A5040901789- Cardiomyopathy and Myosin Studies
- Cell Adhesion Molecules Research
- Cardiac Structural Anomalies and Repair
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Cardiac tumors and thrombi
- Lipid metabolism and disorders
- Cardiac Valve Diseases and Treatments
- Hematological disorders and diagnostics
- Cancer, Lipids, and Metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Neurogenetic and Muscular Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- Muscle Physiology and Disorders
- Genomics and Rare Diseases
- Cardiovascular Effects of Exercise
- Nuclear Structure and Function
- Cardiovascular Function and Risk Factors
- Pericarditis and Cardiac Tamponade
- Multiple Myeloma Research and Treatments
- Eosinophilic Disorders and Syndromes
- Long-Term Effects of COVID-19
- Chemotherapy-induced cardiotoxicity and mitigation
- ECG Monitoring and Analysis
Northwell Health
2020-2024
North Shore University Hospital
2020-2024
Hofstra University
2021-2024
Lenox Hill Hospital
2024
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2020-2023
Jewish Hospital
2021
Yale University
2019
Brigham and Women's Hospital
2017
Harvard University
2017
Yale New Haven Hospital
2017
Background— With the advent of high throughput sequencing, identification genetic causes cardiovascular disease (CVD) has become an integral part medical diagnosis and management at forefront personalized medicine in this field. The use whole exome sequencing for clinical diagnosis, risk stratification, inherited CVD not been previously evaluated. Methods Results— We analyzed results first 200 adult patients with CVD, who underwent testing Yale Program Cardiovascular Genetics. Genetic was...
F11R is the gene name for an adhesion protein, called F11-receptor, aka JAM-A, which under normal physiological conditions expressed constitutively on surface of platelets and localized within tight junctions endothelial cells (EC). Previous studies interactions between human EC suggested that F11R/JAM-A plays a crucial role in inflammatory thrombosis atherosclerosis. The study reported here obtained in-vivo confirmation this conclusion by investigating protein mRNA patients with aortic...
The F11 Receptor (F11R; aka JAM-A, JAM-1) is a cell adhesion protein present constitutively on the membrane surface of circulating platelets and within tight junctions endothelial cells (ECs). Previous reports demonstrated that exposure ECs to pro-inflammatory cytokines causes insertion F11R molecules into luminal ECs, ensuing with homologous interactions between resultant inflamed ECs. main new finding report first step in this chain events de-novo transcription translation molecules,...
Coronavirus disease 2019 (COVID-19) is a syndrome that has been associated with multiple cardiac complications including myopericarditis. The pathophysiology and treatment for myopericarditis in the setting of COVID-19 infection still under investigation.We present case 60-year-old male admitted dyspnoea due to COVID-19. He developed new ST-segment elevation, elevated enzymes, severe left ventricular dysfunction, high inflammatory markers haemodynamic respiratory collapse from viral illness....
Drug rash with eosinophilia and systemic symptoms (DRESS)–associated myocarditis is a rare but life-threatening adverse drug reaction very high mortality rate no effective therapies. We report case of DRESS-associated complicated by cardiogenic shock successfully treated novel targeted therapy. (Level Difficulty: Advanced.)
Noncompaction cardiomyopathy (NCCM) is characterized by heavy trabeculations, deep intertrabecular recesses, and a thickened myocardium consisting of thin compacted thick non-compacted layer.1 Previously an "unclassified cardiomyopathy", NCCM now recognized as congenital that can occur with other heart diseases or isolated cases. Although rare condition, shares genetic profile hypertrophic dilated cardiomyopathy, leading to strong familial association failure, embolic events, arrhythmias.
The Brugada pattern is associated with a genetic disorder characterized by ST-segment elevation in the right precordial leads on electrocardiogram (EKG) absence of structural heart disease. Patients have an increased risk for ventricular tachyarrhythmia and sudden cardiac death. Loss-of-function mutations SCN5A gene which encodes alpha subunit sodium channel been syndrome (BrS). We report case patient who was found to spontaneous type 1 routine EKG done prior travel. He underwent...
Compound heterozygous familial hypercholesterolemia patients are phenotypically similar to homozygous patients, present with significant elevations of low-density lipoprotein cholesterol, and at risk cardiovascular disease. Although new treatment options emerging, the stepwise approach use different therapies has not been well described. (Level Difficulty: Intermediate.).