A5079730894- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Cytokine Signaling Pathways and Interactions
- Diet and metabolism studies
- Lung Cancer Treatments and Mutations
- Gut microbiota and health
- Bee Products Chemical Analysis
- Cancer-related gene regulation
- Insect and Pesticide Research
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Multiple and Secondary Primary Cancers
- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
- Employment and Welfare Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Healthcare professionals’ stress and burnout
- Galectins and Cancer Biology
Medical University of Lodz
2015-2025
Health Net
2023
University of Zielona Góra
2023
Toronto General Hospital
2021
Warsaw University of Technology
2017-2019
Toronto Western Hospital
2012
University Health Network
2012
University of Toronto
2012
Interactions between light and various cells in cultures, such as bacteria or mammalian cells, are widely applied for optical sensors optofluidic systems. These microorganisms need to be kept proper aqueous media, referred buffers cell culture that required, respectively, stable storage delivering biochemical nutrients their growth. When experiments numerical analyses on devices performed, the properties of these media usually considered similar those pure water, with negligible influence...
Olive oil application in the cosmetic industry may be extended by its ozonation, bringing about new properties and increased stability. treated with 0.04 mole O3 or 0.10 per 100 g was subjected to chemical parameters evaluation composition scrutinizing gas chromatography–mass spectrometry (GC-MS) headspace solid-phase microextraction (HS-SPME) GC-MS analysis. The biological activity of refined ozonated included their antimicrobial agar diffusion method cytotoxicity MTT assay towards two...
Lactic acid bacteria (LAB) are widely used probiotics and offer promising prospects for increasing the viability of honeybees. Thus, probiotic potential 10 LAB strains was determined, which in our previous studies showed most potent protective abilities. In current study, we investigated various properties candidates. The tested varied susceptibility to antibiotics. Isolates high sugar syrups gastrointestinal conditions. None exhibited β-hemolytic activity, mutual antagonism, mucin...
Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a potent immunoregulatory molecule that downregulates T-cell activation and thus influences the antitumor immune response. CTLA-4 polymorphisms are associated with various cancers, mRNA/protein increased expression found in several tumor types. However, most of studies based on peripheral blood mononuclear cells, much less known about relationship between expression, especially gene its polymorphic variants cancer tissue. In our study...
miRNAs control important cellular functions including angiogenesis/angiostasis or fibrosis and reveal altered expression during pathological processes in the lung. The aim of study was to investigate selected (miR-let7f, miR-15b, miR-16, miR-20a, miR-27b, miR-128a, miR-130a, miR-192 miR-221, miR-222) patients with pulmonary sarcoidosis (n = 94) controls 50). assessed by q-PCR BALF cells peripheral blood lymphocytes (PB lymphocytes). For statistical analysis, Kruskal–Wallis test, Mann–Whitney...
Lactic acid bacteria (LAB) are an essential part of the microbiota digestive tract honeybees (Apis mellifera L.). Antagonistic activity 103 LAB strains (isolates from different environments) against 21 honeybee pathogens/opportunistic pathogens (with agar slab method) was screened. The growth Paenibacillus genus inhibited to most extent. highest antagonistic demonstrated by Lacticaseibacillus casei 12AN, while lowest Apilactobacillus kunkeei DSM 12361, a species naturally inhabiting gut....
The interleukin (IL)-4/IL-13/signal transducer and activator of transcription (STAT) 6 signaling pathway the SOCS3 gene, one its main regulators, constitute an important link between inflammation process in epithelial cells inflammatory-related tumorigenesis. present study is first to evaluate IL-4, IL-13, STAT6, mRNA expression non-small cell lung carcinoma (NSCLC) histopathological subtypes. Gene levels were assessed using TaqMan® probes by quantitative reverse PCR (qRT-PCR) tumor samples...
Background: Lung cancer is one of the most common causes death worldwide with a relatively high fatality rate and mean 5-years survival about 18%. One hallmarks extracellular matrix (ECM) remodeling, which crucial for metastasis. This process may be regulated by miRs targeting metalloproteinases (MMPs) associated ECM breakdown metastatic or blocking action tissue inhibitors (TIMPs). Search early biomarkers essential in detecting non-small cell lung (NSCLC) distinguishing its subtypes:...
