Mojtaba Falahati

ORCID: 0000-0003-3964-7437
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About
Contact & Profiles
Research Areas
  • Nanoparticle-Based Drug Delivery
  • SARS-CoV-2 and COVID-19 Research
  • Nanoparticles: synthesis and applications
  • RNA Interference and Gene Delivery
  • Nanoplatforms for cancer theranostics
  • Circular RNAs in diseases
  • Advanced biosensing and bioanalysis techniques
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Photonic and Optical Devices
  • Semiconductor Lasers and Optical Devices
  • MicroRNA in disease regulation
  • Microtubule and mitosis dynamics
  • Laser-Ablation Synthesis of Nanoparticles
  • COVID-19 Clinical Research Studies
  • Graphene and Nanomaterials Applications
  • Nanocluster Synthesis and Applications
  • Advanced Nanomaterials in Catalysis
  • Viral gastroenteritis research and epidemiology
  • Computational Drug Discovery Methods
  • Epigenetics and DNA Methylation
  • Influenza Virus Research Studies
  • Radiative Heat Transfer Studies
  • Molecular Communication and Nanonetworks
  • Carbohydrate Chemistry and Synthesis
  • Cancer Research and Treatment

Erasmus MC Cancer Institute
2024

Ansys (United States)
2024

Islamic Azad University Medical Branch of Tehran
2019-2023

Erasmus University Rotterdam
2021-2022

Erasmus MC
2021-2022

Smith-Kettlewell Eye Research Institute
2021

Harvard University
2021

Massachusetts Eye and Ear Infirmary
2021

Washington State University
2019

Islamic Azad University Pharmaceutical Sciences Branch
2018

Implementations of nanoparticles have been receiving great interest in medicine and technology due to their unique characteristics. However, toxic impacts on the biological system are not well explored.This study aims investigate influence fabricated nano graphene oxide (NGO) sheets secondary quaternary structural alterations human hemoglobin (Hb) cytotoxicity against lymphocyte cells.Different spectroscopic methods, such as extrinsic synchronous fluorescence spectroscopy far circular...

10.2147/ijn.s174048 article EN cc-by-nc International Journal of Nanomedicine 2018-10-01

Functional genomics is an emerging field focused on elucidating the functions of genes or proteins, which can help solve challenges related to reliable cancer therapy. One main currently faced by therapy variations in number mutations patients, leading drug resistance and relapses. Drug intrinsic acquired resistance, generally associated with most There are advanced tools that identify mutant tissues causing (CDR). Such include but not limited DNA RNA sequencing as well assynthetic lethality...

10.1016/j.heliyon.2023.e22095 article EN cc-by-nc-nd Heliyon 2023-11-15

Chitosan–heparin nanoparticles (CS-HP NPs) can be used as potential nano-based platforms for development of drug delivery carriers. In this article, doxorubicin (Dox)@CS-HP NPs were synthesized and their physicochemical characteristics assessed. Afterwards, anticancer effects against gastric cancer (AGS) cells assessed by MTT, LDH, ROS, qPCR assays, whereas peripheral blood mononuclear (PBMCs) control normal cells. It was observed that blank CS-HP [email protected] showed average...

10.1016/j.arabjc.2021.103266 article EN cc-by-nc-nd Arabian Journal of Chemistry 2021-06-18

The interaction of nanoparticles with biological systems can provide useful information about their therapeutic applications. aluminum (Al2O3 NPs) were synthesized by laser ablation technique and well-characterized different methods. Fluorescence spectroscopy, circular dichroism (CD) molecular docking studies employed to evaluate the effect Al2O3 NPs on protein structure. Growth inhibitory apoptotic effects against K562 cancer cells lymphocyte assessed using...

10.1016/j.arabjc.2020.102923 article EN cc-by Arabian Journal of Chemistry 2020-12-04

The aim of this study was to investigate the mechanism interaction between quercetin-3-O-sophoroside and different SARS-CoV-2's proteins which can bring some useful details about control variants coronavirus including recent case, Delta. chemical structure first optimized. Docking studies were performed by CoV disease-2019 (COVID-19) Server. Afterwards, molecular dynamic done using High Throughput Molecular Dynamics (HTMD) tool. results showed a remarkable stability based on calculated...

10.1016/j.arabjc.2021.103353 article EN cc-by-nc-nd Arabian Journal of Chemistry 2021-07-28

Tumor treating fields (TTFields) are among clinically active anticancer modalities that utilize low‐intensity, intermediate frequency (IF), and alternating electric (AEFs) to selectively disrupt mitosis in cancerous cells. Application of TTFields the range 100–900 kHz cancer therapy its effect on normal cells have attracted a great deal interest recent years. affect solid tumors by introducing increased chromatid aberrations reduce capacity repair DNA damage chromosome segregation, resulting...

10.1016/j.arabjc.2021.103386 article EN cc-by-nc-nd Arabian Journal of Chemistry 2021-08-16
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