A5020074944- Reproductive Biology and Fertility
- Ovarian function and disorders
- Sperm and Testicular Function
- Marine Invertebrate Physiology and Ecology
- Renal and related cancers
- Marine Ecology and Invasive Species
- Assisted Reproductive Technology and Twin Pregnancy
- Marine Toxins and Detection Methods
- Mitochondrial Function and Pathology
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Reproductive Health and Technologies
- Planarian Biology and Electrostimulation
- Erythrocyte Function and Pathophysiology
- Advanced Image Processing Techniques
- Image Processing Techniques and Applications
- Image and Video Quality Assessment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pluripotent Stem Cells Research
- Legal and Policy Issues
- Metabolism and Genetic Disorders
- RNA modifications and cancer
- Genomics and Rare Diseases
- Transgenic Plants and Applications
- Genomic variations and chromosomal abnormalities
Royal Women's Hospital
2024
The University of Melbourne
2024
University of Pittsburgh
2024
Skolkovo Institute of Science and Technology
2021-2023
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2017-2023
Presidential Executive Office
2021
University of Vienna
2018-2019
Lomonosov Moscow State University
2018-2019
All-Russian Scientific Research Institute of Refrigeration Industry
2019
Moscow State University
2018
Bioethical and legal issues of three-dimensional (3D) bioprinting as the emerging field biotechnology have not yet been widely discussed among bioethicists around world, including Russia. The scope 3D includes only advanced technologies human tissues organs printing but also raises a whole layer interdisciplinary problems modern science, technology, bioethics, philosophy. This article addresses ethical artificial organs.
Significance Embryonic development of any animal species is a robust series morphogenetic events tightly controlled by molecular signals. However, the variety developmental trajectories undertaken different members same phylum suggests that normal in each particular might involve only subset capacities available to highly developmentally plastic embryonic cells. Here we show that, faced new context, aggregates dissociated gastrula cells sea anemone Nematostella vectensis use an alternative...
To evaluate if it is safe and effective to transfer poor quality embryos.It was a retrospective analysis using individual patient data with positive controls. All patients undergoing embryo transfers of embryos on day 3 or 5 as part fresh In Vitro Fertilization (IVF) cycles performed between 2012 2016. This study assessed total 738 from 488 IVF programs. 261 were (402 transferred) 227 (336 transferred). Control group consisted 9893 fair good 5994 Outcome rates compared two-tailed Fisher...
Morphogenesis is a shape-building process during development of multicellular organisms. During this process, the establishment and modulation cell-cell contacts play an important role. Cadherins, major cell adhesion molecules, form adherens junctions connecting epithelial cells. Numerous studies Bilateria have shown that cadherins are associated with regulation differentiation, shape changes, migration tissue morphogenesis. To date, role in non-bilaterians unknown. Here, we study expression...
Morphogenesis is a shape-building process during development of multicellular organisms. During this the establishment and modulation cell-cell contacts play an important role. Cadherins, major cell adhesion molecules, form adherens junctions connecting epithelial cells. Numerous studies in Bilateria have shown that cadherins are associated with regulation differentiation, shape changes, migration tissue morphogenesis. To date, role Cadherins non-bilaterians unknown. Here, we study...
The editing of the CCR5 gene in CD4+ T cell genome is an effective way preventing HIV-1 proliferation. Very similar strategies can be used to protect fetus HIV-infected female showing a weak response antiretroviral therapy. Inducing “natural” CCR5delta32 mutation zygote may guard against HIV infection both utero and at birth. In this study, we optimize CRISPR-Cas9 system induce homozygous 32-nt deletion naturally occurring allele human S-phase. Edits were done abnormal tripronuclear zygotes...
Interleukin 8 (IL-8), vascular endothelial growth factor A (VEGFA), its receptors 1 (VEGFR1) and 2 (VEGFR2) are associated with ovarian hyperstimulation syndrome (OHSS) pathophysiological mechanisms. The aim of this study was to evaluate the concentrations these cytokines depending on way ovulation triggering.A total 51 high-responder patients underwent IVF program received gonadotropin-releasing hormone agonists (GnRHa) trigger + 1500 IU human chorionic gonadotropin (hCG) support oocyte...
Super-resolution (SR) has become a widely researched topic in recent years. SR methods can improve overall image and video quality create new possibilities for further content analysis. But the mainstream focuses primarily on increasing naturalness of resulting despite potentially losing context accuracy. Such may produce an incorrect digit, character, face, or other structural object even though they otherwise yield good visual quality. Incorrect detail restoration cause errors when...
Objective In vitro maturation of oocytes collected from oophorectomy samples might be a promising approach in the field oncofertility. this study, we evaluate feasibility patients with ovarian tumors. Methods This prospective observational study included 27 malignant Patients underwent and tissue was examined for presence immature cumulus-oocyte complexes. These were matured 48 hours. Mature vitrified or used fertilization. Serum anti-müllerian hormone (AMH) levels analyzed 11 cancer antigen...
Изменение гена CCR5 путем редактирования генома CD4+-T-клеток является одним из способов предотвращения распространения ВИЧ-1-инфекции. Однако похожая стратегия защиты от ВИЧ может быть использована и для плода ВИЧ-инфицированных женщин со слабым ответом на антиретровирусную терапию. Создание «естественного» аллеля CCR5delta32 стадии зиготы защитить плод ВИЧ-инфекции во время внутриутробного развития родов. Целью данного исследования была оптимизация системы CRISPR-Cas9 под создание...
The major limitations associated with gonadotropin-releasing hormone agonist (GnRHa) triggering are inferior clinical outcomes in fresh embryo transfer cycles caused by luteal phase insufficiency following the GnRHa triggering. We included 153 high-risk patients this study. In group I, received trigger + 1,500 IU human chorionic gonadotropin (hCG) support on oocyte pick-up (OPU) day; II, had a dual (GnRHa hCG); and III (control), 10,000 hCG was prescribed for final maturation. levels of LH,...