A5013921595- Photoreceptor and optogenetics research
- Advanced Synthetic Organic Chemistry
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Photochromic and Fluorescence Chemistry
- Molecular Sensors and Ion Detection
Dartmouth College
2024
Southern University of Science and Technology
2020
Pumping ions against a concentration gradient through protein-based transporters is cornerstone of numerous biological processes. Mimicking this function by using artificial receptors remains daunting challenge, mainly because the difficulties in balancing between requirement for high binding affinities and precise on-demand ion capture release properties. We report trimeric hydrazone photoswitch-based receptor that converts light energy into work actively transporting chloride anion...
Abstract Ever since Hirata’s report of yuzurimine in 1966, nearly fifty yuzurimine-type alkaloids have been isolated, which formed the largest subfamily Daphniphyllum alkaloids. Despite extensive synthetic studies towards this synthetically challenging and biologically intriguing family, no total synthesis any has achieved to date. Here, first enantioselective (+)-caldaphnidine J, a highly complex alkaloid, is described. Key transformations approach include regioselective Pd-catalyzed...