A5031548141- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Advanced Fluorescence Microscopy Techniques
- Medical Imaging Techniques and Applications
- Cancer, Lipids, and Metabolism
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cell Image Analysis Techniques
- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Single-cell and spatial transcriptomics
- Dental Education, Practice, Research
- Orthodontics and Dentofacial Orthopedics
- Photodynamic Therapy Research Studies
- Atmospheric and Environmental Gas Dynamics
- Biocrusts and Microbial Ecology
- Dental materials and restorations
- Photosynthetic Processes and Mechanisms
- Nanoparticle-Based Drug Delivery
- Algal biology and biofuel production
- Dental Implant Techniques and Outcomes
- Reproductive Biology and Fertility
- Atmospheric Ozone and Climate
- bioluminescence and chemiluminescence research
- ATP Synthase and ATPases Research
- Innovations in Medical Education
Sechenov University
2022-2024
Lomonosov Moscow State University
2017-2022
Molecular, morphological, and physiological heterogeneity is the inherent property of cells which governs differences in their response to external influence. Tumor cell metabolic a special interest due its clinical relevance tumor progression therapeutic outcomes. Rapid, sensitive, noninvasive assessment great demand for biomedical sciences. Fluorescence lifetime imaging (FLIM), an all-optical technique, emerging tool sensing quantifying cellular metabolism by measuring fluorescence decay...
The extracellular matrix (ECM) plays an important role in regulation of many aspects tumor growth and response to therapies. However, the specifics interaction chemotherapeutic agents with cancer cells presence collagen, major component ECM, is still poorly investigated. In this study, we explored distribution doxorubicin (DOX) its effects on cells' metabolism collagen different structures 3D models. For this, a combination second harmonic generation imaging multiphoton fluorescence...
Heterogeneity of tumor metabolism is an important, but still poorly understood aspect biology. Present work focused on the visualization and quantification cellular metabolic heterogeneity colorectal cancer using fluorescence lifetime imaging (FLIM) redox cofactor NAD(P)H. FLIM-microscopy NAD(P)H was performed in vitro four cell lines (HT29, HCT116, CaCo2 CT26), vivo types tumors mice ex patients’ samples. The dispersion bimodality decay parameters were evaluated to quantify intercellular...
Heterogeneity of tumor metabolism is an important, but still poorly understood aspect biology. Present work focused on the visualization and quantification cellular metabolic heterogeneity colorectal cancer using fluorescence lifetime imaging (FLIM) redox cofactor NAD(P)H. FLIM-microscopy NAD(P)H was performed in vitro four cell lines (HT29, HCT116, CaCo2 CT26), vivo types tumors mice ex patients’ samples. The dispersion bimodality decay parameters were evaluated to quantify intercellular...
The extracellular matrix (ECM), in which collagen is the most abundant protein, impacts many aspects of tumor physiology, including cellular metabolism and intracellular pH (pHi), as well efficacy chemotherapy. Meanwhile, role differential cell responses to treatment within heterogeneous environments remains poorly investigated. In present study, we simultaneously monitored changes pHi living colorectal cancer cells vitro upon with a chemotherapeutic combination, FOLFOX (5-fluorouracil,...
Autofluorescence characteristics of the reduced nicotinamide adenine dinucleotide and oxidized flavin cofactors are important for evaluation metabolic status cells. The approaches that involve a detailed analysis both spectral time autofluorescence signals may provide additional insights into biochemical processes in cells biological tissues facilitate transition fluorescence lifetime imaging clinical applications.
Abstract Molecular, morphological and physiological heterogeneity is the inherent property of cells, which governs differences in their response to external influence. The tumor cells metabolic a special interest due its clinical relevance progression therapeutic outcomes. Rapid, sensitive non-invasive assessment great demand for biomedical sciences. Fluorescence lifetime imaging (FLIM), an all-optical technique emerging tool sensing quantifying cellular metabolism by measuring fluorescence...
We aimed to assess the influence of professional dental prophylaxis on translucency and color stability a novel simplified shade nanohybrid composite material. Sixty disks (5 mm in diameter 2 thick) light (n = 30) dark shades were prepared. The specimens randomly divided into following three groups 10) according procedure used: ultrasonic scaling, air-powder polishing with sodium bicarbonate, controls. submitted analysis based CIELab system. Two measurements performed before after 48-h...
Abstract Heterogeneity of tumor metabolism is an important, but still poorly understood aspect biology. Present work focused on the visualization and quantification cellular metabolic heterogeneity colorectal cancer using fluorescence lifetime imaging (FLIM) cofactor NAD(P)H. FLIM-microscopy NAD(P)H was performed in vitro four cell lines, vivo types tumors mice ex patients’ samples. The dispersion bimodality decay parameters were evaluated to quantify intercellular heterogeneity. Our results...
Abstract Heterogeneity of tumor metabolism is an important, but still poorly understood aspect biology. Present work focused on the visualization and quantification cellular metabolic heterogeneity colorectal cancer using fluorescence lifetime imaging (FLIM) redox cofactor NAD(P)H. FLIM-microscopy NAD(P)H was performed in vitro four cell lines, vivo types tumors mice ex patients’ samples. The dispersion bimodality decay parameters were evaluated to quantify intercellular heterogeneity. Our...
Heterogeneity of tumor metabolism is an important, but still poorly understood aspect biology. Present work focused on the visualization and quantification cellular metabolic heterogeneity colorectal cancer using fluorescence lifetime imaging (FLIM) cofactor NAD(P)H. FLIM-microscopy NAD(P)H was performed in vitro four cell lines, vivo types tumors mice ex patients’ samples. The dispersion bimodality decay parameters were evaluated to quantify intercellular heterogeneity. Our results...
Heterogeneity of tumor metabolism is an important, but still poorly understood aspect biology. Present work focused on the visualization and quantification cellular metabolic heterogeneity colorectal cancer using fluorescence lifetime imaging (FLIM) redox cofactor NAD(P)H. FLIM-microscopy NAD(P)H was performed in vitro four cell lines, vivo types tumors mice ex patients’ samples. The dispersion bimodality decay parameters were evaluated to quantify intercellular heterogeneity. Our results...
The modern approach to the treatment of caries requires maximum preservation tooth tissues and pulp viability, for which it is necessary know residual thickness dentin during its removal. Currently existing methods (Cone-beam Computed Tomography, electrical impedance device, optical coherence tomography) are not widely used in clinical practice due laboriousness their use or low accuracy. We evaluated capabilities diffuse reflectance spectroscopy (DRS) method determining dentine situ ....