A5046244920- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- Forest Insect Ecology and Management
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- DNA and Nucleic Acid Chemistry
- Forest Ecology and Biodiversity Studies
- Chemical synthesis and alkaloids
- Carbohydrate Chemistry and Synthesis
- Marine Sponges and Natural Products
- Fluorine in Organic Chemistry
- Chemical Reaction Mechanisms
- Organophosphorus compounds synthesis
- Click Chemistry and Applications
- Insect and Pesticide Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bioactive Compounds and Antitumor Agents
- Traditional and Medicinal Uses of Annonaceae
University of Nottingham
2012-2024
US Forest Service
2008-2024
NOAA Oceanic and Atmospheric Research
2024
National Oceanic and Atmospheric Administration
2024
Park University
2016-2020
University of Limerick
2015-2016
Indiana University Kokomo
2014
University of Michigan
1988-2013
Michigan United
2013
Pacific Southwest Research Station
2009-2011
Early experience with continuous monitoring of jugular venous oxygen saturation (SjvO2) suggested that this technology might allow early identification global cerebral ischaemia in patients severe head injury. The purpose the present study was to examine relationship between episodes desaturation and neurological outcome. One hundred sixteen severely head-injured had SjvO2 during days 1-5 after Episodes (SjvO2 < 50% for more than 10 minutes) were prospectively identified, incidence...
UVB-induced lesions in mammalian cellular DNA can, through the process of mutagenesis, lead to carcinogenesis. However, eukaryotic cells have evolved complex mechanisms genomic surveillance and damage repair counteract effects UVB radiation. We show that following damage, there is an overall inhibition protein synthesis translational reprogramming. This reprogramming allows selective DDR proteins, such as ERCC1, ERCC5, DDB1, XPA, XPD, OGG1 relies on upstream ORFs 5′ untranslated region these...
AbstractThe proto-oncogenes c-, L-, and N-myc can all be translated by the alternative method of internal ribosome entry whereby is recruited to a complex structural element (an segment [IRES]). Ribosome recruitment dependent upon presence IRES-trans-acting factors (ITAFs) that act as RNA chaperones allow mRNA attain correct conformation for interaction 40S subunit. One major challenges researchers in this area determine whether there are groups ITAFs regulate IRES-mediated translation...
Abstract Copper‐ or rhodium‐catalyzed reactions of diazocarbonyl compounds with β‐hydroxyketones give highly substituted tetrahydrofurans excellent diastereoselectivity. Under mild conditions, the single‐step process starts as a carbene OH insertion reaction, but is diverted by an intramolecular aldol reaction.
The copper-catalysed oxidative coupling of amines and H-phosphonates to produce phosphoramidates has been achieved using CuI as the catalyst O2 (present in air) sole oxidant.
Abstract A highly stereoselective route to functionalized pyrrolidines by the metal‐catalyzed diverted N−H insertion of a range diazocarbonyl compounds with β‐aminoketone derivatives is described. number catalysts (rhodium(II) carboxylate dimers, copper(I) triflate, and an iron(III) porphyrin) are shown promote process under mild conditions give wide substituted proline derivatives. The reaction starts as metallocarbene but intermolecular aldol reaction.
The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to include antivirals treat acute infections, in addition the judicious use effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass vaccination, modest number or development any disease bears testament challenges antiviral development. We recently showed that non-cytotoxic levels thapsigargin (TG), an inhibitor sarcoplasmic/endoplasmic reticulum (ER) Ca2+ ATPase pump, induces a potent...
A method is described for the detection of certain nucleotide modifications adjacent to 5' 7-methyl guanosine cap mRNAs from individual genes. The quantitatively measures relative abundance 2'-O-methyl and N6,2'-O-dimethyladenosine, two most common modifications. In order identify quantitatify amounts a novel synthesis modified adenosine phosphoramidites was developed. This one step product can directly be used production N6,2'-O-dimethyladenosine containing RNA oligonucleotides. nature...
