A5101680848- Vitamin C and Antioxidants Research
- Parkinson's Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Clinical practice guidelines implementation
- Inflammatory Myopathies and Dermatomyositis
- Advanced MRI Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Cerebrovascular and Carotid Artery Diseases
- Chronic Lymphocytic Leukemia Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Nutrition and Health in Aging
- Intracranial Aneurysms: Treatment and Complications
- Viral Infections and Immunology Research
- Computational Drug Discovery Methods
- Hepatitis B Virus Studies
- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
- Cardiac, Anesthesia and Surgical Outcomes
- Parvovirus B19 Infection Studies
- Restless Legs Syndrome Research
- RNA regulation and disease
- Antioxidant Activity and Oxidative Stress
Shizuoka General Hospital
2012-2024
Gachon University
2017
Yongin Mental Hospital
2010
Gyeongsang National University Hospital
2001
Although D2/3 agonists have been used as a first-line medication for idiopathic restless legs syndrome (iRLS), findings on receptors inconsistent. Here, we aimed to clarify the contribution of receptor function clinical symptoms iRLS by comparing binding potential (BP ND ) [ 11 C]raclopride with improvements after stimulation pramipexole. Eight drug-naïve, patients and eight age-matched healthy subjects were scanned positron emission tomography (PET). After PET scans, all received...
We previously reported lower lymphocyte vitamin C levels in individuals with type 2 diabetes mellitus and severe Parkinson's disease. Oxidative stress has been proposed to play a key role the progression of Alzheimer's Thus, objective this study was investigate association between peripheral cognitive dysfunction Fifty disease being treated at Shizuoka General Hospital were consecutively enrolled from December 2009 March 2015 (76.0±9.7 y age [mean±SD]; 32 men 18 women; Mini-Mental State...
Abstract Degos disease is a rare vasculopathy with poor prognosis. Here, we report case of 17‐year‐old Japanese male who exhibited progressive deterioration neurological symptoms despite treatment eculizumab and beraprost. We also detailed radiological findings including brain magnetic resonance imaging perfusion computed tomography, hereby suggest the importance study in detecting early changes associated disease.
症例は78歳男性.亜急性に進行する近位筋の筋力低下と嚥下困難感が出現した.筋病理での炎症細胞浸潤を伴わない筋壊死再生所見と抗signal recognition particle(SRP)抗体陽性から抗SRP抗体陽性ミオパチーと診断し,プレドニゾロンとアザチオプリンの併用療法で血清CK値と臨床症状は軽快したが,1年後に増悪した.蛋白電気泳動検査でIgG(κ及びλ)型M蛋白陽性であり,筋病理で筋内の血管と筋線維辺縁にアミロイド沈着を認め,かつ免疫染色で抗λ抗体陽性を確認し,アミロイドミオパチーと診断した.全身性ALアミロイドーシスへの治療で症状は改善した.治療反応性よりアミロイドーシスが主病態と考えたが,二つのミオパチー病態を呈した意義について検討した.
【背景・目的】静岡イーツーネット脳卒中医療連携システムの予防連携の有効性を検討するため，診断群分類包括評価データを基に脳卒中の再発入院に影響する因子を多施設で検討した．【方法】対象は5.5 年間に当医療連携システムに参加している3 つの急性期総合病院に入院し生存退院した急性期脳卒中患者5254 例．性別，年齢，救急搬送の有無，病型，在院日数，転帰，退院先，連携登録の有無と再発入院の関係を検討した．【結果】単変量解析では再入院患者は非再入院患者に比べ有意に救急搬送率と連携登録率が低く，自宅退院率と虚血性脳卒中率が高かった．各項目を多重解析で補正したハザード比は，自宅退院率：1.41（1.02–1.94），虚血性脳卒中率：1.61（1.11–2.33），連携登録率0.65（0.45–0.93）であった．【結論】脳卒中予防連携登録は脳卒中再入院予防に寄与する独立した因子である可能性が示唆された．