Won-Chul Lee
A5102006124- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Lung Cancer Research Studies
The University of Texas MD Anderson Cancer Center
2018-2020
Abstract Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the in lungs patients with NSCLC. Here, we report repertoire analysis cohort 236 early-stage NSCLC patients. attributes are associated clinicopathologic features, mutational and immune landscape. A considerable proportion most prevalent also uninvolved tumor-adjacent appear specific shared background mutations or viral...
Intra-tumor heterogeneity may be present at all molecular levels. Genomic intra-tumor the exome level has been reported in many cancer types, but comprehensive gene expression not well studied. Here, we delineated by exploring profiles of 35 tumor regions from 10 non-small cell lung tumors (three or four regions/tumor), including adenocarcinoma, squamous carcinoma, large-cell and pleomorphic carcinoma lung. Using Affymetrix Gene 1.0 ST arrays, generated data for every sample. Inter-tumor was...