INTRODUCTION Signal transducer and activator of transcription (STAT) proteins are critically involved in tumorigenesis various cancers, including lung cancer. OBJECTIVES The aim the study was to analyze immunoexpression levels 3 STAT proteins: STAT3, STAT5, STAT6 their phosphorylated forms (pSTATs), inhibitors PIAS3 SOCS3, additionally cyclooxygenase 2 (COX‑2), as potential diagnostic prognostic markers PATIENTS AND METHODS included 71 patients diagnosed with non- small-cell cancer (NSCLC)....
In lung cancer patients, two complementary abnormalities were found that can cause disruption of the mitochondrial network: increased fusion and impaired fission, manifested by reduced levels FIS1, a division regulator, expression MFN1, mediator. Immunoexpression studies MFN1 FIS1 proteins performed in serum samples obtained from 47 patients with non-small cell (NSCLC) 21 controls. NSCLC immunoexpression protein was significantly higher, level lower than control group (p < 0.01; p 0.001; UMW...
Sunscreen products can protect the skin against harmful effects of UV radiation, including reddening, aging, and cancer. The aim this research was to evaluate photoprotective yeast pulcherrimin, an iron-chelating dipeptide. We first investigated cytotoxicity pulcherrimin produced by
Tumor suppressor gene (TSG) inactivation plays a crucial role in carcinogenesis. FUS1, NPRL2/G21 and RASSF1A are TSGs from LUCA region at 3p21.3, critical chromosomal lung cancer development. The aim of the study was to analyze compare expression levels these 3 NSCLC, as well macroscopically unchanged tissue surrounding primary lesion, look for possible epigenetic mechanism TSG via promoter methylation. Expression 2 DNA methyltransferases, DNMT1 DNMT3B, were assessed using real-time PCR...
Autoimmune thyroid diseases (AITDs), including Hashimoto' s thyroiditis (HT) and Graves' disease (GD), are related to environmental genetic factors. We analyzed the association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene two polymorphisms (+49 A/G, -318 C/T) with HT GD development in Polish children, correlated both production autoantibodies (TPOAb TgAb). The study involved 49 AITD patients (age 10-19) (n=25) or (n=24) 69 healthy controls. SNP genotyping was performed using...
Lactic acid bacteria (LAB) naturally inhabits the organisms of honeybees and can exhibit adhesive properties that protect these insects against various pathogenic microorganisms. Thus, cell surface (auto-aggregation, co-aggregation, hydrophobicity) LAB to two abiotic (polystyrene glass) four biotic (collagen, gelatin, mucus, intestinal Caco-2 cells) surfaces were investigated. Additionally, anti-adhesion activity eradication honeybee pathogen biofilms by metabolites (culture supernatants)...
Candidiasis is one of the most frequent infections worldwide. In this study, antimicrobial properties six strains belonging to Metschnikowia pulcherrima clade were evaluated against twenty Candida and Candida-related Filobasidiella neoformans var. bacillispora (syn. Cryptococcus neoformans) different origins, employing agar cross method. The toxic effect pulcherrimin, a red metabolite that responsible for activities spp., was in various experimental models. results tests showed selected M....
The chronic course of pulmonary sarcoidosis can lead to lung dysfunction due fibrosis, in which the signalling pathways TGF-β/Smad and VEGF-A may play a key role.We evaluated immunoexpression TGF-β1, Smad2, 3, 7, serum bronchoalveolar lavage (BAL) fluid patients (n = 57) classified according presence parenchymal involvement (radiological stage I vs. II-III), acute insidious onset, function test (LFT) results, calcium metabolism parameters, percentage BAL lymphocytes (BAL-L%), CD4(+)/CD8(+)...
FHIT is a tumor suppressor gene that frequently silenced in non-small cell lung cancer (NSCLC) and also preneoplastic lesions. Promoter hypermethylation was previously observed NSCLC, its epigenetic silencing, on mRNA or protein level, proposed to predict NSCLC outcome. In the present study we evaluated relationship between expression level promoter methylation, immunoexpression level. The aim of this analyze usefulness as early differentiating biomarker patients. Lung tissue specimens were...