A5050764385- Crystallization and Solubility Studies
- Asymmetric Synthesis and Catalysis
- X-ray Diffraction in Crystallography
- Asymmetric Hydrogenation and Catalysis
- Radical Photochemical Reactions
- Synthetic Organic Chemistry Methods
- Catalytic Cross-Coupling Reactions
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Crystallography and molecular interactions
- Education, Psychology, and Social Research
- Advanced Photocatalysis Techniques
- Polyoxometalates: Synthesis and Applications
- COVID-19 Clinical Research Studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Cancer Treatment and Pharmacology
- Polymer Surface Interaction Studies
- Drug Solubulity and Delivery Systems
- Machine Learning in Materials Science
- Ammonia Synthesis and Nitrogen Reduction
- Microbial Natural Products and Biosynthesis
- Axial and Atropisomeric Chirality Synthesis
- SARS-CoV-2 and COVID-19 Research
- Sulfur-Based Synthesis Techniques
Columbia University
2021-2025
Sogang University
2022
University of Rostock
2022
Utsunomiya University
2022
Charles University
2012-2021
Institut des Biomolécules Max Mousseron
2016-2018
Université de Montpellier
2016-2018
Centre National de la Recherche Scientifique
2016-2018
École Nationale Supérieure de Chimie de Montpellier
2016-2018
Abstract The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-19 therapy, given its likely druggability and essentiality in the viral maturation replication cycle. Based on conservation of substrate binding pockets across coronaviruses using screening, we identified four structurally distinct lead compounds that inhibit protease. After evaluation their specificity, cellular antiviral potency, metabolic stability, water solubility, prioritized GC376 scaffold as being...
We report the development and characterization of a library Ir(III) photocatalysts capable undergoing spin-forbidden excitation (SFE) under orange light irradiation (595 nm). These catalysts were successfully applied to construction synthetically valuable C(sp2)-C(sp3) bonds inaccessible with existing methods low-energy light-driven dual nickel/photoredox catalysis, demonstrating synthetic utility this photocatalyst family. The are accessing both oxidatively reductively activated coupling...
Abstract The use of low-energy deep-red (DR) and near-infrared (NIR) light to excite chromophores enables catalysis ensue across barriers such as materials tissues. Herein, we report the detailed photophysical characterization a library OsII polypyridyl photosensitizers that absorb light. By tuning ligand scaffold electron density, access range synthetically useful excited state energies redox potentials. 1 Introduction 1.1 Scope 1.2 Measuring Ground-State Redox Potentials 1.3 Photophysical...
Carboxylic acids and their derivatives are powerful building blocks in dual Ir/Ni metallaphotoredox methods of decarboxylative arylation due to abundance as feedstock compounds. However, the library accessible carboxylic is limited by trends radical stability, often necessitating development specific systems for challenging substrates. Herein, we disclose application a new Ir(III) photocatalyst low-energy orange light system with broad applicability activating both native redox-active esters...
Herein we describe a comprehensive study of ligand effects on optoelectronic properties series Ir(III) catalysts which undergo formally spin-forbidden excitation using low-energy light. We demonstrate that electronic and steric tuning several variables can be explained by their impact the HOMO LUMO energies complex. Density functional theory calculations catalysts' adiabatic triplet agree with experimental results to within 0.05 eV average. As many these subtle are independent each other,...
Abstract Monohalo‐ and dihalodiynes efficiently undergo [2+2+2] cyclotrimerization with nitriles in the presence of a catalytic amount ruthenium complex Cp*RuCl(cod) (10 mol%) to afford corresponding halopyridines under ambient conditions good isolated yields (up 90%). The are formed as two separable regioisomers. This is first example direct synthesis from haloalkynes nitriles. magnified image
Regioselective alkylation of γ-cyclodextrin with allyl or propargyl bromide, using optimized reaction conditions, followed by peracetylation the remaining hydroxyl groups and separation isomers resulted in set peracetylated 2I-O-, 3I-O- 6I-O-alkylated cyclodextrins up to 19% yields. Ozonolysis oxidative cleavage derivatives a complete 3I-O-, 6I-O-formylmethyl -carboxymethyl derivatives. All these are useful precursors for further preparation regioselectively monosubstituted γ-cyclodextrin.
Abstract A new method of synthesis an analogue Bolm's 2,2′‐bipyridine ligand based on the catalytic [2+2+2] cyclotrimerization 1‐halodiynes with nitriles was developed. Crucial step whole turned out to be homodimerization a substituted 2‐bromopyridine corresponding bipyridine, that studied and optimized. The newly prepared bipyridine ( S,S )‐ 2 then tested as chiral in metal‐catalyzed enantioselective reactions. Out reactions most promising results were obtained epoxide ring opening (82%...
A general high-yielding method for the preparation of monosubstituted β-cyclodextrin derivatives which have attached a thiol group in position 6 is described. The through linkers different lengths and repeating units (ethylene glycol or methylene). target compounds were characterized by IR, MS NMR spectra. simple their complete conversion to corresponding disulfides as well reduction back thiols presented. Both, are usable well-defined covalent attachment cyclodextrin gold...
Abstract The ring‐opening of epoxides is a synthetically significant process widely applied in all kinds chemistry. Herein, we report the catalytic and highly enantioselective variant this reaction exploiting our recent endeavors to design synthesize chiral bipyridine type ligands. A Sc‐complex with newly developed ligand exhibited high reactivity stereocontrol desymmetrization meso ‐epoxides various alcohols. respective enantiomerically enriched 1,2‐alkoxyalcohols were obtained e.r. values...
Abstract The Ru‐catalyzed reaction of bromodiynes with nitriles (II) and (VII) gives rise to the corresponding bromopyridines, which are obtained as regioisomeric mixtures in most cases.