A5077513977- Spinal Cord Injury Research
- Cervical and Thoracic Myelopathy
- Stroke Rehabilitation and Recovery
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Nerve Injury and Rehabilitation
- Cerebral Palsy and Movement Disorders
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury Research
- Spinal Dysraphism and Malformations
- Delphi Technique in Research
- Spinal Hematomas and Complications
- Clinical practice guidelines implementation
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- Trauma Management and Diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging and Analysis
- Sports injuries and prevention
- Patient-Provider Communication in Healthcare
- Assistive Technology in Communication and Mobility
- Advanced Neuroimaging Techniques and Applications
Toronto Rehabilitation Institute
2013-2025
University of Toronto
2015-2025
University Health Network
2015-2025
American Physical Therapy Association
2011-2025
KITE Research Institute
2020-2023
Systems, Applications & Products in Data Processing (Canada)
2021
University College Cork
2019-2020
Allen Institute for Brain Science
2020
Krembil Brain Institute
2020
Hôpital Beau-Séjour
2020
Guideline development.The objective of this study is to develop guidelines that outline how best manage (1) patients with mild, moderate, and severe myelopathy (2) nonmyelopathic evidence cord compression or without clinical symptoms radiculopathy.Five systematic reviews the literature were conducted synthesize on disease natural history; risk factors progression; efficacy, effectiveness, safety nonoperative surgical management; impact preoperative duration severity treatment outcomes;...
To develop recommendations on the timing of surgical decompression in patients with traumatic spinal cord injury (SCI) and central syndrome.A systematic review literature was conducted to address key relevant questions. A multidisciplinary guideline development group used this information, along their clinical expertise, for SCI syndrome. Based GRADE, a strong recommendation is worded as "we recommend," whereas weak presented suggest."Conclusions from included (1) isolated studies reported...
The objective of this guideline is to outline the appropriate use methylprednisolone sodium succinate (MPSS) in patients with acute spinal cord injury (SCI).A systematic review literature was conducted address key questions related MPSS SCI. A multidisciplinary Guideline Development Group used information, combination their clinical expertise, develop recommendations for MPSS. Based on GRADE (Grading Recommendation, Assessment, and Evaluation), a strong recommendation worded as "we...
Abstract Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety efficacy ARC EX Therapy improve functions in people with chronic SCI. involves delivery externally applied electrical stimulation over cervical during structured rehabilitation. The primary endpoints were as measured by whether majority participants exhibited significant...
With the advent of new interventions targeted at both acute and chronic spinal cord injury (SCI), it is critical that techniques protocols are developed reliably evaluate changes in upper limb impairment/function. The Graded Redefined Assessment Strength Sensibility Prehension (GRASSP) protocol, which includes five subtests, a quantitative clinical impairment measure designed for use cervical SCI. objectives this study were to: (1) establish inter-rater test-retest reliability, (2) construct...
Cervical spondylotic myelopathy (CSM) is the most common cause of spinal dysfunction in elderly. Operative management beneficial for patients with moderate/severe myelopathy. This study examines potential confounding effects age, sex, duration symptoms, and comorbidities on functional outcomes postoperative complications who underwent cervical decompressive surgery.We included consecutive surgery from December 2005 to October 2007. Functional were assessed using Nurick grading system...
Prospective study.This study aims to determine the psychometric properties of modified Japanese Orthopaedic Association (mJOA) scale.Several outcome measures assess functional impairment and quality life in patients with cervical myelopathy. However, a "gold standard" has not been established. One most widely accepted tools for assessing status is mJOA scale.Two hundred seventy-seven surgical spondylotic myelopathy were enrolled prospective myelopathy-North America study. Functional was...
Object Primary outcome measures for the upper limb in trials concerning human spinal cord injury (SCI) need to distinguish between functional and neurological changes require satisfying psychometric properties clinical application. Methods The Graded Redefined Assessment of Strength, Sensibility Prehension (GRASSP) was developed by International GRASSP Research Design Team as a measure specific limbs individuals with complete incomplete tetraplegia (that is, paralysis or paresis). It can be...
