Grant Armstrong

ORCID: 0000-0003-4016-6841
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About
Contact & Profiles
Research Areas
  • RNA and protein synthesis mechanisms
  • Protein Structure and Dynamics
  • Lipid Membrane Structure and Behavior
  • Bacteriophages and microbial interactions
  • Microbial Metabolic Engineering and Bioproduction
  • Nanoparticles: synthesis and applications

Lehigh University
2022-2023

We present a comparative all-atom molecular dynamics simulation study of 18 biomembrane systems with lipid compositions corresponding to eukaryotic, bacterial, and archaebacterial membranes together three single-component bilayers. A total 105 types used in this include diverse sterols glycerol-based lipids acyl chains various lengths, unsaturation degrees, branched or cyclic moieties. Our analysis provides deeper insight into the influences on structural mechanical properties these...

10.1021/acs.jcim.1c01514 article EN Journal of Chemical Information and Modeling 2022-02-15

Abstract Protein-protein interactions are essential for various biological processes, including signal transduction, metabolism, vesicle transport, and mitogenic processes. It’s crucial to consider them within the context of their with other proteins understand protein function. Mutations in can affect binding affinity partner by introducing effects, such as changes hydrophobic regions, electrostatic interactions, or hydrogen bonds. Assessing impact mutations on have implications disease...

10.1101/2023.10.26.564257 preprint EN cc-by-nd bioRxiv (Cold Spring Harbor Laboratory) 2023-10-31
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