Surgical site infections are the second most common type of adverse events occurring in hospitalized patients, whereas an estimated 40-60% these thought to be preventable. Choice regimen, administration timing or duration antibiotic prophylaxis is reported inappropriate approximately 25-50% cases. We tried evaluate pattern for surgical a teaching hospital.This study was conducted at general surgery and orthopedic wards hospital affiliated with Mazandaran University Medical Sciences. The...

Sucralfate has been used for the prevention and treatment of radiotherapy- chemotherapy-induced stomatitis mucositis in a number studies, but results are contradictory. To answer such discrepancies, present study was designed to evaluate efficacy sucralfate mouthwash 5-fluorouracil (5-FU)-induced oral patients with gastrointestinal malignancies. Patients cancers receiving 5-FU-based chemotherapy regimens were included this randomized, blinded, controlled trial randomly allocated either...

Abstract This study aimed to determine the levels of free androgen index (FAI) and its association with oxidative stress insulin resistance (IR) in patients polycystic ovary syndrome (PCOS). cross-sectional was performed on 160 women aged 18–45 years, visiting gynecology clinics Urmia northwestern Iran during 2020–2021 who were diagnosed PCOS exhibited one four phenotypes PCOS. All participants underwent clinical examinations, paraclinical tests, ultrasounds. FAI cut-off point considered be...

<b>Objective:</b> Tadalafil is a selective Phosphodiesterase-5 inhibitor that has been reported to have vasodilatory and antiproliferative effects on the pulmonary artery. In this study we evaluated safety efficacy of oral tadalafil in children with arterial hypertension (PAH). <b>Methods:</b> This open label study, prospective interventional was carried out 25 known patients aged 2 month–5 years 3 medical centers Iran, between March 2013–Jun 2014. suspension administrated at 1 mg/kg daily...

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. This affects 6-15% of women childbearing age worldwide. It diagnosed with hyperandrogenism, polycystic ovaries, and chronic anovulation insulin resistance. study aimed to assess prevalence resistance (IR) 4 phenotypes PCOS, its relationship demographic, clinical, paraclinical individual characteristics a sample Iranian PCOS patients.This particular cross-sectional investigation involved 160 female participants,...

The inappropriate use of antibiotics remains the primary factor in antimicrobial drug resistance. In this study, we evaluate meropenem surgical/medical wards Imam Khomeini Tertiary Referral Hospital, Sari, Iran.This retrospective observational study was used to assess rational meropenem. conducted by reviewing medical records 100 admitted patients who received during March 2013 January 2014.Meropenem prescribed most frequently Intensive Care Unit (22%), and pneumonia common diagnosis (35%)....

Background . Levothyroxine is commonly used in the treatment of patients with hypothyroidism. most often administered morning, on an empty stomach, order to increase its oral absorption. However, many have difficulties taking levothyroxine morning. Aim The aim this study was evaluating effect changing administration time from before breakfast dinner serum levels TSH and T4. Subjects Methods Fifty between 18 75 years old hypothyroidism were included randomly divided into two groups. Each...

The aim of this study was to evaluate the effectiveness topical sucralfate in management pressure ulcer (PU) hospitalized patients.Forty patients with stage II PU were included prospective, double-blind, randomized, placebo-controlled trial and randomly divided into 2 groups receiving either gel or placebo, on a daily basis. visited every day for 14 days, evaluated using Pressure Ulcer Scale Healing (PUSH) changes measured scores over time used as an indicator wound healing.There no...

Abstract Background Drug-laboratory (lab) interactions (DLIs) are a common source of preventable medication errors. Clinical decision support systems (CDSSs) promising tools to decrease such errors by improving prescription quality in terms lab values. However, alert fatigue counteracts their impact. We aimed develop novel user-friendly, evidence-based, clinical context-aware CDSS nephrologists about DLIs clinically important values prescriptions kidney recipients . Methods For the most...

In this study the intensity and duration of analgesic effect diclofenac Na - Eudragit(®) RS100 solid dispersion nanoparticles were evaluated by using formalin test in rats.The animals received different formulations subsequently 50 μl solution (2.5%) was injected subcutaneously right paws after 1 h, 2 h 3 h. The paw licking behavior then two phases. A dose 20 mg/kg pure powder determined as effective dose.In first phase, term reduced time, no significant differences found any groups compared...

In recent years' medical management with misoprostol is an effective alternative to surgical evacuation. But there a dearth of evidence reveal the effectiveness different routes and satisfaction rate among patients treated these routes.

The goal of the present study was to evaluate efficacy topical tramadol in management knee osteoarthritis pain. Sixty patients with moderate severe pain were enrolled. Patients randomized receive 5% or placebo along oral diclofenac 100 mg/day. They instructed apply ointment every 12 h on for three weeks. To control breakthrough pain, allowed take acetaminophen up 650 mg per day. measured variables Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Visual Analog Scale...

Objective: Chronic kidney disease (CKD) is a pervasive health issue associated with various complications, including cognitive impairment and depression among patients undergoing hemodialysis. This study aimed to assess the impact of melatonin on function in hemodialysis patients. Method : A randomized, double-blinded, placebo-controlled clinical trial was conducted 50 patients, half receiving 3 mg daily other placebo for two months. Depression were evaluated using Beck Inventory (BDI)...

Background: Inappropriate use of broad-spectrum antibiotics has contributed to the emergence resistant microorganisms, increased treatment costs, morbidity and mortality, drug toxicity, prolonged hospitalization period. Determining epidemiology antibiotic resistance in various hospital wards allows for more precise selection setting. This study evaluated pattern a antibiotic, Piperacillin/tazobactam, Imam Khomeini, referral teaching Urmia, Iran. Methods: All hospitalized patients who were...

Background: Albumin is generally used in hypovolemic conditions and due to its high cost complicated manufacturing process, appropriate use a vital issue be considered. The aim of this study was evaluate the pattern prescription Imam Khomeini teaching hospital Urmia, Iran. Methods: This carried out between December 2014 2015 hospital, affiliated Urmia University Medical Sciences, using pre-designed forms covering demographic data clinical laboratory information that completed by educated...

Introduction: Drug utilization evaluation (DUE) studies are designed to evaluate the rational use of drugs. Our purpose in this study is pattern Imipenem, a broad-spectrum antibiotic used different parts Imam Khomeini and Taleghani Educational Center Urmia. Method material: This cross-sectional retrospective study. The was conducted by reviewing medical records 200 admitted patients who received Imipenem during March 2016 2017. Results: In prescribed most frequently for intra-abdominal...