A5023141572- Intravenous Infusion Technology and Safety
- Healthcare Technology and Patient Monitoring
- Advanced Radiotherapy Techniques
- Embedded Systems and FPGA Applications
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Electrohydrodynamics and Fluid Dynamics
- Patient Safety and Medication Errors
- Cardiac Arrhythmias and Treatments
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Security and Verification in Computing
- Quality and Safety in Healthcare
- Electrical and Bioimpedance Tomography
- Hemodynamic Monitoring and Therapy
- Central Venous Catheters and Hemodialysis
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Anesthesia and Sedative Agents
Medisch Centrum Haaglanden
2019-2023
University Medical Center Utrecht
2015-2017
Utrecht University
2015
University Medical Center Groningen
2012
University of Groningen
2012
To assess the sensitivity of detection and accuracy volumetry by manual semi-automated quantification artificial pulmonary nodules in an anthropomorphic thoracic phantom on low-dose CT.Fifteen spherical (diameter 3, 5, 8, 10 12 mm; CT densities -800, -630 +100 HU) were randomly placed inside phantom. The was examined 16- 64-row multidetector with a protocol. Two independent blinded observers screened for nodules. Nodule diameter measured manually, volume calculated. For solid (+100 HU), also...
Abstract Multi-infusion therapy, in which multiple pumps are connected to one access point, is frequently used patient treatments. This practice known cause dosing errors following setpoint changes the drug concentrations that actually enter patients. Within Metrology for Drug Delivery Project, we analyzed and quantified two main physical phenomena leading these errors: “push-out” effect system mechanical compliance. We compared of a three-pump with infusion sets, both without anti-reflux...
Abstract For critical drug delivery, it is important to have a constant and well-known infusion rate delivered by the complete set-up (pump, tubing, accessories). Therefore, various delivery devices accessories were tested in this article terms of their accuracy, start-up delay, response time, dependency on viscosity. These measurements performed as part European funded research project MeDD. The obtained results show that accuracy flow accessory depended, especially for low rates. Viscosity...
In this paper, a new method is presented that combines mechanical compliance effects with Poiseuille flow and push-out ("dead volume") in one single mathematical framework for calculating dosing errors multi-infusion set-ups. contrast to existing numerical methods, our produces explicit expressions illustrate the dependencies of on hardware parameters pump rate settings.Our approach uses Z-transform model contents catheter, after implementation Mathematica (Wolfram), are produced...
Abstract Introduction Infusion therapy is challenging and dosing errors may occur due to physical phenomena related the infusion hardware, despite use of accurate syringe pumps. These typically after interventions, such as exchange a syringe. We aimed characterize quantify in relation properties hardware. Methods An analytical simulation model was used investigate two different protocols (variations). Each protocol involved fast pump, containing non-critical medication, slow critical drug....
The purpose was to compare linac-based stereotactic radiosurgery and hypofractionated radiotherapy plan quality of automated planning, intensity modulated (IMRT) manual dynamic conformal arc (DCA) plans as well single- multiple-isocenter techniques for multiple brain metastases (BM). For twelve patients with four ten BM, seven non-coplanar were created: a manually planned DCA separate isocenter each metastasis, single-isocenter IMRT plan, an automatically generated volumetric (VMAT) three or...
Abstract Infusion therapy is widely used in hospitals. It well known that medication errors constitute one of the highest risks to patient safety, leading numerous adverse events concerning incorrect application infusion technology. Both clinical practice and
Purpose In order to find the correct final position of tip a central venous catheter, we have developed new electric method (the Proximity Cardiac Motion (PCM) method), designed work in tandem with existing ECG-based method. Methods A small, patient-safe, high-frequency current is fed through catheter (via saline-filled lumen or stylet). Simultaneously, resulting voltage measured by two electrodes on frontal thoracic skin. The hence functions as source inside vasculature. cardiac motion...
A 67-year critically ill patient suffered from a hypertensive crisis (200 mm Hg) because of norepinephrine overdose. The overdose occurred when the clinician exchanged an almost-empty syringe and pump repeatedly reported error. We hypothesized that object between plunger driver may have caused exertion too much force on syringe. Testing this hypothesis in vitro showed significant peak dosing errors (up to +572%) but moderate (0.07 mL, +225%) if clamp was used intravenous infusion line large...