A5076686036- Open Education and E-Learning
- French Language Learning Methods
- Educational Tools and Methods
- Information Technology and Learning
- Influenza Virus Research Studies
- Intelligent Tutoring Systems and Adaptive Learning
- Respiratory viral infections research
- Educational Games and Gamification
- Teaching and Learning Programming
- Innovative Teaching and Learning Methods
- Mathematics Education and Teaching Techniques
- Chemistry and Chemical Engineering
- Social Sciences and Governance
- Immune Response and Inflammation
- Online Learning and Analytics
- Semantic Web and Ontologies
- Linguistics and Discourse Analysis
- Education, sociology, and vocational training
- History and advancements in chemistry
- Biosimilars and Bioanalytical Methods
- COVID-19 epidemiological studies
- Mathematics, Computing, and Information Processing
- Advanced Text Analysis Techniques
- SAS software applications and methods
- Education and Digital Technologies
University of Geneva
2022-2024
Roche (Switzerland)
2021-2023
Laboratoire de Didactique André Revuz
2021-2022
Université Paris Cité
2022
Délégation Paris 7
2022
Laboratoire d'Informatique de Grenoble
2018-2020
Université Grenoble Alpes
2020
Novartis (Switzerland)
2017
Institut Français de l'Éducation
2015
To aid understanding of the effect antiviral treatment on population-level influenza transmission, we used a novel pharmacokinetic–viral kinetic transmission model to test correlation between nasal viral load and infectiousness, evaluate impact that timing with antivirals oseltamivir or baloxavir has transmission. The was run under three candidate profiles whereby infectiousness assumed be proportional titer natural-scale, log-scale, dose–response model. Viral in presence absence were...
Abstract Baloxavir marboxil is an endonuclease inhibitor indicated for the treatment of influenza in patients ≥12 years. No data exist Chinese global studies. This randomized, open‐label, phase I study evaluated pharmacokinetics (PK) and safety baloxavir healthy volunteers was used to anticipate efficacy patients. Patients received a single oral dose (40 or 80 mg [1:1]). Serial blood samples were collected predose at various timepoints up 14 days postdose. acid plasma concentrations...
ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
This article presents the design of a theoretical and methodological framework for didactic learning environment: platform in mathematics cycle 4 students (aged 12 to 15). We cross several approaches build models their computer representation: model knowledge involved platform, learner's reasoning, paths adapted student's needs. illustrate this approach on two themes from mathematical domains, solving first-degree equations algebra construction triangles geometry.
Our work is part of a broader research project on how French teachers and trainers can appropriate learning games dedicated to computer science programming.To foster this appropriation, we aim implement meta-design approach that favours instrumental genesis.In article, describe our review selection identify whether they are suitable for approach.We introduce set rather generic reusable criteria characterize the instrumentalization serious games.With these thoroughly 10 among 48...
Baloxavir marboxil, the prodrug of baloxavir acid, is an anti-influenza antiviral. Here, a pharmacokinetics-time to alleviation symptoms (PK-TTAS) model was developed and used (I) characterize PK-TTAS relationship, (II) quantify impact covariates, (III) predict TTAS in different ethnic groups. Data from 1781 otherwise-healthy (OwH) or high-risk (HR) patients included phase II (JapicCTI-153090) III studies (NCT02954354 NCT02949011) were used; received either placebo oral marboxil. The natural...
Abstract Background Characterization of gantenerumab systemic exposure is important to inform dose selection and understand the factors that influence pharmacokinetics (PK), such as participant‐ or study‐specific characteristics, safety efficacy treatment. Method Gantenerumab PK following subcutaneous administration was investigated in multiple clinical studies, including single‐dose studies healthy participants with dense sampling multiple‐dose living AD (pwAD) sparse sampling. An...
Plus grande famille parmi les additifs, retardateurs de flamme (FR) jouent un rôle essentiel dans la sécurité des produits notre vie quotidienne et sur lieu travail. Une majorité plastiques, textiles autres matériaux naturels ou synthétiques sont en effet nature combustible, bon nombre d'entre eux doivent être additivés afin d'être conformité avec réglementation normes sectorielles. Si personne ne conteste le fait que FR sauvent vies, préservent biens réduisent gravité conséquences...
RésuméNous présentons dans cette contribution un modèle de description ressources type exercices mathématiques. Ce permet, à partir d’éléments liés aux tâches et ostensifs mobilisés l’exercice, d’en obtenir une fondée sur des critères didactiques. Le travail réalisé donne rôle central praxéologique référence sa représentation informatique proposée le cadre T4TEL. Il permet calculer, d’une initiale basée les objets ostensifs, plusieurs informations complémentaires la ressource afin...
There are many learning games related to the theme of programming and computational thinking (CT) that exist nowadays. However, main problem currently in France is teachers lack training teach K-12 learners modern computer concepts. Teachers understand competencies referential but not comfortable with don’t know how develop teaching sessions for these competencies. Our proposition is: a game (LG) driven by will assist learners. objective help appropriate on CT. To do this, we conducted an...