A5062276852- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Cardiac Arrest and Resuscitation
- Spine and Intervertebral Disc Pathology
- Brain Metastases and Treatment
- Spinal Dysraphism and Malformations
- Advanced MRI Techniques and Applications
- Neurological Disorders and Treatments
- Traumatic Brain Injury Research
- Optical Imaging and Spectroscopy Techniques
- Cervical and Thoracic Myelopathy
- Acute Ischemic Stroke Management
- Medical Imaging and Analysis
- Scoliosis diagnosis and treatment
- Spinal Cord Injury Research
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Heterotopic Ossification and Related Conditions
- Hemoglobin structure and function
- Neonatal and fetal brain pathology
- Cerebrospinal fluid and hydrocephalus
- Musculoskeletal pain and rehabilitation
- Machine Learning in Healthcare
Marshall University
2018-2024
University of Toronto
2002-2018
Sunnybrook Health Science Centre
1998-2016
Spinal Injuries Center
2016
Health Sciences Centre
2012-2016
St. Michael's Hospital
2002
Object Cerebral autoregulation may be altered after traumatic brain injury (TBI). Recent evidence suggests that patients' autoregulatory status following severe TBI influence cerebral perfusion pressure management. The authors evaluated the utility of incorporating a recently upgraded parenchymal thermal diffusion probe for measurement blood flow (CBF) in neurointensive care unit assessing and vasoreactivity at bedside. Methods 20 patients with admitted to San Francisco General Hospital who...
Intraoperative image-guided surgical navigation for craniospinal procedures has significantly improved accuracy by providing an avenue the surgeon to visualize underlying internal structures corresponding exposed surface anatomy. Despite obvious benefits of navigation, adoption remains relatively low due long setup and registration times, steep learning curves, workflow disruptions. We introduce experimental system utilizing optical topographical imaging (OTI) acquire 3D anatomy cavity,...
This study describes a new method used to evaluate axonal physiological dysfunction following fluid percussion induced traumatic brain injury (TBI) that may facilitate the of mechanisms and novel therapeutic strategies posttraumatic diffuse (DAI). Stimulated compound action potentials (CAP) were recorded extracellularly in corpus callosum superfused slices at 3 h, 1, 3, 7 days central demonstrated temporal pattern functional deterioration. The maximal CAP amplitude (CAPA) covaried with...
OBJECTIVE The optimal site for placement of tissue oxygen probes following traumatic brain injury (TBI) remains unresolved. authors used a previously described swine model focal TBI and studied tension (P bt O 2 ) at the sites contusion, proximal distal to in contralateral hemisphere determine effect probe location on P assess effects physiological interventions these different sites. METHODS A controlled cortical impact device was generate lesion right frontal lobe 12 anesthetized swine....
Our purpose was to report efficacy of hypofractionated cavity stereotactic radiotherapy (HCSRT) in patients with and without prior whole brain (WBRT). 32 surgical cavities 30 (20 patients/21 had no WBRT 10 patients/11 WBRT) were treated image-guided linac radiotherapy. 7 the "resistant" local disease given surgery, post-operative a re-operation, followed by salvage HCSRT. The clinical target volume post-surgical cavity, 2-mm margin applied as planning volume. median total dose Gy (range:...
The comparative effectiveness of decompression plus lumbar facet arthroplasty versus instrumented spinal fusion in patients with stenosis and grade-I degenerative spondylolisthesis is unknown.
Purpose To validate ferumoxytol-based quantitative blood oxygenation level-dependent (BOLD) MRI for mapping of human infiltrative astrocytomas by using intraoperative measurement tissue oxygen tension and histologic staining. Materials Methods Fifteen patients with were recruited into this prospective multicenter study between July 2014 December 2016. Prior to treatment, participants underwent preoperative BOLD ferumoxytol generate saturation (StO2) maps. Two intratumoral sites identified,...
A 54-year-old female presented with a two year history of progressive headaches and upper neck pain. The were worse coughing bending. Neurological examination was unremarkable including normal cranial nerve examination. There no papilloedema. computed tomogram (CT) demonstrated midline, posterior fossa, partly fatty, solid mass (Figure 1). Magnetic resonance imaging (MRI) mixed arising from the fourth ventricle extending downward below foramen magnum to C1 level 2). portions enhancement. In...
INTRODUCTION: The optimal site for placement of tissue oxygen probes following traumatic brain injury (TBI) remains unresolved. We studied tension (PbtO2) at the sites contusion, proximal and distal to in contralateral hemisphere determine effect probe location on PbtO2 assess effects physiological interventions these different sites. METHODS: A controlled cortical impact (CCI) device was used generate a focal lesion right frontal lobe 12 anesthetized swine. measured using Licox placed...