A5054255550- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological disorders and treatments
- Spinal Cord Injury Research
- Parkinson's Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Spinal Dysraphism and Malformations
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- EEG and Brain-Computer Interfaces
- Spinal Fractures and Fixation Techniques
- Neurosurgical Procedures and Complications
- CAR-T cell therapy research
- Neuroscience and Neuropharmacology Research
- Nerve Injury and Rehabilitation
- Epilepsy research and treatment
- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Neural dynamics and brain function
- Vascular Malformations Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
Houston Methodist
2014-2023
Methodist Hospital
2012-2023
St. Michael's Hospital
2020-2021
Duke University
2021
Toronto Western Hospital
2020-2021
University of Toronto
2021
Thomas Jefferson University Hospital
2021
St Michaels Hospital
2020
University of Saskatchewan
2020
Oxford University Press (United Kingdom)
2020
The Galveston Orientation and Amnesia Test (GOAT) was developed to evaluate cognition serially during the subacute stage of recovery from closed head injury. This practical scale measures orientation person, place, time, memory for events preceding following distribution test scores in 50 patients who had recovered a mild injury used define range variation performance analyze effects demographic factors. In validity study 52 head-injured patients, duration impaired GOAT strongly related...
Objective: The purpose of this study was to compare the effects two acute-care management strategies on frequency jugular venous desaturation and refractory intracranial hypertension long-term neurologic outcome in patients with severe head injury. Design: Randomized clinical trial. Setting: Level I trauma hospital. Patients: One hundred eighty-nine adults admitted coma because Interventions: Patients were assigned either cerebral blood flow (CBF)-targeted or pressure (ICP)-targeted...
<h3>Importance</h3> Glioblastoma is an incurable tumor, and the therapeutic options for patients are limited. <h3>Objective</h3> To determine whether systemic administration of HER2-specific chimeric antigen receptor (CAR)–modified virus-specific T cells (VSTs) safe these have antiglioblastoma activity. <h3>Design, Setting, Participants</h3> In this open-label phase 1 dose-escalation study conducted at Baylor College Medicine, Houston Methodist Hospital, Texas Children’s with progressive...
A multicenter double-blind randomized trial was conducted to examine the efficacy of a high dose methylprednisolone (1,000-mg bolus and daily thereafter for ten days) compared with standard (100-mg in 330 patients acute spinal cord injury. No difference neurological recovery motor function or pinprick light touch sensation observed between two treatment groups six weeks months after The lack effect independent severity initial lesion time from injury starting treatment. Although not...
The therapeutic efficacy of adenovirus-mediated herpes simplex virus thymidine kinase (HSV-tk) gene transduction rat C6 glioma cells followed by ganciclovir (GCV) administration was studied in tumors generated the brains nude mice. were efficiently transduced vitro a replicative-defective recombinant adenovirus carrying HSV-tk (ADV/RSV-tk) that rendered them sensitive to GCV dose-dependent manner. Tumors stereotaxic intracerebral injection 1 x 10(4) After 8 days tumor growth, 3 10(8)...
✓ This paper describes the pilot phase of National Traumatic Coma Data Bank, a cooperative effort six clinical head-injury centers in United States. were collected on 581 hospitalized patients with severe non-penetrating traumatic head injury. Severe injury was defined basis Glasgow Scale (GCS) score 8 or less following nonsurgical resuscitation deterioration to GCS within 48 hours after A common data collection protocol, definitions, and instruments developed put into use by all commencing...
Early experience with continuous monitoring of jugular venous oxygen saturation (SjvO2) suggested that this technology might allow early identification global cerebral ischaemia in patients severe head injury. The purpose the present study was to examine relationship between episodes desaturation and neurological outcome. One hundred sixteen severely head-injured had SjvO2 during days 1-5 after Episodes (SjvO2 < 50% for more than 10 minutes) were prospectively identified, incidence...
