A5101463567- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Cancer survivorship and care
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- Phytase and its Applications
- Mast cells and histamine
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- Sleep and related disorders
- Pancreatic and Hepatic Oncology Research
- Multiple Myeloma Research and Treatments
- Cancer-related cognitive impairment studies
- Head and Neck Cancer Studies
Mackay Medical College
2014-2025
Mackay Memorial Hospital
2014-2025
Mackay Junior College of Medicine, Nursing and Management
2024
Clinical Research Management
2021
Tamkang University
2018
The University of Texas MD Anderson Cancer Center
1989-2011
Taipei Medical University Hospital
2005
National Science and Technology Council
2005
Background/Objectives: Breast cancer remains the leading malignancy affecting women worldwide, with significant mortality rates. This study aimed to evaluate prognostic significance of FOXM1 expression specifically in hormone receptor-positive, HER2-negative (HR+HER2-) breast patients high KPNA2 expression, and identify potential FOXM1-targeted therapeutic strategies for this patient subgroup. Methods: We analyzed RNA sequencing microarray data from three independent cohorts: Mackay Memorial...
The epidermal growth factor (EGF) receptor (EGFR) overexpressed in many cancers, including lung and head neck is involved cancer cell progression survival. PD-L1, increases tumor cells to evade inhibit CD8+ T cells, a clinical immunotherapeutic target. This study investigated the molecular mechanism of EGF on regulating PD-L1 EGFR-positive cancers determined potential agents reduce expression. RNA sequencing (RNAseq) bioinformatics analysis were performed determine driver genes that regulate...
Background Epidemiological studies have indicated that impaired glucose metabolism may increase the risk of squamous cell carcinoma head and neck (SCCHN). AMP-activated protein kinase (AMPK) regulates lipid via phosphorylation subsequent inactivation its downstream target acetyl-CoA carboxylase (ACC).Thus, we analyzed expression pAMPK phosphorylated (pACC), as well their impact on survival patients with resected SCCHN. Methods One hundred eighteen surgically SCCHN were enrolled....
Oxaliplatin is a third-generation platinum analog that used mainly to treat advanced colorectal cancer. The reported incidence of hypersensitivity reactions oxaliplatin, especially after multiple cycles therapy, less than 1%. We report patient with metastatic colon cancer who developed reaction oxaliplatin during the sixth cycle combination chemotherapy high-dose 5-fluorouracil and leucovorin. same occurred again re-exposure 2 weeks later even prophylactic administration steroids H1...
Objectives: To evaluate the effects of Reishimmune-S, a fungal immunomodulatory peptide, on quality life (QoL) and natural killer (NK) cell subpopulations in patients receiving adjuvant endocrine therapy (ET) for breast cancer (BC). Methods: Patients who received ET stage I-III hormone receptor-positive BC without active infection were enrolled this prospective pilot study. Reishimmune-S was administered sublingually daily 6 months. QoL scores, circulating immune levels, including...
The clinical benefit of adding platinum to adjuvant chemotherapy for patients with triple-negative breast cancer (TNBC) has not been well investigated, although it was associated an improved response rate in neoadjuvant setting. We retrospectively analyzed the time tumor progression (TTP) and overall survival (OS) resected stage I-III TNBC who were treated or without cisplatin-containing (CisCT noCisCT) during 2004 2010. Of 129 patients, 25 received CisCT. In univariate analysis, mean TTP...
Abstract Rationale: The diagnosis of anaplastic lymphoma kinase ( ALK )-negative inflammatory myofibroblastic tumors (IMT) remains challenging because their morphological resemblance with spindle cell sarcoma characteristics. Patient concerns: A 69-year-old female patient presented loco-regional recurrent IMT several times within 8 years after primary treatment and neck lymph node metastasis 3.5 last recurrence. Diagnosis: primary, recurrence, lesions were diagnosed as ALK-negative IMTs...
Transcatheter arterial embolization (TAE) is an important palliative treatment for patients with hepatocellular carcinoma (HCC) who are poor candidates surgery or percutaneous ablative therapy. It generally takes 4 wk after lipiodol-TAE to properly assess lipiodol retention on computed tomography (CT). HBV DNA integrated into the genome of HCC cells, and circulating plasma may serve as a marker cell damage. We assessed changes in TAE HBV-related correlated levels pattern accumulation...
e17503 Background: Accumulating evidence has shown that overexpression of casein kinase 2 (CK2) in patients with squamous cell carcinoma head and neck (SCCHN) correlates worsened survival. Strong expression phosphorylated acetyl CoA carboxylase (pACC) was found to be an independent prognostic marker for node-positive SCCHN. Computational analysis showed ACC a potential substrate CK2, CK2 inhibition can suppress phosphorylation non-cancer cells. CX-4945, also known as silmitasertib, is orally...
][6] KIT D816V mutation can be detected in .90% of SM patients. 7Interestingly, multilineage involvement and multimutations other genes such as SRSF2, ASXL1, RUNX1 are frequently advSM. 8[12] Recently, the multikinase inhibitor midostaurin was approved for treatment advSM on basis its clinical activity 116 adults with 13Currently, both primary acquired resistance to challenges advSM.The complexity dynamics mutational profiles midostaurin-treated have been studied by using serial...
Accumulating evidence shows that high expression of casein kinase 2 (CK2) and phosphorylated acetyl CoA carboxylase (pACC) in patients with squamous cell carcinoma the head neck (SCCHN) correlates decreased survival rates. Computational analysis has shown ACC is a potential substrate for CK2, its inhibition can suppress phosphorylation vitro. CX-4945, also known as silmitasertib, an orally administered, highly specific, ATP-competitive inhibitor CK2 under clinical investigation treatment...
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Kaposi’s sarcoma is a human herpes virus 8 associated-angioproliferative disorder, which commonly associated with immunocompromised conditions such as those arise in renal transplant recipients, or acquired immune-deficiency syndrome (AIDS) cases. It less well described, however, patients solid tumors undergoing adjuvant chemotherapy after surgery. We report the case of an HIV-negative heterosexual Taiwanese man who developed second primary 5 months start for stage III colon cancer....
Abstract Squamous cell carcinoma of the head and neck (HNSCC) is sixth most common cancer worldwide. One primary modalities used to treat HNSCC external radiotherapy, however many tumors are resistant this treatment. Several studies have noted increased expression IL-6 receptor in a variety tumors. Furthermore, inhibition using monoclonal antibody, tocilizumab, as monotherapy has been shown decrease tumor growth pre-clinical models. However effect signaling on radiosensitivity not well...
Abstract Squamous cell carcinoma of head and neck (SCCHN) is the tenth most common cancer in world. Unfortunately, survival patients with SCCHN has not improved last 40 years. Therefore new targets for therapy are needed, to this end we studying signaling pathways activated by IL-6 which have found stimulates migration soft agar growth SCCHN. Our data show that increases TWIST expression a transcription-independent mechanism many lines. Further investigation reveals can be phosphorylated...