A5076860087- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Nanoparticle-Based Drug Delivery
- Research on Leishmaniasis Studies
- Lymphoma Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Dielectric properties of ceramics
- Trypanosoma species research and implications
- Bone Tissue Engineering Materials
- Colorectal Cancer Treatments and Studies
- Circadian rhythm and melatonin
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Crystallization and Solubility Studies
- Neuroblastoma Research and Treatments
- Metal complexes synthesis and properties
- Dental Implant Techniques and Outcomes
- Metabolism, Diabetes, and Cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Dendrimers and Hyperbranched Polymers
- Toxin Mechanisms and Immunotoxins
- Advanced Nanomaterials in Catalysis
- Neonatal Health and Biochemistry
University of Burdwan
2018-2024
Indian Institute of Technology Bombay
2024
Following invasion of the host cell, pore-forming toxins secreted by pathogens compromise vacuole integrity and expose microbe to diverse intracellular defence mechanisms. However, quantitative correlation between toxin expression levels consequent pore dynamics, fostering life pathogens, remains largely unexplored. In this study, using Streptococcus pneumoniae its pneumolysin (Ply) as a model system, we explored various facets host-pathogen interactions in cytosol. Using time-lapse...
T-cell exhaustion plays a pivotal role in the resistance of microsatellite-stable colorectal cancer (CRC) to immunotherapy. Identifying and targeting exhaustion-activating mechanisms is promising strategy augment effects Here, we found that thymidine phosphorylase (TYMP) decisive inducing systemic abrogating efficacy dendritic cell (DC) therapy CRC model. Targeting TYMP with tipiracil hydrochloride (TPI) induces immunological death (ICD). The combined TPI imiquimod-activated DCs turn CT26...
A triple stimuli-responsive drug delivery platform involving doxorubicin, 5-fluoro-2-deoxy uridine and folic acid was fabricated on mesoporous silica nanoparticles for targeting against a highly aggressive murine lymphoma called Dalton's lymphoma. Fabrication of the unique construct by amalgamating active passive mechanisms offers novel hyper-chimeric system. The enables efficient precise precious cargo to tumor sites. Active directs doxorubicin in close proximities cells, causing killing...
Galunisertib (LY2157299) is a selective ATP-mimetic inhibitor of TGF-β receptor-I activation, currently under clinical trial in variety cancers. We have tested the combined effects galunisertib- and interleukin-15-activated dendritic cells an aggressive highly metastatic murine lymphoma. Based on tumor-draining lymph node architecture, its histology, combination therapy results better prognosis, including disappearance disease-exacerbating regulatory T cells. Our data suggest that...
Abstract Dendritic cell (DC)–based vaccines are promising immunotherapies for cancer. Although DC-based therapies known to activate tumor-specific T cells, the interplay between DCs and NK cells in this setting is not fully understood. In study, we demonstrated a novel TLR7/ mitochondrial reactive oxygen species (mROS)/IL-12 axis that drives potent responses against tumors. We showed TLR7 activation by imiquimod peripheral blood monocyte-derived CD11c+ triggered mROS production, leading...
Integrative medicine practices, such as Ayurveda, are popular in India and many South Asian countries, yet basic research to investigate the concepts, procedures, medical benefits of ayurvedic products has received little attention is not fully understood. Here, we report a functional nanodiamond-based traditional Ayurvedic herbomineral formulation, Heerak Bhasma (Ayu_ND), for treatment solid tumors called Dalton's lymphoma generated CD1 mice. Ayu_ND-mediated immunostimulation significantly...
Peroxidases are a heterogeneous family of enzymes that have diverse biological functions. Ascorbate peroxidase is redox enzyme reduced by trypanothione, which plays central role in the defense system Leishmania . In view developing new and novel therapeutics, we performed silico studies order to search for ligand library identify drug candidates their physiological roles against promastigotes intracellular amastigotes donovani
Abstract The presence of ERG gene fusion; from developing prostatic intraepithelial neoplasia (PIN) lesions to hormone resistant high grade prostate cancer (PCa) dictates disease progression, altered androgen metabolism, proliferation and metastasis 1–3 . driven transcriptional landscape may provide pro-tumorigenic cues in overcoming various strains like hypoxia, nutrient deprivation, inflammation oxidative stress. However, insights on the independent regulation function during stress are...
Single crystal X-ray structurally characterized poly-nuclear Cu(<sc>ii</sc>) complex (M1) selectively and spatially interacts with Cytochrome <italic>C</italic> (Cyt <italic>C</italic>) to allow fluorescence imaging of intracellular translocation events in live cells during apoptotic process.
We fabricated bilirubin–bovine serum albumin (BR–BSA) nanocomplexes as candidates for the delivery of 5-fluoro-2-deoxyuridine (5FUdr) against experimental murine lymphoma. BR was attached to 5FUdr via acid-labile ester bonds mimicking small-molecule drug conjugates. The construct self-assembled with BSA through strong noncovalent interactions high occupancy in core and labeled folic acid (FA) target cancer cells. BR–5FUdr–BSA–FA nanoconstruct exhibits excellent biocompatibility, prevents...
Abstract We developed ZnO‐assisted 1393 bioactive glass‐based scaffold with suitable mechanical properties through foam replica technique and observed to be for bone tissue engineering application. However, the scaffolds' ability facilitate cellular infiltration integration was further assessed in vivo studies animal model. Herein, pure glass (BG) glass‐ (ZnBGs; 1, 2, 4 mol% ZnO substitution SiO 2 BG is named as Z1BG, Z2BG, Z3BG, respectively) based scaffolds were prepared sol–gel route,...
Abstract Melatonin, a neuro hormone, has been shown to activate human monocytes and induce their cytotoxic properties in addition the production of IL-1, IL-6, TNF-α. The molecular mechanisms involved melatonin dendritic cell interactions are largely unknown. In this study, we performed comprehensive RNA sequencing (RNA-seq)-based analysis monocyte-derived cells across different stimulations. We profiled gene expression changes among naïve DCs along with generated (MDCs) matured (DCMs)....