✓ The continuous measurement of jugular venous oxygen saturation (SjvO 2 ) with a fiberoptic catheter is evaluated as method detecting cerebral ischemia after head injury. Forty-five patients admitted to the hospital in coma severe injury had and simultaneous monitoring SjvO , intracranial pressure, arterial saturation, end-tidal CO . Cerebral blood flow, metabolic rates lactate, gas levels, hemoglobin concentration were measured every 8 hours for 1 11 days. Whenever dropped less than 50%,...
✓ The hypothesis that cerebral arteriovenous difference of oxygen content (AVDO 2 ) can be used to predict blood flow (CBF) was tested in patients who were comatose due head injury, subarachnoid hemorrhage, or cerebrovascular disease. In 51 CBF measured daily for 3 5 days, and 49 every 8 hours 10 days after injury. the latter group patients, when a low (≤ 0.2 ml/gm/min) an increased level lactate production (CMRL) −0.06 µ mol/gm/min) encountered, therapy instituted increase CBF, measurements...
Abstract Purpose: Glioblastoma multiforme (GBM) is the most aggressive human primary brain tumor and currently incurable. Immunotherapies have potential to target GBM stem cells, which are resistant conventional therapies. Human epidermal growth factor receptor 2 (HER2) a validated immunotherapy target, we determined if HER2-specific T cells can be generated from patients that will autologous HER2-positive GBMs their CD133-positive cell compartment. Experimental Design: 10 consecutive were...
✓ Long-term recovery from severe closed head injury was investigated in predominantly young adults whose Glasgow Coma score 8 or less at the time of admission. Of 27 patients studied (median follow-up interval 1 year), 10 attained a good recovery, 12 were moderately disabled, and five severely disabled. In contrast to previous studies suggesting that intellectual ability after eventually recovers normal level, our findings showed residual memory storage retrieval, linguistic deficit,...
✓ A multi-center double-blind randomized clinical trial was conducted by the National Acute Spinal Cord Injury Study Group to examine efficacy of high-dose methylprednisolone (1000-mg bolus and 1000 mg daily thereafter for 10 days) compared with that a standard dose (100-mg 100 days). No significant difference observed in neurological recovery motor function, pinprick response, or touch sensation 1 year after injury between two treatment groups, adjustment other potentially confounding...
Plasma norepinephrine (NE) and dopamine beta-hydroxylase (DBH) levels were measured during the first 7 days after head injury in 48 patients. Blood pressure, pulse, temperature, Glasgow coma score (GCS) recorded at time of sampling for each patient, relationships these to NE DBH examined. In patients with multiple trauma, usually elevated, regardless GCS. alone, however, was proportional Alert a brief loss consciousness (GCS, 14) had normal levels. Those as high times normal. temperature...
Outcomes for patients with glioblastoma (GBM) remain poor despite aggressive multimodal therapy. Immunotherapy genetically modified T cells expressing chimeric antigen receptors (CARs) targeting interleukin (IL)-13Rα2, epidermal growth factor receptor variant III (EGFRvIII), or human 2 (HER2) has shown promise the treatment of gliomas in preclinical models and a clinical study (IL-13Rα2). However, IL-13Rα2 EGFRvIII is associated development loss variants, there are safety concerns HER2....
✓ The traditional practice of elevating the head in order to lower intracranial pressure (ICP) head-injured patients has been challenged recent years. Some investigators argue that with hypertension should be placed a horizontal position, rationale being this will increase cerebral perfusion (CPP) and thereby improve blood flow (CBF). However, ICP is generally significantly higher when patient position. This study was undertaken clarify issue optimal position care patients. effect 0° 30°...
Between December 1996 and September 1998, 13 patients with advanced recurrent malignant brain tumors (9 glioblastoma multiforme, 1 gliosarcoma, 3 anaplastic astrocytoma) were treated a single intratumoral injection of 2 × 109, 1010, 1011, or 1012 vector particles (VP) replication-defective adenoviral bearing the herpes simplex virus thymidine kinase gene driven by Rous sarcoma promoter (Adv.RSVtk), followed ganciclovir (GCV) treatment. The VP to infectious unit ratio was 20:1. Our primary...