A5030218475- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Proteins in Food Systems
- Hydrogels: synthesis, properties, applications
- Drug Solubulity and Delivery Systems
- Antimicrobial Peptides and Activities
- Antimicrobial agents and applications
- Computational Drug Discovery Methods
- Biochemical Analysis and Sensing Techniques
- Cancer Research and Treatment
- Alcohol Consumption and Health Effects
- Advanced biosensing and bioanalysis techniques
- melanin and skin pigmentation
- Microencapsulation and Drying Processes
- Dendrimers and Hyperbranched Polymers
- Nanocluster Synthesis and Applications
- Electrospun Nanofibers in Biomedical Applications
- Research on Leishmaniasis Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemotherapy-induced organ toxicity mitigation
- Food Chemistry and Fat Analysis
- Polydiacetylene-based materials and applications
ARC Centre of Excellence in Advanced Molecular Imaging
2023-2024
UNSW Sydney
2024
China Pharmaceutical University
2017-2022
State Council of the People's Republic of China
2020
To develop safer and more effective antimicrobial polymers, this study investigates how the structure (linear vs. cyclic) hydrophilic/hydrophobic balance of terpolymers affect their toxicity selectivity against bacteria.
Cationic polymers have gained significant attention as potent antimicrobial agents due to the emergence of antibiotic resistance. These can interact with negatively charged bacterial cell membranes, leading disruption membrane structure and ultimately causing death bacteria. While quaternary ammonium is most utilized cationic group in polymers, there an increasing interest exploring other groups, such phosphonium sulfonium, for applications. However, limited research has been conducted on...
Natural polymers have been extensively utilized in the past decades due to their outstanding features. Among these natural excipients, protein‐based superb features owing high drug binding capacity and biodegradability. Whey protein is a versatile vehicle for delivery systems. It has shown be nontoxic, biocompatible, biodegradable. Therefore, it considered as an ideal biomaterial design of advanced Protein‐based cargo acts synthetic counterpart innovative The current review mainly focused on...
Understanding the intricate relationship between polymer architecture and biological activity is critical for advancing development of antibacterial polymers. In this study, we systematically investigated properties hemocompatibility 27 different synthetic polymers prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. The activities these were probed against two gram-negative bacteria, namely Pseudomonas aeruginosa PAO1 Escherichia coli K12. Furthermore,...
Aptamers are small, functional single-stranded DNA or RNA oligonucleotides that bind to their targets with high affinity and specificity. Experimentally, aptamers selected by the systematic evolution of ligands exponential enrichment (SELEX) method. Here, we have used rational drug designing bioinformatics methods design aptamers, which involves three different steps. First, finding a probable aptamer-binding site, second, recognition structural parts generating virtual library sequences,...
The modern process of new drug discovery and development is an exciting, yet a challenging, endeavor. Although it can result in significant financial income meet the medical needs patients, ultimately may failure. To achieve fast successful product process, natural products which are evolutionarily optimized as drug-like molecules have gained great attention better potential sources chemical entities. Historically, plant species containing berberine used various traditional phytotherapy....
Hydrogels are cross‐linked three‐dimensional polymeric networks that play a vital role in solving the pharmacological and clinical limitations of existing systems due to their unique physical properties such as affinity for biological fluids, tunable porous nature, high water content, ease preparation, flexibility, biocompatibility. Hydrogel also mimics living natural tissue, which opens several opportunities its use biomedical areas. Injectable hydrogel allows temporal control exceptional...
Tyrosinase plays an important role in melanin biosynthesis and protects skin against ultraviolet radiations. Functional deficiency of tyrosinase results serious dermatological diseases. also participates neuromelanin formation the human brain, which leads to neurodegeneration resulting Parkinson's disease. In fruits vegetables, a critical senescence, causing undesired browning that faster deterioration shorter shelf lines. The only commercially available is mushroom it shows highest homology...
Nimodipine (NMD) is a calcium channel blocker that used in the treatment of cerebrovascular disorders, such as stroke indicated for biological rhythm and neurological disorders. According to biopharmaceutical classification, NMD categorized class ΙΙ drug, meaning it has poor solubility profile. The objective this experiment prepare multicomponent systems enhance solubility, dissolution, bioavailability NMD. Inclusion complex solvent evaporation techniques have been exploited overcome...