A5089357814- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Stroke Rehabilitation and Recovery
- Spinal Cord Injury Research
- Cerebral Palsy and Movement Disorders
- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Traumatic Brain Injury Research
- Muscle activation and electromyography studies
National Institute of Neurological Disorders and Stroke
2024
National Institutes of Health
2024
University of Toronto
2017-2021
University Health Network
2017-2021
Toronto Rehabilitation Institute
2017-2021
In classical cerebellar learning, Purkinje cells (PkCs) associate climbing fiber (CF) error signals with predictive granule (GrCs) that were active just prior (∼150 ms). The cerebellum also contributes to behaviors characterized by longer timescales. To investigate how GrC-CF-PkC circuits might learn seconds-long predictions, we imaged simultaneous GrC-CF activity over days of forelimb operant conditioning for delayed water reward. As mice learned reward timing, numerous GrCs developed...
First Place Award Submission - CA147Category: Clinical ApplicationManagement of obesity after spinal cord injury: a systematic reviewMir Hatef Shojaei1, Mohammad Alavinia1, B. Catharine Craven1,21N...
Abstract Operant conditioning is implemented in brain-machine interfaces (BMI) to induce rapid volitional modulation of single neuron activity control arbitrary mappings with an external actuator. However, intrinsic factors the controller (i.e. brain) or output stage individual neurons) might hinder performance BMIs more complex between hundreds neurons and actuators multiple degrees freedom. Improved be achieved by studying these context BMI control. In this study, we investigated how...
Context/Objective Functional electrical stimulation (FES) is commonly used in rehabilitation to generate electrically-induced muscle contractions. FES has been shown assist the recovery of voluntary motor functions after stroke or spinal cord injury. However, discomfort associated with can motivate patients withdraw their participation from therapy despite its benefits. To address this issue, a functional stimulator, called MyndMove™ (MyndTec Inc., Canada), developed more comfortable...
Context: Firing rates of single cortical neurons can be volitionally modulated through biofeedback (i.e. operant conditioning), and this information transformed to control external devices brain-machine interfaces; BMIs). However, not all respond conditioning in BMI implementation. Establishing criteria that predict neuron utility will assist translation research clinical applications.Findings: Single (n=7) were recorded extracellularly from primary motor cortex a Long-Evans rat. Recordings...
Abstract Objective . Volitional modulation of single cortical neurons holds great potential for the implementation brain–machine interfaces (BMIs) because it can induce a rapid acquisition arbitrary associations between machines and neural activity. It also be used as framework to study limits single-neuron control in BMIs. Approach We tested one-dimensional actuator two BMI tasks which differed only contingency that determined when reward was dispensed. A thresholded activity task, commonly...