A5027631445- Cancer, Hypoxia, and Metabolism
- Neonatal Respiratory Health Research
- Connexins and lens biology
- Cancer-related Molecular Pathways
- Metabolism, Diabetes, and Cancer
- Pulmonary Hypertension Research and Treatments
- Heat shock proteins research
- Fibroblast Growth Factor Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related molecular mechanisms research
- Medical Imaging and Pathology Studies
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Hematological disorders and diagnostics
- Cancer, Lipids, and Metabolism
- Sarcoma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Ovarian cancer diagnosis and treatment
- Ocular Oncology and Treatments
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Adipose Tissue and Metabolism
- Metastasis and carcinoma case studies
Medical University of Białystok
2014-2024
Leiden University
2017
Medical University of Warsaw
2017
Ventana Research Corporation (United States)
2016
Jan Kochanowski University
2015
Wojewódzki Szpital Zespolony im. Jędrzeja Śniadeckiego
2010
Institute of Molecular Pathology and Pathomorphology
2009
University of Arizona
2007
Pathological Society
1998
Abstract Purpose: Recent in vitro studies suggested that the autocrine leptin loop might contribute to breast cancer development by enhancing cell growth and survival. To evaluate whether system could become a target therapy, we examined expression of its receptor (ObR) primary metastatic noncancer mammary epithelium. We also studied leptin/ObR can be induced obesity-related stimuli, such as elevated levels insulin, insulin-like factor-I (IGF-I), estradiol, or hypoxic conditions....
Gap junctions are intercellular channels composed of connexins, which mediate the direct passage small molecules between neighbouring cells. They involved in regulation cell cycle, signalling, and differentiation, probably invasion metastasis. The role connexins metastatic process is controversial, because some studies indicate that connexin expression inversely correlated with capacity. In contrast, others demonstrate may be addition, status breast cancer metastasis has not been widely...
Background: Leptin is an adipocyte-derived neurohormone, high levels of which are found in obese individuals. controls energy expenditure, acting the brain, and regulates different processes peripheral organs. Recent studies have suggested that leptin may be involved cancer development progression. Aims: To analyse expression human colorectal as well mucosa adenomas. Methods: was assessed by immunohistochemistry 166 cancers, 101 samples 41 concentration correlated with selected...
Abstract Colon carcinogenesis is a multistep process where oxygen radicals were found to enhance at all stages: initiation, promotion, and progression. Since insufficient capacity of protective antioxidant system can result in cancer, the aim this study was examine activity enzymes (superoxide dismutase, catalase, glutathione peroxidase, reductase) levels reduced glutathione, vitamin C, E. The lipid peroxidation products also determined by measuring malondialdehyde 4-hydroxynonenal...
An important and ongoing focus of biomedical agricultural avian research is to understand gene function, which for a significant fraction genes remains unknown. A first step determine when where are expressed during development in the adult. Whole mount situ hybridization gives precise spatial temporal resolution expression throughout an embryo, comprehensive analysis centralized repository information would provide valuable tool. The GEISHA project...
Abstract : Recent studies suggested that Ob (Ob) and its receptor (ObR) could be involved in the pathogenesis of various human malignancies, among others endometrial cancer. Moreover, hypoxia, which is associated with solid tumors, might stimulate, through hypoxia‐inducible factor 1α (HIF‐1α), expression ObR. In this article, we analyzed by immunohistochemistry Ob, ObR, HIF‐1α 60 cases cancer tissues as well 25 normal endometria. Additionally, assessed correlations studied proteins...
Periostin, also known as osteoblast-specific factor 2, is a cell-adhesion protein with pleiotropic properties. The serves vital role in the maintenance and development of tooth bone tissue, addition to cardiac healing. Periostin levels are increased several forms cancer, including pancreatic, ovarian, colon, lung, breast, gastric, thyroid, esophageal head neck carcinomas. present review highlights key periostin tumorigenesis, particularly increasing cell survival, invasion, angiogenesis,...
Background: Insulin receptor substrate 1 (IRS-1) transmits signals from the insulin-like growth factor I (IGF-IR) and insulin (IR) has been associated with pathogenesis of cancer. IRS-1 downregulation suggested to play a role in breast cancer progression, but no simultaneous assessments expression primary metastases have performed. Aims: To assess metastatic Methods: was analysed by means immunohistochemistry 109 samples 42 matched tumours. In addition, correlated selected...
Leptin is overexpressed in human breast tumors and produced by cancer cells response to obesity-related stimuli. The leptin promoter polymorphism Lep-2548G/A can be associated with increased secretion adipocytes elevated risk. However, molecular mechanisms underlying the link between have never been addressed. proximal a binding site for transcriptional factor Sp1. Furthermore nucleolin, repressor, bind Sp1 or its consensus site. Consequently, we focused on impact of Sp1- nucleolin-dependent...
<i>Background:</i> Gap junctional intercellular communication (GJIC) is a mechanism for direct cell-to-cell signalling and mediated by gap junctions, which consist of transmembrane proteins called connexins (Cxs). Human colorectal epithelial cells express Cx32 Cx43. <i>Methods:</i> Tissue samples (152 from cancer 75 adenoma) were investigated immunohistochemistry, using the antibody Cx26. Moreover, Cx26 was assessed in normal epithelium colon rectum, adjacent to...
Tumor hypoxia is marked by enhanced expression of hypoxia-inducible factor-α (HIF-1α) and glucose transporter-1 (Glut-1). Hypoxic conditions have also been associated with overexpression angiogenic factors, such as leptin. The aim our study was to analyze the relationships between markers HIF-1α, Glut-1, leptin, leptin receptor (ObR) other breast cancer biomarkers in primary metastatic patients treated or untreated preoperative chemotherapy. different examined immunohistochemistry 116...