopes, with Iodine-131 (I-131) being the most predominant. Radioiodines accumulated following could induce pathologic changes in thyrocytes. Internuclear chromatine bridges and ‘‘tailed’’nuclei - broken bridge fragments are considered like cytopathological effects of radiation exposure as these abnormalities formed dicentric chromosomes, which established markers exposure. Objective. To test possibility that...