Abstract Chronic rhinitis is the most common ENT disease. Over past decade, there has been an increased incidence of chronic rhinitis. In all forms rhinitis, a decrease in protective properties nasal mucous membrane, which can be accompanied by activation bacterial microflora. Dysbiosis microbiota contributes to development inflammation, immune cells with reactions, lipid peroxidation processes and changes activity antioxidant defense factors cavity blood. There evidence that different...

Relevance. Chronic rhinosinusitis is the most common inflammatory disease of ENT organs in world.Objective. Study cytokine regulation patients with chronic depending on phenotypeMaterial and methods. A total 61 were selected, which 13 had allergic (CRS), 10 polypous rhinosinusitis, 24 infectious 14 hyperplastic rhinosinusitis. The control group consisted 30 practically healthy blood donors matched by gender age. Cytokine levels determined serum individuals ELISA method Thermo Scientific...

Gastric cancer is a global health problem. The pathogenesis of this disease remains unclear. This study included 198 H. pylori (+) men aged 45 to 60 years old. Group A 63 practically healthy men, group B with severe atrophic body gastritis, C 37 epithelial gastric stages I–II according TNM, and D 54 III–IV the TNM scale. content malondialdehyde (MDA), diene conjugates (DCs), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), peroxidase (GPO) was detected using an...

В последние годы отмечается рост больных с метаболическим синдромом, что является актуальной проблемой медицины. Выраженность клинических проявлений метаболического синдрома оказывает влияние на качество жизни пациентов, при этом снижаются показатели физического и психического здоровья. Ожирение приводит к тревожным расстройствам, неврозоподобным состояниям депрессиям, способствует ухудшению основного заболевания.
 Имеющиеся клинические экспериментальные данные убедительно показывают...

Метаболический синдром (МС) является серьезной медицинской, социальной и экономической проблемой. Своевременная диагностика МС, терапия (лечение ожирения, нарушений углеводного обмена, артериальной гипертензии, дислипидемии) профилактика (контроль массы тела, определение индекса физическая активность рациональное питание) будут способствовать эффективному снижению риска сердечно-сосудистых осложнений, связанных с атеросклерозом.

Experimental preparations based on a DNA vaccine encoding the ESAT-6 antigen of Mycobacterium tuberculosis have been obtained (KpONE6) and studied for immunogenic effects in murine model. The core preparation contains recombinant plasmid pONE6 encapsulated within spermidine-polyglucin conjugate, thereby protecting from degradation. KpONE6 induces proliferative T-cell immune response mice upon intramuscular immunization.

Currently, non-alcoholic fatty liver disease is one of the most common chronic diseases. In recent years, this condition has been considered as a hepatic manifestation metabolic syndrome, which associated with overweight and impaired glucose fat metabolism. Despite obvious role lifestyle in development disease, it increasingly being suggested that disorders metabolism fats carbohydrates have genetic basis, determines tendency to develop NAFLD. Mutant polymorphisms HSD17B13 , GCKR HFE CP...

To study the processes of lipid peroxidation and activity antioxidant defense enzymes depending on chemiluminescent neutrophilic granulocytes in patients with gastric cancer associated H. pylori infection, stage.A total 39 stage I-II 30 III-IV were examined. A was carried out parameters system protection plasma determined using spectrophotometric method. Statistical data processing performed Statistica 7.0 software package (StatSoft, St Tulsa, OK, USA).In regardless stage, proportion normal...

Mechanical jaundice (MJ) of malignant genesis is a clinical syndrome caused by obturation bile ducts due to tumor growth. It characterized specific pigmentation skin, mucous membranes and sclerae increased accumulation bilirubin in blood serum other fluids tissues the organism. Various immune disorders are detected patients with mechanical jaundice. Immune reactivity affected toxic, infectious, or factors. In connection these findings, aim our study was measure levels some pro-inflammatory...

Rationale. The article examines the assessment of quality life, psychological state (anxiety-depressive disorders, neurosis-like states) in patients with metabolic syndrome. prevalence syndrome different countries is 25-30% and varies depending on criteria used. severity clinical manifestations affects life patients, while indicators physical mental health decrease. problem suffering from overweight obesity relevant socially significant. Obesity leads to anxiety-depressive states, which...

