A5040067937- Hemoglobinopathies and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Iron Metabolism and Disorders
- Alcohol Consumption and Health Effects
- Blood disorders and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Food composition and properties
- Inflammatory mediators and NSAID effects
- Neonatal Health and Biochemistry
- Hemophilia Treatment and Research
- Cutaneous lymphoproliferative disorders research
- Inflammatory Biomarkers in Disease Prognosis
- Parvovirus B19 Infection Studies
- Chronic Lymphocytic Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Pregnancy and preeclampsia studies
- Mycobacterium research and diagnosis
- Forensic Toxicology and Drug Analysis
- Genetic Associations and Epidemiology
- Peripheral Artery Disease Management
Fox Chase Cancer Center
2019-2024
Asociación por los Derechos Civiles
2023
Baylor College of Medicine
2014-2021
Dan L Duncan Comprehensive Cancer Center
2021
St. Luke's Hospital
2021
Universidad Nacional de Cuyo
2020
Cellular Therapeutics (United Kingdom)
2020
Texas Children's Hospital
2019
Vanderbilt University
2013-2016
HI Iberia (Spain)
2015
Meta-analyses have demonstrated that low-dose aspirin reduces the risk of developing adenocarcinoma metastasis, and when colon cancer is detected during treatment, there a remarkable 83% reduction in metastasis. As platelets participate metastatic process, antiplatelet action likely contributes to its antimetastatic effect. Cycloxooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) also we addressed hypothesis inhibits PGE2 biosynthesis. We show systemic biosynthesis by 45% healthy...
The thromboxane synthase converts prostaglandin H2 to A2 and malondialdehyde (MDA) in approximately equimolar amounts. A reactive dicarbonyl, MDA forms covalent adducts of amino groups, including the ε-amine lysine, but importance this reaction platelets was unknown. Utilizing a novel LC/MS/MS method for analysis one adducts, dilysyl-MDA cross-link, we demonstrated that cross-links human are formed following platelet activation via cyclooxygenase (COX)-1/thromboxane pathway. Salicylamine...
Pancreatic cancer (PC) carries a high risk of venous thromboembolism (VTE). Several assessment models (RAMs) predict benefit thromboprophylaxis in solid tumors; however, none are verified metastatic pancreatic (mPC).A retrospective mPC cohort treated at an academic center from 2010 to 2016 was investigated for VTE incidence (VTEmets). Multivariable regression analysis used assess multiple factors. Overall survival (OS) compared between groups with and without VTE. Survival analyzed using...
Topic: 16. Myeloproliferative neoplasms - Clinical Background: The majority of MF pts treated with approved Janus kinase inhibitors fail to achieve spleen volume response (SVR [³35%]) and continue have persistent splenomegaly MF-related symptoms. Nvtm is a potent, selective, orally available mouse double minute 2 inhibitor (MDM2i) that induces apoptosis in TP53 wild-type (TP53WT) CD34+ myeloblasts by overcoming dysregulated MDM2 (Lu 2017). Single agent nvtm demonstrated clinically meaningful...
Liquid biopsy is a valuable tool in advanced and metastatic cancers for detection of genomic alterations tumors that facilitate personalized targeted therapy approaches. Analyzing circulating tumor DNA (ctDNA) using next-generation sequencing (NGS) provides an opportunity to detect changes during capture inter- intra-heterogeneity genomically divergent cancer cell evolution. Herein, we present patient with castration-resistant prostate cancer, progression soft tissues, bone, regional lymph...
Down syndrome (DS) or trisomy 21 is the most prevalent chromosomopathy. Interesting associations have been documented between DS and various hematopoietic non-hematopoietic malignancies. Transient myeloproliferative disorder (TMD) a clonal proliferation of megakaryoblasts, typically occurring in newborns with DS. It believed that TMD occurs presence GATA-1 mutation together 21. The resolved majority patients during first six months life, however, 30% can develop acute leukemia...
Abstract Patients with chronic lymphocytic leukemia (CLL), a B‐cell malignancy characterized by impaired humoral and cellular immunity, are at increased risk of developing cutaneous squamous cell carcinoma (cSCC). Human papilloma virus (HPV) is the most common sexually transmitted infection worldwide it has been associated various malignancies, including cSCC. Impaired cell‐mediated immunity considered primary factor in HPV‐induced We examined cSCC lesions from CLL patients consensus review...
Copyright © 2020 Harris. This is an open-access article distributed under the terms of Creative Commons At - tribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided original work properly cited.
The present report describes our clinical findings regarding the use of high dose intravenous insulin in cancer patients, as a means to deplete blood compartment glucose molecules. purpose this intervention is create favorable physiological state for competitive inhibition several rate-limiting enzymes within cells, with structural analogues that behave antimetabolites. Regardless their histological origin, virtually all solid tumors reported on date (February 2020) are found be hypercaptant...
Abstract Background We report a patient with Essential Thrombocythemia (ET), subsequently diagnosed concurrent myeloid and lymphoid leukemia. Generally, the molecular mechanisms underlying leukemic transformation of Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are poorly understood. Risk to acute myelogenous leukemia (AML) is low; both AML lymphoblastic (ALL) extremely low. Genetic defects, including allele burden, order mutation acquisition, clonal heterogeneity epigenetic...
In vivo platelet activation is associated with several pathologic entities, including acute coronary syndrome, essential thrombocythemia, anti-phospholipid antibody diabetes and metabolic syndrome. The need for more robust biomarkers which to assess in human diseases well recognized. Our lab has developed two novel assays study rate of turnover. During activation, malondialdehyde (MDA) produced by the thromboxane synthase amounts equimolar A2 also non-enzymatically lipid peroxidation...