A5011166283- Aldose Reductase and Taurine
- Endometrial and Cervical Cancer Treatments
- Estrogen and related hormone effects
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Screening and Detection
- HER2/EGFR in Cancer Research
- Uterine Myomas and Treatments
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Rheumatoid Arthritis Research and Therapies
- Endometriosis Research and Treatment
- Hedgehog Signaling Pathway Studies
- Circular RNAs in diseases
- Histone Deacetylase Inhibitors Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pregnancy-related medical research
- Heme Oxygenase-1 and Carbon Monoxide
- Bioactive Compounds and Antitumor Agents
- Cancer Immunotherapy and Biomarkers
- Tuberous Sclerosis Complex Research
- Genomics, phytochemicals, and oxidative stress
- Kruppel-like factors research
- Mechanisms of cancer metastasis
Ljubljana University Medical Centre
2013-2024
Institute of Oncology Ljubljana
2001-2008
Estrogens have important roles in endometrial cancer (EC) and exert biological effects through the classical estrogen receptors (ERs) ERα ERβ, G-protein–coupled ER, GPER. So far, co-expression of these three types ERs has not been studied EC. We investigated ERα, GPER mRNA protein levels, their intracellular distributions EC tissue adjacent control tissue. Compared to tissue, immunoreactivity for was weaker nuclei with minor, but unchanged, cytoplasmic staining; levels showed decreased...
Endometrial cancer is the most common estrogen-dependent gynecological malignancy in developed World. To investigate local formation of estradiol (E2), we first measured concentrations steroid precursor androstenedione (A-dione) and potent estrogen, E2, evaluated metabolism A-dione, estrone-sulfate (E1-S), estrone (E1) cancerous adjacent control endometrium. Furthermore, studied expression key genes for via aromatase sulfatase pathways. A-dione E2 were detected In endometrium, was...
Although aldo-keto reductases (AKRs) have been widely studied in cancer, no study to date has examined the roles of AKR family 1 members B1 (AKR1B1) and B10 (AKR1B10) a large group ovarian cancer patients. AKR1B1 AKR1B10 play significant role inflammation metabolism different chemotherapeutics as well cell differentiation, proliferation, apoptosis. Due these functions, we potential tissue biomarkers. We assessed immunohistochemical levels paraffin sections from 99 patients with high-grade...
Malignant transformation of normal gastric cells is a complex and multistep process, resulting in development heterogeneous tumours. Susceptible genetic background, accumulation changes, environmental factors play an important role carcinogenesis. Single nucleotide polymorphisms (SNPs) mitotic segregation genes could be responsible for inducing the slow process leading to genome instability.We performed case-control study kinases TTK rs151658 BUB1B rs1031963 rs1801376 assess their effects on...
Background: Colorectal cancer (CRC) is one of the most common malignancies in western world. Objective: We aimed to assess first round fecal immunochemical test (FIT)-based National CRC screening program (NCSP). Methods: In NCSP conducted Slovenia, a FIT and colonoscopy for those tested positive was used. The central unit sent 536,709 invitations Slovenian residents age 50 69 years old between 2009 2011. adherence rate 56.9% (303,343 participants). 6.2% (15,310) participants (men, 7.8%;...
The aldo-keto reductase (AKR) superfamily is gaining attention in cancer research. AKRs are involved important biochemical processes and have crucial roles carcinogenesis chemoresistance. enzyme AKR1C3 has many functions, which include production of prostaglandins, androgens estrogens, metabolism different chemotherapeutics; thus implicated the pathophysiology cancers. Endometrial ovarian cancers represent majority gynecological malignancies developed countries. Personalized treatments for...
The roles of aldo-keto reductase family 1 member B1 (AKR1B1) and B10 (AKR1B10) in the pathogenesis many cancers have been widely reported but only briefly studied endometrial cancer. To clarify potential AKR1B1 AKR1B10 as tissue biomarkers cancer, we evaluated immunohistochemical levels paraffin sections from 101 well-characterized patients with endometrioid cancer 12 serous compared them clinicopathological data. Significantly higher were found adjacent non-neoplastic to A trend for better...
The objectives of this study were to assess cancer stem cell-related marker NANOG expression in ovarian serous tumors and evaluate its prognostic significance relation carcinoma.NANOG protein was immunohistochemically evaluated the tissue microarrays 20 patients with benign tumors, 30 borderline 109 carcinomas, from which 106 high-grade 3 low-grade morphology Immunohistochemical reaction scored according signal intensity percentage positive cells tumor samples. Pursuant our summation cell...
The use of tissue microarray (TMA) technology may substantially reduce the costs routine testing breast carcinomas for human epidermal growth factor receptor 2 (HER2) status. After a preliminary pilot study comparing TMA results with those obtained on whole section, which showed an excellent agreement (with kappa values >0.90) both immunohistochemical and fluorescent in situ hybridization (FISH) method, we introduced technique our work. A total 1158 invasive were submitted determination HER2...
We aimed to assess the impact of first three rounds National Colorectal Cancer Screening Program (NCCSP) on CRC incidence and mortality in Slovenia. In NCCSP, we use two fecal immune tests (FITs) if test is positive patient referred colonoscopy. From 2009, invite Slovenian residents aged 50-69 years, one screening round takes 2 years. The response rate was from 56.9 59.9%. FIT 6.0-6.2% (more older patients men; P < 0.05). adenoma detection >51.3% 0.01). 70.3% all cancers diagnosed were...
2DE in combination with MS has facilitated the discovery of several proteins altered abundance gastric cancer. While acidic and wide pH ranges have been widely investigated, analysis alkaline range not specifically performed cancer to date. In present study, we initially optimized (pH 7-11) for tissue samples. Using a modified lysis buffer, analyzed pooled nontumor tumor samples adenocarcinoma. We successfully identified 38 silver-stained spots as 24 different proteins. Four these were...
Endometrial cancer is the sixth most common in women worldwide. It associated with aberrant actions of steroid hormones, estrogens and progesterone, but also enhanced inflammation reduced cellular differentiation. Here, we show data on demographic histopathological characteristics 51 patients endometrial cancer, together correlations between expression 38 genes involved estrogen progesterone actions, differentiation, characteristics. We changes gene these according to clinical patients. This...
<h3>Introduction/Background</h3> Perivascular epithelioid cell tumours (PEComas) are rare mesenchymal identified by their distinct histology and immunophenotype. Majority of described PEComas occurred in the female gynaecological tract, mostly arising uterine corpus, those around 45 classified as malignant. <h3>Methodology</h3> Clinical, imaging, histopathological, treatment follow-up data malignant PEComa (as per modified criteria Bennett) treated between 2018 2023 was retrospectively...
Objectives: The objective of the study was to assess impact an internal quality indicator (QI) audit on level colonoscopies in National Colorectal Cancer Screening Program (NCCSP). Design: Sixty-eight colonoscopists from 29 endoscopic centres participated NCCSP April 2009 January 2015. Controlled QIs were percentage total colonoscopies, adenoma detection rate (ADR), mean per procedure (MAP), positive (MAP+), right-sided ADR, sessile serrated lesion (SSL) rate, and patient responses...
<h3>Introduction/Background*</h3> Endometrial cancer is the most common gynecological diagnosis in developed countries. Personalized treatments for these cancers depend on identification of prognostic and predictive biomarkers that allow stratification patients. The aldo-keto reductase (AKR) superfamily getting attention research, because AKR's involvements important biochemical processes. enzyme AKR1C3 has many functions, which include production prostaglandins, androgens, estrogens,...