Aim. To study changes in the indices of prooxidant and antioxidant systems plasma men with atrophic gastritis gastric cancer. Materials methods. The included 60 healthy men, 42 patients 50 nicardipine cancer stage II according to TNM. All underwent serological diagnosis diffuse (definition pepsinogens gastrin-17) Helicobacter pylori infection. "atrophic gastritis" was verified by morphological examination biopsy specimens obtained during fibroesophagogastroduodenoscopy. Diagnosis carried out...

Background: Infectious complications — the leading cause of mortality in patients with multiple myeloma (MM), their appearance is regarded as an adverse prognostic factor course disease.Objective: The aim our study was to evaluate clinical and immunological features infectious G- immunochemical MM find most informative indicators forecasting. Methods: A randomized controlled trial made. All were divided into 3 groups for comparison: Group 1 (n =47) patients, G-immunochemical variant...

According to the World Health Organization, more than 2.1 billion adults are overweight, while about 600 million obese. Arterial hypertension is a component of complete metabolic syndrome, its severity, possibility effective correction depends on severity disorders in patient.
 The aim our study was age, sex and parameters affecting course AH MS order optimize therapy for patients with MS.
 Material methods. included 316 syndrome aged 35 65 years. average age 51.8 ± 6.4 In total,...

Aim: To study the predominant serum responses (antibodies IgG, IgA, IgE) against H. pylori in relation to indicators of system “lipid peroxidation−antioxidant system” various pathogenetic variants chronic gastritis (CG). Materials and Methods: Sixty patients with CG, 33 atrophic (CAG) 31 allergic (CALG) were examined. The values lipid peroxidation antioxidant protection plasma determined using a spectrophotometric method. Statistical data processing was carried out Statistica 7.0 software...

Non-alcoholic fatty liver disease currently affects more than 30% of the population. Recent studies highlight role genetic polymorphisms in genes associated with fat catabolism and anabolism manifestation this condition its progression. The work analyzes foreign publications on molecular biochemical aspects these polymorphisms, as well works studying their effect state markers pathology over past 10 years. Thus, PNPLA3, MBOAT7, TM6SF2, affecting functionality proteins they express, lead to a...

Triple-negative breast cancer (TNBC) is definied by the lack of expression estrogen receptor, progesterone receptor and HER2. TNBC has been characterized aggressive course, early development metastases, poor overall survival rates compared to other subtypes cancer. Molecular genetic studies have allowed discover different molecular (i. e., basal-like, claudin-low), demonstrated presence «immune-activated» with better disease outcome. In addition, further features characteristic TNBC,...

Mechanical jaundice (MJ) is a severe pathological condition, caused by obstruction of the bile ducts, requiring immediate surgical intervention. Etiologically, MJ can be benign (60-80% cases,) or malignant origin. progression depends on underlying pathology, and, moreover, bilirubin levels. Focal inflammation in affected area represents significant mechanism progression. Neutrophilic granulocytes, are primarily involved into immune response, i.e., pathogen elimination. Hence, MJ progression...

About 50-85% of patients suffer from stump and phantom pain after amputations. These chronic conditions are often debilitating result in disability, sleep psychosocial disorders, impairment day-work the substantial decline quality life. In some pharmaceutical therapy may fail to bring satisfactory relief or follows severe adverse events. Operations such as rhizotomy, cordotomy revision unsuccessful treating post-amputation pain. The solitary case reports about using minimally invasive...

Бактерия Helicobacter pylori приводит к запуску цитокинового каскада. В нашем исследовании мы изучили показатели некоторых цитокинов (ИЛ-2, ИЛ-4, ИЛ-8, TNF-α, интерферона-γ) у больных хроническим гастритом и атрофическим на фоне инфекции. Во всех группах хроническими гастритами атрофическими с H. инфекцией регистрировалось увеличение провоспалительных интерферон-γ, ИЛ-8) противовоспалительных (ИЛ-4) цитокинов.

At present, the level of Helicobacter pylori infection is determined by geographic area, gender and age examined individuals, can reach up to 95% total population. Environmental adaptation H. exhibited in its ability adhere gastric mucosal epithelium modulated expression own virulent factors. Current concepts implicate that survive inside epithelial cells, evading host immune response. Cytokines are produced cells act regulate major stages. A cytokine cascade launched after triggers...

Клиническая иммунология