A5038480001- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Animal Disease Management and Epidemiology
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Respiratory viral infections research
- Animal Virus Infections Studies
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Animal Genetics and Reproduction
- Heparin-Induced Thrombocytopenia and Thrombosis
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- CRISPR and Genetic Engineering
- interferon and immune responses
- RNA Interference and Gene Delivery
- COVID-19 Clinical Research Studies
Sanofi (Mexico)
2016
University of California, Irvine
2000
Universidad Autónoma de Nuevo León
1995
Asia is considered an important source of influenza A virus (IAV) pandemics, owing to large, diverse viral reservoirs in poultry and swine. However, the zoonotic origins 2009 A/H1N1 pandemic (pdmH1N1) remain unclear, due conflicting evidence from swine humans. There strong that first human outbreak pdmH1N1 occurred Mexico early 2009. no related viruses have been detected or any part Americas, date most closely ancestor were identified Asian Here, we use 58 new whole-genome sequences IAVs...
There is still a need for safe, efficient, and low-cost coronavirus disease 2019 (COVID-19) vaccines that can stop transmission of severe acute respiratory syndrome 2 (SARS-CoV-2). Here we evaluated vaccine candidate based on live recombinant Newcastle virus (NDV) expresses stable version the spike protein in infected cells as well surface viral particle (AVX/COVID-12-HEXAPRO, also known NDV-HXP-S). This be grown embryonated eggs at low cost, similar to influenza vaccines, it administered...
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed in record time and show excellent efficacy effectiveness disease 2019 (COVID-19). However, currently approved vaccines cannot meet the global demand. In addition, none of used is administered intranasally to potentially induce mucosal immunity. Here, we tested safety immunogenicity a second-generation SARS-CoV-2 vaccine that includes stabilized spike antigen can be intranasally. The based on live...
Abstract There is still a need for safe, efficient and low-cost coronavirus disease 2019 (COVID-19) vaccines that can stop transmission of severe acute respiratory syndrome 2 (SARS-CoV-2). Here we evaluated vaccine candidate based on live recombinant Newcastle virus (NDV) expresses stable version the spike protein in infected cells as well surface viral particle (AVX/COVID-12-HEXAPRO, also known NDV-HXP-S). This be grown embryonated eggs at low cost similar to influenza it administered...
The protective dose of a live recombinant LaSota Newcastle disease virus (NDV)-avian influenza H5 vaccine (rNDV-LS/AI-H5) was determined in broiler chickens with high levels maternal antibodies against NDV and avian (AIV). At hatch the geometric mean titers (GMT) chickens' were 2(5.1) 2(10.3) for AIV, respectively. time vaccination GMT 2(3.1) 2(7.9) AIV. vaccinated one drop (0.03 ml) eye at 10 days age as is typical under field conditions. test received 10(4.8), 10(5.8), 10(6.8), or 10(7.8)...
Abstract Background The global inequity in coronavirus disease 2019 (COVID-19) vaccine distribution, primarily affecting low- and middle-income countries (LMICs), highlights the urgent need for innovative cost-effective technologies to address availability disparities. This is crucial achieving sustaining widespread immunity protecting vulnerable populations during future booster campaigns. Methods To this need, we conducted a phase II clinical trial evaluating safety immunogenicity of...
Abstract Background The urgent need for safe, effective, and economical coronavirus disease 2019 (COVID-19) vaccines, especially booster campaigns targeting vulnerable populations, prompted the development of AVX/COVID-12 vaccine candidate. AVX/COVD-12 is based in a Newcastle virus La Sota (NDV-LaSota) recombinant viral vector. This expresses stabilized version spike protein severe acute respiratory syndrome 2 (SARS-CoV-2), specifically ancestral Wuhan strain. study aimed to assess its...
Specific-pathogen-free chickens immunized at 14 days of age with either an inactivated recombinant Newcastle disease virus–LaSota/avian influenza H5 (K-rNDV-LS/AI-H5) vaccine or a killed disease/avian whole-virus (K-ND/AI) were protected from when challenged A/chicken/Queretaro/14588-19/95 (H5N2), high pathogenicity avian virus (HPAIV) strain isolated in Mexico 1995, Mexican velogenic viscerotropic (VVNDV) 21 postvaccination. All nonvaccinated HPAIV VVNDV succumbed to disease, while those...