A5057266440- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Central Venous Catheters and Hemodialysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Diagnosis and Treatment of Venous Diseases
- Case Reports on Hematomas
- Acute Ischemic Stroke Management
- Health and Medical Research Impacts
- Blood Coagulation and Thrombosis Mechanisms
- Pharmaceutical industry and healthcare
- Clinical practice guidelines implementation
- Cardiac Imaging and Diagnostics
- COVID-19 Clinical Research Studies
- Cardiac Arrhythmias and Treatments
- Social Media in Health Education
- Vascular Procedures and Complications
- Hemodynamic Monitoring and Therapy
- Lipoproteins and Cardiovascular Health
- Heparin-Induced Thrombocytopenia and Thrombosis
- Peripheral Artery Disease Management
- Spinal Cord Injury Research
- Healthcare Systems and Technology
- Health Systems, Economic Evaluations, Quality of Life
Thomas Jefferson University Hospital
2016-2025
Thomas Jefferson University
2016-2025
Brigham and Women's Hospital
2024
Harvard University
2024
Jefferson University Hospitals
2011-2023
University of Insubria
2020-2022
American College of Physicians
2009-2021
Technical University of Munich
2019
Sorbonne Paris Cité
2014
Bayer (Netherlands)
2014
Low-molecular-weight heparin has a high bioavailability and prolonged half-life in comparison with conventional unfractionated heparin. Limited data are available for low-molecular-weight as compared the treatment of deep-vein thrombosis.
The clinically appropriate duration of thromboprophylaxis in hospitalized patients with acute medical illnesses is unknown. In this multicenter, randomized, double-blind trial, we evaluated the efficacy and safety oral rivaroxaban administered for an extended period, as compared subcutaneous enoxaparin a standard followed by placebo.
The efficacy and safety of prolonging prophylaxis for venous thromboembolism in medically ill patients beyond hospital discharge remain uncertain. We hypothesized that extended with apixaban would be safe more effective than short-term enoxaparin.In this double-blind, double-dummy, placebo-controlled trial, we randomly assigned acutely who had congestive heart failure or respiratory other medical disorders at least one additional risk factor were hospitalized an expected stay 3 days to...
This study evaluated enoxaparin alone versus initial followed by warfarin in secondary prevention of venous thromboembolic events adults with active malignancy. Cancer patients (n = 122) acute symptomatic were randomly allocated to receive subcutaneous 1.0 mg/kg every 12 hours for 5 days, daily (group 1a) or 1.5 1b) 175 at least days and until a stable international normalized ratio 2 3 was achieved on oral begun day continued 180 2). There no significant differences major minor bleeding...
Venous ultrasound is the standard imaging test for patients suspected of having acute deep venous thrombosis (DVT). There variability and disagreement among authoritative groups regarding necessary components test. Some protocols include scanning entire lower extremity, whereas others recommend scans limited to thigh knee supplemented with serial testing. use gray-scale alone, Doppler interrogation. Point-of-care recommended in some settings, there heterogeneity these as well. Heterogeneity...
To develop recommendations on the timing of surgical decompression in patients with traumatic spinal cord injury (SCI) and central syndrome.A systematic review literature was conducted to address key relevant questions. A multidisciplinary guideline development group used this information, along their clinical expertise, for SCI syndrome. Based GRADE, a strong recommendation is worded as "we recommend," whereas weak presented suggest."Conclusions from included (1) isolated studies reported...
The objective of this guideline is to outline the appropriate use methylprednisolone sodium succinate (MPSS) in patients with acute spinal cord injury (SCI).A systematic review literature was conducted address key questions related MPSS SCI. A multidisciplinary Guideline Development Group used information, combination their clinical expertise, develop recommendations for MPSS. Based on GRADE (Grading Recommendation, Assessment, and Evaluation), a strong recommendation worded as "we...
Background: Low-molecular-weight heparins administered subcutaneously once or twice daily have been reported to be as safe and efficacious intravenous unfractionated heparin in the treatment of acute venous thromboembolic disease. Objective: To determine whether subcutaneous enoxaparin is effective continuously infused symptomatic Design: Randomized, controlled, partially blinded equivalence trial. Setting: 74 hospitals 16 countries. Patients: 900 patients with lower-extremity deep...
Summary Hospitalized patients with acute medical conditions are at significant risk of venous thromboembolism (VTE): approximately 10–30% general may develop deep-vein thrombosis or pulmonary embolism, and the latter is a leading contributor to deaths in hospital. Despite consensus-group recommendations that at-risk should receive thromboprophylaxis, there currently no consensus as which risk, many not appropriate thromboprophylaxis. This paper reviews evidence for VTE associated different...
Patients with acute medical illnesses are at increased risk of venous thromboembolism (VTE), a significant cause morbidity and mortality. Thromboprophylaxis is recommended in these patients but questions remain regarding the optimal duration therapy. The aim this study to determine whether oral rivaroxaban non-inferior standard-duration (approximately 10 days) subcutaneous (s.c.) enoxaparin for prevention VTE acutely ill patients, extended-duration 5 weeks) superior enoxaparin. aged 40 years...