A5031722282- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Cardiovascular Issues in Pregnancy
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiovascular and Diving-Related Complications
- Cardiac tumors and thrombi
- Cardiac and Coronary Surgery Techniques
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Iron Metabolism and Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Takotsubo Cardiomyopathy and Associated Phenomena
- Trypanosoma species research and implications
- Viral Infections and Immunology Research
Emory University
2021-2025
Emory Clinic
2024-2025
Emory University Hospital
2024
University of Maryland, Baltimore
2018-2021
Assiut University
2021
University of Maryland Medical Center
2019-2021
Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct alternative non-foam cell antiinflammatory macrophage phenotype that was previously considered atheroprotective. Here, we reveal an unexpected but important pathogenic role for these macrophages in atherosclerosis. Using human atherosclerotic samples, cultured cells, and mouse model advanced atherosclerosis, investigated intraplaque hemorrhage on function with respect angiogenesis, vascular permeability,...
Statins have anti-inflammatory and immunomodulatory effects that may reduce the severity of coronavirus disease 2019 (COVID-19), in which organ dysfunction is mediated by severe inflammation. Large studies with diverse populations evaluating statin use outcomes COVID-19 are lacking.We used data from 10,541 patients hospitalized through September 2020 at 104 US hospitals enrolled American Heart Association's Cardiovascular Disease (CVD) Registry to evaluate associations between outcomes....
Vascular calcification is routinely encountered in percutaneous coronary intervention (PCI) and severe a known predictor of in-stent restenosis stent thrombosis. However, the histopathologic mechanisms behind such events have not been systematically described.
Right ventricular (RV) failure after left assist device (LVAD) implantation continues to be a morbid complication. In this study, we hypothesized that less invasive approach would preserve RV function relative conventional sternotomy (CS) approach.All patients (2013-2017) who underwent LVAD were reviewed. Patients stratified by surgical approach: thoracotomy with hemi-sternotomy (LTHS) and CS. The primary outcome was severe failure.Eighty-three (LTHS: 37, CS: 46) identified. median...
The intestinal microbiome has emerged as a potential contributor to the severity of sickle cell disease (SCD). We sought determine whether SCD mice exhibit barrier dysfunction, inflammation, and dysbiosis. Using Townes humanized mouse model, we found 3-fold increase in permeability assessed via FITC-dextran (4 kDa) assay SS (SCD) compared AA (wild type) (
Objective Despite improvement in outcomes after left ventricular assist device (LVAD) implantation over the past 2 decades, high-risk recipients continue to have a prohibitive rate of morbidity and mortality. We hypothesized that less invasive approach LVAD would be associated with improved survival compared conventional this cohort. Methods All consecutive (2013 2017) underwent centrifugal were retrospectively reviewed. Patients classified as if INTERMACS 1 or required temporary...
Significant residual mitral regurgitation (MR) after left ventricular assist device (LVAD) implantation has been associated with increased morbidity and mortality. The effect of cannula position on improvement preexisting MR yet to be evaluated. Consecutive patients who underwent centrifugal LVAD >mild preoperative without concomitant repair were reviewed. Left was determined by the angle between actual ideal inflow computed tomography. magnitudes angles (anterior lateral angle) added...
The functional and molecular imaging characteristics of ischemic ventricular tachycardia (VT) substrate are incompletely understood. Our objective was to compare regional <sup>18</sup>F-FDG PET tracer uptake with detailed electroanatomic maps (EAMs) in a more extensive series postinfarction VT patients define the metabolic properties successful ablation sites. <b>Methods:</b> Three-dimensional (3D) left reconstructions were created from perfusion-normalized images consecutive undergoing...
BackgroundBoth percutaneous coronary interventions (PCIs) and robotic-assisted artery bypass (CAB) offer viable options for left anterior descending (LAD) chronic total occlusion (CTO) revascularization. Our study aims to compare long-term clinical outcomes associated with these 2 strategies.MethodsIn this retrospective study, we analyzed data from 273 patients diagnosed LAD CTO who underwent either PCI (n = 129) or CAB 144) at a single institution. Long-term follow-up was available 96 125...
Background: The current guideline-recommended intervention for left main (LM) disease is coronary artery bypass grafting (CABG). Hybrid revascularization (HCR) combines robotic and percutaneous (PCI) offers a less invasive approach patients with LM multivessel disease. We aim to compare clinical outcomes at 30 days, 6 months 1 year between HCR CABG in Methods: retrospectively screened 761 who underwent 2019 2023 single institution. A total of 118 either (n=59) or were included after...
Coronary artery calcium (CAC) is the measure of subclinical coronary atherosclerosis most strongly associated with atherosclerotic cardiovascular disease (ASCVD) risk. However, CAC rarely reported in inpatient setting to guide chest pain management. We present a case very high 64-year-old woman hypertension, type 2 diabetes, and hyperlipidemia presenting dyspnea. Initial electrocardiogram (ECG) demonstrated normal conduction heart rate 76 beats/min, but new T-wave inversions V1–V4...
Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased risk of cardiovascular morbidity and mortality. Impaired left ventricular (LV) global longitudinal strain (GLS) can be a sign subclinical cardiac dysfunction even in patients otherwise preserved ejection fraction (EF). Transmitral early filling velocity to diastolic rate (E/SRe) is novel measure LV pressure, which often affected disease. A total 110 ADPKD not on dialysis were included this prospective study....