A5027974431- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Trace Elements in Health
- Apelin-related biomedical research
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects and Assays
- Autophagy in Disease and Therapy
- Dietary Effects on Health
- Ion Channels and Receptors
- Endoplasmic Reticulum Stress and Disease
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Education Practices and Challenges
- Phytochemicals and Antioxidant Activities
- Dermatoglyphics and Human Traits
- Problem Solving Skills Development
- Educational Methods and Analysis
- Postharvest Quality and Shelf Life Management
- Pharmacology and Obesity Treatment
Eskişehir Osmangazi University
2022
Ankara University
2015-2021
British Institute at Ankara
2015
Metabolic syndrome (MetS) is a prevalent risk factor for cardiac dysfunction. Although SGLT2-inhibitors have important cardioprotective effects in hyperglycemia, their underlying mechanisms are complex and not completely understood. Therefore, we examined of SGLT2-inhibitor dapagliflozin (DAPA)-related cardioprotection overweight insulin-resistant MetS-rats comparison with insulin (INSU), behind its glucose-lowering effect. A 28-week high-carbohydrate diet-induced received DAPA (5 mg/kg),...
Abstract The prevalence of death from cardiovascular disease is significantly higher in elderly populations; the underlying factors that contribute to age‐associated decline cardiac performance are poorly understood. Herein, we identify involvement sodium/glucose co‐transporter gene (SGLT2) disrupted cellular Ca 2+ ‐homeostasis, and mitochondrial dysfunction dysfunction. In contrast younger rats (6‐month age), older (24‐month age) exhibited severe ultrastructural defects, including deformed,...
Role of β3 -AR dysregulation, as either cardio-conserving or cardio-disrupting mediator, remains unknown yet. Therefore, we examined the molecular mechanism activation in depressed myocardial contractility using a specific agonist CL316243 overexpressed cardiomyocytes. Since it has been previously shown possible correlation between increased cellular free Zn2+ ([Zn2+ ]i ) and cardiac contractility, first demonstrated relation [Zn2+ , parallel to significant depolarization mitochondrial...
Metabolic syndrome (MetS) became a tremendous public health burden in the last decades. Store-operated calcium entry (SOCE) is unique mechanism that causes influx, which triggered by store depletion. MetS-induced alterations cardiac signaling, especially SOCE are still unclear. Therefore, we aim to examine possible role of and its components (STIM1 Orai1) remodeling.We used male, adult (12 weeks) Wistar albino rats (n = 20). Animals were randomly divided into two groups were: control (C)...
Metabolic syndrome (MetS) is the name for a group of risk factors that raises important heart disease and other health problems. The main features metabolic include insülin resistance hypertension. Although evidence emerging changes in cardiac energy metabolism might contribute to development contractile dysfunction, depressed sarcoplasmic reticulum (SR) function seems be good candidate underlie MetS‐induced dysfunction. Therefore, present study was designed determine whether properties Zn...
Zinc is a vital metal in maintaining cellular functions many cells and Zn 2+ concentration at the nanomolar range resting cardiomyocytes. Very little known about precise mechanisms controlling intracellular free distribution during cardiac function. To understand role of physiology, present study, we measured simultaneously twitch tension action potential (AP) rat ventricular papillary muscles. The amplitude 25% depressed while rates both contraction relaxation are markedly slowed down...
Amaç: Sodyum glukoz ko-transporter (SGLT) inhibitörlerinin diyabetli bireylerde re-absorbsiyonunu inhibe ederek kan şekerini düşürdüğü ileri sürülmektedir.Bu inhibitörlerin kalp fonksiyonu üzerindeki etkileri henüz tam olarak bilinmemesine karşın, Na + /H -değiştokuşçusu (NHE) inhibitörü gibi etkiler gösterebildiği çalışmada, SGLT2-inhibitörü Dapagliflozin (DAPA), in vitro sıçan embriyonik hiperglisemik ventriküler hücrelerine (H9c2-hücre hattı
Beta adrenoceptors (beta-ARs) play important roles in regulation of heart function. The well-known beta-AR-associated signaling is composed a coupled mechanism among both beta1- and beta2-AR stimulatory G protein, while recent studies emphasized the contribution constitutive beta3-AR, thereby initiating additional signalling pathways, particularly under physiopathological conditions. expression level beta3-AR very low normal comparison to others its increased markedly hyperglycemia. In here,...
Objectives: Diabetes mellitus (DM) is presently a worldwide health problem and leads to high risks for cardiovascular disfunction.Besides vascular disorders in dependent diabetic-cardiomyopathy, thrombocyte reactivity developed DM.In this study, we aimed examine the effect of P2Y12 receptor blocker ticagrelor (TICA) on heart function DM rats.Materials Methods: was induced by single-dose streptozotocin (STZ) injection 3-month-old Wistar male rats (250-300g) confirmed blood glucose level,...