Treatment of large wounds is technically demanding and several attempts have been taken to improve wound healing. Aloe vera has shown some beneficial roles on healing but its mechanism various stages the process not clear. This study was designed investigate effect topical application A. cutaneous in rats.A rectangular 2 × 2-cm created dorsum back rats. The animals were randomly divided into 3 groups control (n = 20), low-dose high-dose 20) vera. treated daily with saline, (25 mg/mL), (50...

Introduction Bone tissue usually heals spontaneously, but in complicated conditions such as pathological fractures or those situations leading to large bone defects, the healing process fails. Therefore, it is still a challenge for orthopaedic surgeons treat and reconstruct delayed unions non-unions. A variety of therapeutic modalities have been developed enhance response fill defects. Different types glycosaminogl ycans, growth factors, stem cells, natural grafts (auto-, allo- xenografts)...

Surgical reconstruction of tendon injuries is challenging. Classic reconstructive techniques and transplantation have some significant limitations tissue engineering a newer option. Despite development in technologies, the role healing still unclear. There are many tissueengineered products that commercially available market, but most them not passed animal clinical studies, behaviour host immune response to these types has been investigated. Researchers also focused on vitro investigations...

This study was designed to evaluate the effects of sodium-hyaluronate (NaH) combined with glucosamine HCl-chondroitin sulfate (GlcN-CS) on post-surgical repair tendon rupture day 84 post injury. Twenty white New Zealand female rabbits were divided randomly into two equal groups injured treated and untreated. After tenotomy surgical repair, using modified Kessler technique running pattern, legs casted for 14 days. NaH injected subcutaneously over lesion days 3, 7, 10 followed by daily oral...

To investigate the effect of topical application silymarin on full-thickness cutaneous wounds in rats.A defect (2×2cm) was induced back 85 male and female Wister rats. The animals were randomly divided into four groups (n=20 each group), treated with 1ml basal cream (placebo low-dose (6mg/ml/rat) high-dose (12mg/ml/rat) silymarin, untreated (control). Five rats remained uninjured to serve as comparisons for biomechanical analysis. Wounds evaluated 10, 20 30 days after injury, through...

Healing of large tendon defects is challenging. We studied the role collagen implant with or without polydioxanone (PDS) sheath on healing a Achilles defect model, in rabbits. Sixty rabbits were divided into three groups. A 2 cm gap was created left all In control lesions, no used. The other two groups reconstructed by and collagen-PDS implants respectively. animals clinically examined at weekly intervals their lesions observed ultrasonography. Blood samples obtained from assessed for...

Abstract Bovine platelet gel ( BPG ) is an accessible and cost‐effective source of growth factors which may have a value in tendon regenerative medicine. We produced collagen implant CI as proper, covered it with polydioxanone PDS sheath to simulate paratenon finally embedded the active factor within bioimplant test whether would be able accelerate enhance regeneration repair. After vitro characterization bioactive grafts, grafts were implanted rabbit large defect model. Untreated tendons...