A5073558067- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Inflammatory Bowel Disease
- High Altitude and Hypoxia
- Nerve injury and regeneration
- Microscopic Colitis
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Asthma and respiratory diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Adolescent and Pediatric Healthcare
- Health and Lifestyle Studies
- Cardiovascular and Diving-Related Complications
- Iron Metabolism and Disorders
- Whipple's Disease and Interleukins
- Neuropeptides and Animal Physiology
- IL-33, ST2, and ILC Pathways
- Biochemical effects in animals
- Sleep and Work-Related Fatigue
Medical University of Lodz
2018-2025
California Center for Sleep Disorders
2023
SleepMed
2023
Obstructive sleep apnea (OSA) is a chronic condition that characterized by recurrent pauses in breathing during causing intermittent hypoxia. The main factor responsible for oxygen metabolism homeostasis hypoxia-inducible 1 (HIF-1), comprised of 2 subunits: α (oxygen sensitive) and β. aim the study was to investigate HIF-1α serum protein level mRNA expression patients with OSA healthy control group determine their evening-morning variation association polysomnography parameters.Eighty-four...
Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia and associated with the disruption of circadian rhythm. The study aimed to assess relationship between hypoxia-inducible factor (HIF) subunits, clock proteins, polysomnography (PSG) variables, in healthy individuals severe OSA patients. included 20 individuals, who underwent PSG were divided into group (n = 10; AHI ≥ 30) control < 5) based on apnea-hypopnea index (AHI). All participants had their peripheral blood...
Background.Obstructive sleep apnea (OSA) is one of the risk factors for diabetes mellitus type 2 (DM2).As OSA associated with disruption circadian rhythm, it affects clock proteins, including neuronal PAS domain protein (NPAS2) and nuclear receptor subfamily 1 group D member (Rev-Erb-α).These proteins have been shown to be related metabolic abnormalities, i.a., insulin resistance.Objectives.The present pilot study aimed investigate NPAS2 Rev-Erb-α serum levels in groups patients severe...
Abstract Sleep deprivation (DS) is the forced elimination of sleep. While brain-derived neurotrophic factor (BDNF) has been extensively studied in context mood changes following DS, role other neurotrophins remains elusive. This study explores impact DS on BDNF, glial cell line-derived (GDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4) at mRNA protein level, considering their potential links to disturbances. The involved 81 participants subjected polysomnography (PSG) DS. Blood samples,...
The causes of disordered sleep, frequently reported by patients with inflammatory bowel diseases (IBD), are poorly understood. study aimed to evaluate sleep quality in IBD and identify factors affecting their sleep. (n = 133) healthy controls (HC; n 57) were included the completed questionnaires (Pittsburgh Sleep Quality Index (PSQI), Athens insomnia scale (AIS), Epworth sleepiness (ESS)), Beck Depression Inventory (BDI), pain scales (Visual Analogue Scale Laitinen Pain Scale). attained...
Abstract Obstructive sleep apnea (OSA) is characterized by co-occurrence with affective disorders. Our study aims to investigate the association of circadian clock gene expressions, and presence severity depressive symptoms in OSA patients. The included 184 individuals, who underwent polysomnography (PSG) had their peripheral blood collected evening before morning after PSG. Patients were divided into two groups: (apnea-hypopnea index (AHI) > 5) control group (AHI < 5). RNA was...
Obstructive sleep apnea (OSA) is a recognized independent risk factor for metabolic disorders, type 2 diabetes mellites (DM2) in particular. Therefore, the study aimed to assess influence of nocturnal oxygen saturation parameters on onset DM2 among OSA patients. The consisted 549 participants, who underwent polysomnography examination. Based hypopnea index (AHI), 465 patients were diagnosed with OSA. One hundred and seven individuals had comorbid DM2. Cox regression models used effect...
The molecular underpinnings of insufficient sleep remain underexplored, with disruptions in the neurotrophic signaling pathway emerging as a potential explanation. Neurotrophins (NTs), including brain-derived factor (BDNF), neurotrophin-3 (NT3), neurotrophin 4 (NT4), and glial-cell-line-derived growth (GDNF), play crucial roles nerve cell repair. However, their associations patterns are poorly understood. This study aimed to investigate relationship between chosen neurotrophins objective...
Background: Hypoxia-inducible factor 1 (HIF-1) affects the circadian clock in obstructive sleep apnea (OSA) and may have a bidirectional relationship with mechanisms. This study examined link between HIF-1 OSA patients versus controls. Methods: 70 participants underwent polysomnography (PSG), were assigned into (apnea–hypopnea index (AHI) ≥ 5, n = 54) or control (AHI < 16) groups. BMAL1 (brain muscle ARNT like 1), CLOCK (circadian locomotor output cycles kaput), PER1 (period CRY1...
Introduction: Obstructive sleep apnea (OSA) is a disorder that, apart from somatic sequelae, increases the risk of developing psychiatric conditions. Brain-derived neurotrophic factor (BDNF) signaling pathway involved in pathophysiology depression and insomnia. Therefore, study aimed to investigate differences concentrations BDNF proBDNF patients with OSA healthy individuals, evaluate diurnal changes these proteins, assess correlations symptoms. Methods: Sixty individuals following...
Background/Objectives: Serotonin and the serotonin transporter (SERT) may have a multifaceted, but not fully understood, role in obstructive sleep apnea (OSA) its impact on mental health this group of patients. This study aimed to investigate changes their association with depressive insomnia symptoms. Methods: included 76 participants (OSA group: n = 36, control (CG): 40) who underwent polysomnography, while venous blood samples (evening morning) were analyzed for SERT using ELISA. mRNA...
Obstructive sleep apnea (OSA) is associated with circadian rhythm dysregulation plausibly through affecting clock genes. The study's purpose was to investigate the effect of one-night continuous positive airway pressure treatment (CPAP treatment) on genes: BMAL1, CLOCK, CRY1, and PER1 at mRNA protein levels. study included 30 OSA patients, who underwent diagnostic polysomnography (PSG) next a effective CPAP PSG monitoring (CPAP). blood collected in evening before morning after CPAP. Protein...
Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurring upper airway obstructions, leading to disrupted and systemic complications. The complexity of OSA suggests intricate interactions between neuromodulators circadian clock genes. This study aimed explore the expression levels rhythm genes neurotrophins (NTs) in patients compared controls. Participants (166 patients, 64 controls) were enrolled. Blood samples collected post-polysomnography (PSG), underwent RNA...