A5075269795- Zebrafish Biomedical Research Applications
- Neuroendocrine regulation and behavior
- Mercury impact and mitigation studies
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Heavy Metal Exposure and Toxicity
- Retinal Development and Disorders
- Neurotransmitter Receptor Influence on Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Meningioma and schwannoma management
- Molecular Sensors and Ion Detection
- Malaria Research and Control
- Pituitary Gland Disorders and Treatments
- Stress Responses and Cortisol
- Physiological and biochemical adaptations
- Neurofibromatosis and Schwannoma Cases
- Tendon Structure and Treatment
- Adenosine and Purinergic Signaling
- Spinal Fractures and Fixation Techniques
- Photoreceptor and optogenetics research
- Pain Mechanisms and Treatments
- Bone Tumor Diagnosis and Treatments
- Exercise and Physiological Responses
- Memory and Neural Mechanisms
- Animal Behavior and Reproduction
Universidade Federal do Pará
2016-2025
Hospital Santa Paula
2024
Hospital São Paulo
2024
Centro Universitário do Maranhão
2019
Clinical Research Consortium
2010-2014
Universidade do Estado do Pará
2014
Morpho (United States)
2014
Universidade Federal do Oeste do Pará
2013
Universidade Federal de Minas Gerais
2012
Faculdade de Medicina de Jundiaí
2002-2006
The scototaxis test has been introduced recently to assess anxiety-like phenotypes in fish, including zebrafish. Parametric analyses suggest that represents an approach-avoidance conflict, which hints at anxiety. In this model, white avoidance behavior, while the number of shuttling events activity. Acute or chronic fluoxetine, buspirone, benzodiazepines, ethanol, caffeine and dizocilpine were assessed using light-dark box (scototaxis) fluoxetine treatment did not alter avoidance, but...
A major hindrance for the development of psychiatric drugs is prediction how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report a medium-throughput screen anxiety-like behavior adult zebrafish. The observed phenotypes were clustered according to shared behavioral effects. This barcoding procedure revealed conserved functions anxiolytic, anxiogenic psychomotor stimulating predicted effects poorly characterized compounds on...
The recent introduction of tasks to assess the behavior zebrafish in novel and/or aversive environments has spurred great interest, prompting attempts determine which constructs are modeled by these (e.g., fear, anxiety, or some other construct). A review pharmacological and behavioral experiments indicates that not all testing models equivalent. more precise understanding parameters influence task performance affords a wider selection experimental procedures for investigating particular...
Alarm reactions to a substance secreted by the damaged skin of conspecifics and closely-related species are increasingly being recognized as fear-like responses in fish. The neurochemical underpinnings these effects so far unknown; however, given role serotonergic system on defensive behavior, it is possible that alarm reaction mediated this monoamine. Exposure conspecific (CAS) increased anxiety-like behavior light/dark test zebrafish decreased nocifensive behavior. These were accompanied...
Abstract: Adenosinergic systems have been implicated in anxiety‐like states, as caffeine can induce a state of anxiety human beings. Caffeine is an antagonist at A 1 and 2 adenosine receptors but it remains unclear whether mediated by one or both these. As the adenosinergic system rather conserved, we opted to pursue these questions using zebrafish, widely used model organism genetics developmental biology. Zebrafish 1. 2A.1 2A.2 conserve histidine residues TM6 TM7 that are responsible for...
The zebrafish leopard phenotype (leo) displays abnormal pigmentation and shows increased anxiety-like behavior. neurochemical changes associated with this anxious are not known. Here, we demonstrate that leo show behavior in the light/dark box novel tank test. This is rescued by acute treatment a dose of serotonin reuptake inhibitor, fluoxetine, inactive wild-type animals. Moreover, decreased tissue levels serotonin, turnover slightly monoamine oxidase activity. These results suggest...
Widely used in biomedical research, zebrafish (Danio rerio) are steadily gaining popularity as a model organism for studying neurobehavioral phenomena.Here, we focus on to the growing spectrum of behavioral phenotypes and 'bigger' biological problems these models help address.Emphasizing developing potential psychiatry, discuss several questions related this field: Do have 'emotional'-like behaviors?What their neural circuits, biomarkers, ontogenetic origins?And, finally, how can use...
Anxiety is a common symptom associated with high caffeine intake. Although the neurochemical mechanisms of caffeine-induced anxiety remain unclear, there are some evidences suggesting participation oxidative stress. Based on these evidences, current study aimed at evaluating possible protective effect alpha-tocopherol (TPH) against anxiety-like behavior induced by (CAF) in zebrafish. Adult animals were treated CAF (100 mg/kg) or TPH (1 mg/kg)+CAF before behavioral and biochemical...