A5015908289- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Cervical Cancer and HPV Research
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Child and Adolescent Psychosocial and Emotional Development
- Child and Adolescent Health
- Economic and Financial Impacts of Cancer
- Esophageal Cancer Research and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Advances in Oncology and Radiotherapy
- Suicide and Self-Harm Studies
- Multiple and Secondary Primary Cancers
- Adolescent and Pediatric Healthcare
- Lung Cancer Research Studies
- Mental Health Treatment and Access
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Prostate Cancer Treatment and Research
- Gastric Cancer Management and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Pharmaceutical Practices and Patient Outcomes
- Neuroendocrine Tumor Research Advances
Nottingham Biomedical Research Centre
2023
Nottingham University Hospitals NHS Trust
2023
University of Nottingham
2019-2023
National Institute for Health Research
2023
Public Health England
2014-2018
National Cancer Registration Service
2016-2018
King's College London
2004-2015
London Cancer
2011-2014
Centre de recherche en Epidémiologie et Santé des Populations
2006-2007
<h3>Objective</h3> This study assessed the associations between hospital volume, resection rate and survival of oesophageal gastric cancer patients in England. <h3>Design</h3> 62 811 diagnosed with or 2004 2008 were identified from a national population-based registration Hospital Episode Statistics-linked dataset. Cox regression analyses used to assess all-cause mortality according volume rate, adjusting for case-mix variables (sex, age, socioeconomic deprivation, comorbidity type cancer)....
Background Lung cancer outcomes in the UK are worse than many other developed nations. Symptom awareness campaigns aim to diagnose patients at an earlier stage improve outcomes. Methods An early diagnosis campaign for lung commenced Leeds, 2011 comprising public and primary-care facing components. Rates of community referral chest X-ray (TNM seventh edition) presentation were collected from 2008 2015. Linear trends assessed by χ 2 test trend proportions. Headline figures presented 3 years...
Objectives Cancer stage at diagnosis is a determinant of treatment options and survival. Previous research has shown differences in barriers to presentation with cancer between ethnic groups. The completeness quality ethnicity data improved markedly over recent years England, allowing for comparison distributions This study aimed assess relationships group two outcomes: unknown late (stages 3 4) cancer, after adjustment confounders. Design setting A retrospective secondary analysis using...
Studies from the US have shown variations in breast cancer incidence, stage distribution, treatment and survival between ethnic groups. Data on 35 631 women diagnosed with South East England 1998 2003 self-assigned ethnicity information available were analysed. Results are reported for White, Indian, Pakistani, Bangladeshi, Black Caribbean, African Chinese women. Age-standardised incidence rate ratios, patterns of disease at diagnosis, treatment, overall cancer-specific examined. All groups...
Extrapulmonary small cell carcinoma (EPSCC) is a rare cancer and few studies describe its epidemiology. Our objectives were to compare the incidence survival of EPSCC in South East England with lung (SCLC), determine most common anatomical presenting sites for by disease stage site diagnosis. We used data from Thames Cancer Registry database between 1970 2004 incidence, sites, site, EPSCC. 1618 patients registered identified. calculated age-standardised rate using European standard...
Background The use of antidepressants in children and adolescents remains controversial. We examined trends over time variation antidepressant prescribing young people England whether the drugs prescribed reflected UK licensing guidelines. Methods findings QResearch is a primary care database containing anonymised healthcare records 32 million patients from more than 1,500 general practices across UK. All eligible aged 5–17 years 1998–2017 were included. Incidence prevalence rates...
Breast screening uptake in London is below the Government's target of 70% and we investigate whether ethnicity affects this. Information on for individual women invited unavailable, so use an area-based method similar to that routinely used derive a geographical measure socioeconomic deprivation.We extracted 742,786 observations attendance routine appointments between 2004 2007 collected by Quality Assurance Reference Centre. Each woman was assigned lower super output (LSOA) based her...
Objectives Understanding barriers to early diagnosis of symptomatic breast cancer among Black African, Caribbean and White British women in the UK. Design In-depth qualitative interviews using grounded theory methods identify themes. Findings validated through focus groups. Participants 94 aged 33–91 years; 20 diagnosed with were interviewed. Fourteen African (n=19) without (n=15) participated six Setting Eight centres/hospital trusts London (n=5), Somerset (n=1), West Midlands (n=1) Greater...
Objective To use newly available self-assigned ethnicity information to investigate variation in breast cancer screening uptake for women from the 16 specific ethnic groups within broad Asian, Black and White that previous studies report. Setting National programme services London. Participants 655 516 female residents aged 50–69, invited between March 2006 December 2009. Ethnicity was 475 478 (72.5%). British were largest group (306 689, 46.8%), followed by Indian (34 687, 5.3%), Other (30...
