A5069282912- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Spinal Cord Injury Research
- Medical Imaging and Analysis
- Spinal Dysraphism and Malformations
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Scoliosis diagnosis and treatment
- Trauma Management and Diagnosis
- Aortic Disease and Treatment Approaches
- Global Health and Surgery
- Spinal Hematomas and Complications
- Nerve Injury and Rehabilitation
- Optical Coherence Tomography Applications
- Traumatic Brain Injury Research
- Musculoskeletal pain and rehabilitation
- Global Health Workforce Issues
- Photoacoustic and Ultrasonic Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Trauma and Emergency Care Studies
- Cerebrospinal fluid and hydrocephalus
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
University of Calgary
2017-2025
Foothills Medical Centre
2018-2024
University of Toronto
2012-2024
Toronto Western Hospital
2009-2024
University Health Network
2009-2024
Calgary Laboratory Services
2024
Western University
2020
Christie (Canada)
2020
University of British Columbia
2020
Université Laval
2020
Background There is convincing preclinical evidence that early decompression in the setting of spinal cord injury (SCI) improves neurologic outcomes. However, effect surgical patients with acute SCI remains uncertain. Our objective was to evaluate relative effectiveness (<24 hours after injury) versus late (≥24 decompressive surgery traumatic cervical SCI. Methods We performed a multicenter, international, prospective cohort study (Surgical Timing Acute Spinal Cord Injury Study: STASCIS)...
<h3>BACKGROUND AND PURPOSE:</h3> T2*-weighted imaging provides sharp contrast between spinal cord GM and WM, allowing their segmentation cross-sectional area measurement. Injured WM demonstrates T2*WI hyperintensity but requires normalization for quantitative use. We introduce WM/GM signal-intensity ratio compare it against area, the DTI metric fractional anisotropy, magnetization transfer in degenerative cervical myelopathy. <h3>MATERIALS METHODS:</h3> Fifty-eight patients with myelopathy...
Objectives Degenerative cervical myelopathy (DCM) involves extrinsic spinal cord compression causing tissue injury and neurological dysfunction. Asymptomatic (ASCC) is more common, but its significance poorly defined. This study investigates if: (1) ASCC can be automatically diagnosed using shape analysis; (2) multiparametric quantitative MRI detect similar as previously observed in DCM. Design Prospective observational longitudinal cohort study. Setting Single centre, tertiary care research...
<h3>BACKGROUND AND PURPOSE:</h3> Advanced MR imaging techniques are critical to understanding the pathophysiology of conditions involving spinal cord. We provide a novel, quantitative solution map vertebral and cord levels accounting for anatomic variability within human For first time, we report population distribution segmental anatomy cervical that has direct implications interpretation advanced studies most often conducted across groups subjects. <h3>MATERIALS METHODS:</h3> Twenty...
Patients with mild degenerative cervical myelopathy (DCM) are often managed non-operatively, and surgery is recommended if neurological progression occurs. However, detection of subjective. Quantitative MRI (qMRI) directly measures spinal cord (SC) tissue changes, detecting axonal injury, demyelination, atrophy. This longitudinal study compared multiparametric qMRI clinical in non-operative DCM patients.26 patients were followed. Clinical data included modified Japanese Orthopedic...
<h3>BACKGROUND AND PURPOSE:</h3> DTI, magnetization transfer, T2*-weighted imaging, and cross-sectional area can quantify aspects of spinal cord microstructure. However, clinical adoption remains elusive due to complex acquisitions, cumbersome analysis, limited reliability, wide ranges normal values. We propose a simple multiparametric protocol with automated analysis report normative data, confounding variables, reliability. <h3>MATERIALS METHODS:</h3> Forty healthy subjects underwent T2WI,...
The treatment of acute spinal cord injury (SCI) is a multidisciplinary effort that spans from the time through to an care center, and in some cases remainder individual's life. Recovery SCI depends on received at each point along this spectrum time. In order facilitate practice evidence-based medicine best clinical practices, team clinicians researchers systematically reviewed literature set out answer pertinent questions establish recommendations. This article introduces series systematic...
Advances in swept source laser technology continues to increase the imaging speed of swept-source optical coherence tomography (SS-OCT) systems. These fast speeds are ideal for microvascular detection schemes, such as speckle variance (SV), where interframe motion can cause severe artifacts and loss vascular contrast. However, full utilization scan has been hindered by computationally intensive signal processing required SS-OCT SV calculations. Using a commercial graphics unit that optimized...
Introduction While numerous studies have documented evidence for plasticity of the human brain there is little that spinal cord can change after injury. Here, we employ a novel fMRI design where stimulate normal and abnormal sensory dermatomes in persons with traumatic injury perform connectivity analysis to understand how networks process information. Methods Spinal data was collected at 3 Tesla two institutions from 38 individuals using standard SEEP functional MR imaging techniques....
Traumatic spinal cord injury (SCI) has a number of devastating consequences, including high prevalence chronic pain and altered sensitivity. The causes states vary depending on the are difficult to diagnose treat. A better understanding mechanisms after SCI is expected lead diagnostic capabilities improved treatments. We therefore applied functional magnetic resonance imaging (fMRI) brainstem in group participants with previous traumatic characterize changes processing as result their...
Intraoperative image-guided surgical navigation for craniospinal procedures has significantly improved accuracy by providing an avenue the surgeon to visualize underlying internal structures corresponding exposed surface anatomy. Despite obvious benefits of navigation, adoption remains relatively low due long setup and registration times, steep learning curves, workflow disruptions. We introduce experimental system utilizing optical topographical imaging (OTI) acquire 3D anatomy cavity,...