Microreactors: A highly efficient continuous-flow process has been developed for the synthesis of diazoesters from arylsulfonylhydrazones by means in-flow Bamford–Stevens reactions. Furthermore, a range α-alkoxy and α-amino acid derivatives have prepared in excellent yields through rhodium(II)-mediated OH NH insertions, without need to isolate or handle potentially hazardous diazo species (see scheme).
Myotonic dystrophy (DM) is a multi-system neuromuscular disorder for which there no treatment. We have developed medium throughput phenotypic assay, based on the identification of nuclear foci in DM patient cell lines using situ hybridization and high-content imaging to screen potentially useful therapeutic compounds. A series further assays molecular features also been employed. Two compounds that reduce and/or remove identified, Ro 31-8220 chromomycin A3. PKC inhibitor, previously shown...
A multigram synthesis of the C29-C51 subunit altohyrtin C (spongistatin 2) has been accomplished. Union this intermediate with C1-C28 fragment and further elaboration furnished natural product. Completion began aldol coupling boron enolate derived from methyl ketone 8 aldehyde 9. Acid-catalyzed deprotection/cyclization resulting diastereomeric mixture addition products was conducted in a single operation to afford E-ring C. The diastereomer obtained through cyclization unwanted product...
An alkylidene carbene 1,5-CH insertion has been used as a key step in an enantioselective total syntheses of omuralide, its C7-epimer, and (+)-lactacystin. additional noteworthy feature the synthesis is use novel oxidative deprotection procedure, utilizing DMDO, for conversion late-stage benzylidene acetal into primary alcohol secondary benzoate ester.
Treating readily available α-diazo-β-ketoesters with HBF(4) results in nucleophilic fluorination by the usually inert and stable tetrafluoroborate anion. The resulting α-fluoro-β-ketoesters are highly versatile synthetic intermediates, for example preparation of fluoro-heterocycles, as illustrated direct formation fluoro-pyrimidines, -pyrazoles -coumarins a single step.
Emerald ash borer (Agrilus planipennis) is an invasive pest that has killed millions of trees (Fraxinus spp.) in the USA since its first detection 2002. Although current methods for trapping emerald borers (e.g., sticky traps and trap trees) visual ground aerial surveys are generally effective, they inefficient precisely locating assessing declining dead large or hard-to-access areas. This study was conducted to develop evaluate a new tool safe, efficient, precise assessment decline death...
A method for the palladium-catalyzed synthesis of alkynylphosphonates from 1,1-dibromo-1-alkenes has been developed. In general, best catalyst system this transformation was found to be Pd(OAc)2, dppf, H-phosphonate, propylene oxide, DMF, 80 °C. The reaction appears tolerant a range functional groups in both 1,1-dibromo-1-alkene and H-phosphonate coupling partners. backbone-modified thymidine dimer is used illustrate application methodology complex target molecules.
Rhodium(II) catalysts and PhIO in benzene convert homoallylic carbamates into the corresponding aziridines at room temperature.
We have developed an in-flow process for the synthesis of β-keto esters via BF3·OEt2-catalyzed formal C−H insertion ethyl diazoacetate into aldehydes. The were then condensed with a range amidines to give variety 2,6-substituted pyrimidin-4-ols.
Abstract Highly reactive metal carbenes, generated from simple ketones via diazo compounds, including diazo‐amides and ‐phosphonates, using a recyclable reagent in‐flow, are transient but versatile electrophiles for heteroatom alkylation reactions epoxide formation. The method produces no organic waste, with the only by‐products being water, KI nitrogen, without attendant hazards of isolation intermediate compounds.
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Method for Constructing the C18−C28 Dispiroacetal Moiety of Altohyrtin AChristopher J. Hayes and Clayton H. HeathcockView Author Information Department Chemistry, University California, Berkeley, California 94720 Cite this: Org. Chem. 1997, 62, 9, 2678–2679Publication Date (Web):May 2, 1997Publication History Received30 January 1997Published online2 May inissue 1...
The synthesis of nemorosone, a polyprenylated acylphloroglucinol isolated from Clusia rosea, was achieved by means bridgehead substitution process, involving initial iodination and subsequent lithium-iodine exchange followed acylation. difficulties in the are discussed, probable explanation proposed, based on molecular modelling.