Data linkage studies find that depression before or after a breast cancer diagnosis predicts reduced survival. This study aimed to determine whether bipolar recorded in routine hospital admission data independently survival English patients and onset relation is significant.Data on 77,173 women diagnosed with (ICD-10 C50) South East England, 2000-2009, were included. Of these, 131 had of affective disorder F31) 955 (either depressive episodes F32) F33)) Hospital Episode Statistics between 3...
In the re-organisation of cancer registration in England 2012, a high priority was given to recording stage and other prognostic clinical data items.We extracted 86 852 breast records for women resident diagnosed during 2012-2013. Information on age, ethnicity, socio-economic status, comorbidity, tumour stage, grade, morphology oestrogen, progesterone HER2 receptor status included. The two-year cumulative risk death from any cause estimated with Kaplan-Meier method, univariate multivariate...
This study aimed to determine whether the management and survival of patients with lung cancer varied among 26 health authorities in South East England. The Thames Cancer Registry identified diagnosed (ICD-10 codes C33–C34) between 1995 1999. After excluding death certificate only patients, 32 818 (81%) were analysed. proportions receiving active treatment 5 17% for non-investigative surgery, 4 any chemotherapy, 8 30% radiotherapy 15 42% treatment. One-year patient ranged from 11 34%. There...
We aimed to compare trends in place of cancer death with the growth palliative care and nursing home services, investigate demographic, disease-related area influences on individual death, using registration data for 216404 patients breast, lung, colorectal prostate aggregate services South East England. Between 1985 1994 there was a trend away from hospital (67–44%), (17–30%) hospice (8–20%). After 1995, this partly reversed. By 2002, rose 47%, dropped 23%, remained stable 3 8%. Numbers...
Abstract Background Medication reviews in primary care provide an opportunity to review and discuss the safety appropriateness of a person’s medicines. However, there is limited evidence about access impact routine medication for older adults general population, particularly UK. We aimed quantify proportion people aged 65 years over with recorded 2019 describe changes numbers types medicines prescribed following review. Methods used anonymised electronic health records from UK’s Clinical...
Culturally safe approaches to health care are fundamental addressing Indigenous-specific racism and improving experiences outcomes for Indigenous peoples. However, historical structural barriers in British Columbia, Canada mean that services not consistently or predictably provided a culturally manner as people cross from Indigenous-led mainstream providers who serve communities. The Nuu-chah-nulth Patient Voices Project was participatory research-to-action project which aimed facilitate...
There is growing evidence that the palliative care needs of certain people, such as those from minority ethnic groups, are not being met. The aim this study was to investigate whether place death cancer differs between groups. A total 101,516 patients resident in South East England and who died lung, colorectal, breast or prostate 1998 2006 were extracted Thames Cancer Registry database. Ethnicity data available for 68,804 (68%). odds ratios (ORs) a hospice, at home hospital calculated....
It has been proposed that greater availability of primary medical care practitioners (GPs) contributes to better population health. We evaluated whether measures the supply and structure services are associated with health indicators after adjusting for confounding.Data characteristics registered patients were analysed 99 authorities in England 1999. Health as dependent variables included standardised mortality ratios (SMR), hospital admission rates, conceptions under age 18 years. Linear...
Factors influencing the use of chemotherapy for initial (6 months) treatment lung cancer in South East England were investigated. The variables explored as possibly sex, age, year diagnosis, type cancer, stage, index multiple deprivation and network residence. Chi2 analysis multivariate logistic regression models used to examine effect each on chemotherapy. results showed a highly significant trend over time; adjusted proportion patients receiving increasing from 13.6% 1994 29.3% 2003....
This study investigated the variation in incidence of all, and six subgroups of, oesophageal gastric cancer between ethnic groups.Data on all patients diagnosed 2001 2007 England were analysed. Self-assigned ethnicity from Hospital Episode Statistics dataset was used. Male female age-standardised rate ratios (IRRs) calculated for each group, using White groups as references.Ethnicity information available 83% (76 130/92 205). men had a higher cancer, with IRR other ranging 0.17 95%...
Triple negative breast cancer (TNBC) constitutes 10-15% of female cancers, and clinical guidelines recommend treatment with chemotherapy surgery. We examined the recorded survival women TNBC in a population-based sample within UK.Cancer registration data for North East London diagnosed between 2005 2007 were supplemented pathology on hormone receptor status to determine triple status. Receipt surgery, chemotherapy, radiotherapy, therapy, or surgery plus according was assessed using logistic...