A5006514890- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Mitochondrial Function and Pathology
- Pharmacological Effects and Toxicity Studies
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Education, Psychology, and Social Research
- Diet and metabolism studies
- Hearing Loss and Rehabilitation
- Photoreceptor and optogenetics research
- Neurological Disorders and Treatments
- Ion channel regulation and function
- Anesthesia and Neurotoxicity Research
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience of respiration and sleep
- Axon Guidance and Neuronal Signaling
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Orthopedic Surgery and Rehabilitation
- Neurological and metabolic disorders
- Electron Spin Resonance Studies
Charles University
2011-2025
Czech Academy of Sciences, Institute of Physiology
2007-2025
Czech Academy of Sciences
2007-2025
Czech Academy of Sciences, Institute of Experimental Medicine
2003
Bridge University
2001
University of Verona
1993
Status epilepticus (StE) in immature rats causes long-term functional impairment. Whether this is associated with structural alterations remains controversial. The present study was designed to test the hypothesis that StE at an early age results neuronal loss. induced lithium–pilocarpine 12-d-old rats, and presence of damage investigated brain from 12 hr up 1 week later using silver Fluoro-Jade B staining techniques. Analysis sections indicated consistent central lateral segments...
Abstract It remains under dispute whether status epilepticus (SE) in the perinatal period or early childhood underlying neuropathology is cause of functional impairment later life. The present study examined SE induced by LiCl–pilocarpine normal immature brain (at age 12 25 days; P12 P25) causes cognitive decline and epileptogenesis, data were compared to those rats undergoing as adults. Rats group had impaired memory (repeated exposure open‐field paradigm) emotional behaviour (lower...
The neocortex contains two neuron types, excitatory (glutamatergic) pyramidal cells and inhibitory nonpyramidal (GABAergic) cells. GABAergic, interneurons are morphologically distinct from account for 20–25 % of all neocortical neurons. Recent studies discovered that besides morphological features, molecularly physiologically heterogenous differ significantly in arrangement terminations their axonal endings. In interneurons, GABA is also co-localized with calcium-binding proteins...
This study investigated the striatopallidal complex's involvement in status epilepticus (SE) caused by morphological neurodegenerative changes a post-natal immature developing brain lithium-pilocarpine male Wistar albino rat model of mesial temporal lobe epilepsy. One hundred experimental pups were grouped age as follows: 12, 15, 18, 21, and 25 days. SE was induced lithium-pilocarpine. Brain sections microscopically examined Fluoro-Jade B fluorescence stain at intervals 4, 24, 48 h 1 week...
The distribution and morphology of neuronal degeneration were observed analyzed in each sector the zona incerta a lithium‑pilocarpine (LiCl) Wistar rat model status epilepticus 12, 15, 18, 21, 25‑day‑old rats survival intervals 4, 8, 24, 48 hours. Status was induced via intraperitoneal (IP) injection LiCl (3 mmol/kg) 24 hours before an pilocarpine (40 mg/kg, IP). Motor seizures suppressed by paraldehyde (0.3‑0.6 ml/kg, IP) two after onset. Animals anesthetized using urethane perfused with...
The neural substrate subserving magnetoreception and magnetic orientation in mammals is largely unknown. Previous experiments have demonstrated that the processing of sensory information takes place superior colliculus. Here, effects field conditions on neuronal activity rodent navigation circuit were assessed by quantifying c-Fos expression. Ansell's mole-rats ( Fukomys anselli ), a mammalian model to study mechanisms compass orientation, subjected natural, periodically changing, shielded...
<b><i>Background:</i></b> Surgical therapy of intractable mesial temporal lobe epilepsy (MTLE) is an effective and well-established treatment. <b><i>Objectives:</i></b> We compared two different surgical approaches, standard microsurgical anterior resection (ATL) stereotactic radiofrequency amygdalohippocampectomy (SAHE) for MTLE, with respect to the extent or destruction, clinical outcomes, complications. <b><i>Material...
Epilepsy is a neurologic disorder, particularly frequent in infants and children where it can lead to serious consequences later life. Oxidative stress mitochondrial dysfunction are implicated the pathogenesis of many neurological disorders including epilepsy adults. However, their role immature epileptic brain unclear since there have been two contrary opinions: oxidative age-dependent does not occur during status epilepticus (SE) and, on other hand, evidence specific model SE. To solve...
This is the first neuropathology report of a male patient (born 1960–died 1975) with an extremely rare, atypical variant CLN2 that has been diagnosed only in five families so far. The clinical history started during his preschool years relatively mild motor and psychological difficulties, but normal intellect vision. Since age six there were progressive cerebellar extrapyramidal symptomatology, amaurosis, mental deterioration. Epileptic seizures absent. child died aged 15 extreme cachexy....