A5037271494- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- GDF15 and Related Biomarkers
- Biotin and Related Studies
University at Buffalo, State University of New York
2024
Xi’an Children’s Hospital
2013
Abstract Human genetic variation (polymorphisms) in genes coding proteins involved the absorption, distribution, metabolism, and elimination (ADME) of drugs can have a strong effect on drug exposure downstream efficacy safety outcomes. Vamorolone, dissociative steroidal anti‐inflammatory for treating Duchenne muscular dystrophy (DMD), primarily undergoes oxidation by CYP3A4 CYP3A5 glucuronidation UDP‐glucuronosyltransferases. This work assesses pharmacokinetics (PKs) vamorolone sources...
Duchenne muscular dystrophy (DMD), which is caused by mutations in the X-linked dystrophin gene, a severe and progressive neuromuscular disease with no available cure.By integrating 2 microarray datasets from Gene Expression Omnibus, we identified differentially expressed genes stages of DMD systematically explored their potential disease-related mechanisms using network view.Twenty were detected various DMD.According to as its center, none 20 proteins interacts directly.IQ motif-containing...