Mixed-method consensus process.Degenerative cervical myelopathy (DCM) is a common and disabling condition that arises when mechanical stress damages the spinal cord as result of degenerative changes in surrounding structures. RECODE-DCM (REsearch Objectives Common Data Elements for Degenerative Cervical Myelopathy) aims to improve efficient use health care resources within field DCM by using multi-stakeholder partnership define research priorities, develop minimum dataset clinical studies,...
Literature Review (Narrative).To introduce the number one research priority for Degenerative Cervical Myelopathy (DCM): Raising Awareness.Raising awareness has been recognized by AO Spine RECODE-DCM as priority. This article reviews evidence that is low, potential drivers, and why this must be addressed. Case studies of success from other diseases are also reviewed, drawing parallels opportunities DCM.DCM may affect many 1 in 50 adults, yet few will receive a diagnosis those do wait years...
Cervical spinal cord injury (SCI) causes extensive impairments for individuals which may include dextrous hand function. Although prior work has focused on the recovery at person-level, factors determining of individual muscles are poorly understood. Here, we investigate muscle-specific after cervical in a retrospective analysis 748 from European Multicenter Study about Spinal Cord Injury (NCT01571531). We show associations between corticospinal tract (CST) sparing and upper extremity SCI,...
<h3>BACKGROUND AND PURPOSE:</h3> T2*-weighted imaging provides sharp contrast between spinal cord GM and WM, allowing their segmentation cross-sectional area measurement. Injured WM demonstrates T2*WI hyperintensity but requires normalization for quantitative use. We introduce WM/GM signal-intensity ratio compare it against area, the DTI metric fractional anisotropy, magnetization transfer in degenerative cervical myelopathy. <h3>MATERIALS METHODS:</h3> Fifty-eight patients with myelopathy...
The objective of this guideline is to outline the role magnetic resonance imaging (MRI) in clinical decision making and outcome prediction patients with traumatic spinal cord injury (SCI).A systematic review literature was conducted address key questions related use MRI SCI. This focused on longitudinal studies that controlled for baseline neurologic status. A multidisciplinary Guideline Development Group (GDG) used information, their expertise, patient input develop recommendations SCI...
Patients with mild degenerative cervical myelopathy (DCM) are often managed non-operatively, and surgery is recommended if neurological progression occurs. However, detection of subjective. Quantitative MRI (qMRI) directly measures spinal cord (SC) tissue changes, detecting axonal injury, demyelination, atrophy. This longitudinal study compared multiparametric qMRI clinical in non-operative DCM patients.26 patients were followed. Clinical data included modified Japanese Orthopedic...
<h3>BACKGROUND AND PURPOSE:</h3> DTI, magnetization transfer, T2*-weighted imaging, and cross-sectional area can quantify aspects of spinal cord microstructure. However, clinical adoption remains elusive due to complex acquisitions, cumbersome analysis, limited reliability, wide ranges normal values. We propose a simple multiparametric protocol with automated analysis report normative data, confounding variables, reliability. <h3>MATERIALS METHODS:</h3> Forty healthy subjects underwent T2WI,...
The objective of this study is to develop guidelines that outline the appropriate type and timing rehabilitation in patients with acute spinal cord injury (SCI).A systematic review literature was conducted address key questions related SCI. A multidisciplinary guideline development group used information, their clinical expertise, recommendations for rehabilitation. Based on GRADE (Grading Recommendation, Assessment, Development Evaluation), a strong recommendation worded as "we recommend,"...
Object While the majority of existing reports focus on complications sustained during chronic stages after traumatic spinal cord injury (SCI), objective in current study was to characterize and quantify acute inpatient complications. In addition, authors sought create a prediction model using clinical variables documented at hospital admission predict complication development. Methods Analyses were based data from Surgical Timing Acute Spinal Cord Injury Study (STASCIS) registry, which...
Object Surgical intervention for appropriately selected patients with cervical spondylotic myelopathy (CSM) has demonstrated favorable outcomes. This study evaluates the cost-effectiveness of this type surgery in terms cost per quality-adjusted life year (QALY) gained. Methods As part a larger prospective multicenter study, direct costs medical treatment 70 undergoing CSM at single institution Canada were retrospectively obtained from hospital expenses database and physician reimbursement...