A5103185394- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Viral Infections and Vectors
- Neonatal Health and Biochemistry
- Mosquito-borne diseases and control
- Organ Transplantation Techniques and Outcomes
- Congenital Anomalies and Fetal Surgery
- Parasites and Host Interactions
- Neonatal and fetal brain pathology
- Hormonal Regulation and Hypertension
- Global Trade and Competitiveness
- Liver Diseases and Immunity
- Viral gastroenteritis research and epidemiology
- Phenomenology and Existential Philosophy
- Research on Leishmaniasis Studies
- Organic Food and Agriculture
- Economics of Agriculture and Food Markets
- Vascular Tumors and Angiosarcomas
- Psychoanalysis, Philosophy, and Politics
- Biliary and Gastrointestinal Fistulas
Lakeshore Hospital
2024-2025
Sree Sankaracharya University of Sanskrit
2015-2024
University of Bern
2004-2006
St.John's Medical College Hospital
2006
Kuwait University
1992-2000
Amiri Hospital
1992-1996
Hôpital Beaujon
1988-1992
Inserm
1987-1990
Fondation pour la Recherche Médicale
1989
Fondation pour la Recherche Stratégique
1989
Drugs reported to reduce portal pressure through different mechanisms were combined in the hope of either additive hypotensive effects “responders,” or inducing a effect “nonresponders” initial drug. Seven patients with alcoholic cirrhosis received verapamil, 10 mg i.v., and, 60 min later, ketanserin, 5 i.v. Verapamil decreased heart rate and increased free hepatic venous but had no on gradient azygos blood flow. When ketanserin significantly diminished wedged gradient. Ten other...
Since the Asian Pacific Association for Study of Liver (APASL) published guidelines on non-cirrhotic portal fibrosis/idiopathic hypertension in 2007, there has been a surge new information, especially with introduction term porto-sinusoidal vascular disorder (PSVD). Non-cirrhotic intra-hepatic causes include disorders clearly identifiable etiology, such as schistosomiasis, well an unclear etiology fibrosis (NCPF), also termed idiopathic (IPH). This entity is being increasingly recognized...
Abstract: Response to treatment with alpha interferon or without concomitant ribavirin varies according the viral genotype in patients chronic hepatitis C. Aim: This study was undertaken order determine response of 4 C and combination compared alone cirrhosis. Methods: Fifty‐two were given at a dose 5 million units, 3 times week another 60 administered combined ribavarin (1000–1200 mg/day) for 24 weeks. Sustained biochemical defined as normal ALT, 6 months after end therapy. virologic...
The acute effects of nifedipine, 10 mg administered sublingually, were studied in patients with alcoholic cirrhosis. Nifedipine significantly increased cardiac output and reduced systemic vascular resistance. also the hepatic venous pressure gradient by 15% (P < 0.01). Hepatic blood flow azygos did not change significantly. It is suggested that nifedipine increases portal thus may be deleterious to hypertension. Clinical Pharmacology Therapeutics (1987) 42, 295–298; doi:10.1038/clpt.1987.150
Abstract: Background: The role of endothelial nitric oxide synthase 3 (NOS‐3) in the hyperdynamic circulation associated with cirrhosis is established but not that neuronal (NOS‐1) isoform. We therefore investigated aortic NOS‐1 levels NOS‐3 knock‐out (KO) and wildtype (WT) mice hepatic arteries patients. Methods: Mice rendered cirrhotic by bile duct ligation (BDL) were compared sham‐operated controls. Hepatic patients collected during liver transplantation; donor vessels served as mRNA...
To determine the reproducibility of splanchnic blood flow measurements by microsphere method in rats with portal hypertension and effects laparotomy vein cannulation, eight groups 10 were studied. Cardiac output regional flows measured twice, min apart, pentobarbital anesthetized or awake, sham-operated vein-ligated rats, without cannulation. Variability between two successive was not affected different territory other organs. Laparotomy cannulation had no significant effect rats. In awake...
The effects of increasing doses propranolol were studied in awake portal hypertensive rats order to elucidate the relative β-blocker on systemic and splanchnic circulation. Hemodynamic responses 0.1, 0.2 0.4 mg per min infusions compared with placebo hypertension due vein stenosis. Heart rate significantly progressively decreased from 356 ± 13 293 10 beats (mean S.E.). Cardiac output 54 3 42 ml 100 gm body weight at highest dose. Significant decrease tributary blood flow 27 1 18 min, dose,...
53 adult patients with acute hepatitis caused by E virus were identified the presence of IgM antibody to virus, and followed for 12 months evaluate kinetics anti-HEV antibodies. All but 1 female Kuwaiti patient expatriate workers from Indian subcontinent, temporarily working in Kuwait. Follow-up samples obtained at 1, 3, 6 evalutated IgG antibodies virus. IgM-class detectable 12/27 (44%) month, 0/26 3 months, 0/8 0/6 months. 46/47 (98%) onset, 26/27 (96%) 26/29 (90%) 16/16 (100%) 8/8...
Abstract The essay questions the predominant perception of human thinking as a gender-neutral enterprise. It holds that sexual difference is deeply engrained in language and thinking, regardless biological identities those who express thoughts. critiques traditional thought for superficially linking meaning sexuality with gender. opposes characterisation masculine man’s feminine woman’s. Masculine expressions can sometimes happen from women writers, male thinkers produce writings. Biological...
Abstract: Background/Aims: It is postulated that nitric oxide (NO) responsible for the hyperdynamic circulation of portal hypertension. Therefore, we investigated induction fibrosis and in endothelial NO synthase knock‐out (KO) mice. Methods: Fibrosis was induced by bile duct ligation. Hemodynamic studies were performed after vein All wild‐type (WT) KO Results: Three to 4 weeks ligation (BDL), both WT groups had similar degrees hypertension, 12 (9–14) 11(8–15) mmHg, median (range), liver...
In animals, there may exist a hyperemic response in the portal circulation during intravenous administration of hypertonic glucose, but hemodynamic this kind has never been described man. This study was designed to evaluate if hyperglycemia itself could induce systemic or splanchnic changes patients with cirrhosis. Sixteen cirrhosis were studied before and i.v. infusions (900 mOsmoles per liter) glucose (n = 8), mannitol 4) saline at 2 ml min. group receiving significant increases hepatic...
ABSTRACT In order to study the acute effects of pharmacological agents on vascular resistance portal‐systemic collaterals, a model total portal vein occlusion with 100% shunts was developed in conscious rat. The haemodynamic several vaso‐active substances were evaluated this and compared those obtained after saline administration. Prazosin (0.5 mg), an α 1 ‐adrenergic antagonist, significantly reduced mean arterial pressure by 29%, from 13.8 ± 1.0 (mean s.e.m.) 10.1 0.4 mmHg tributary blood...
Abstract Fifty‐seven adult patients with acute hepatitis and 34 comparison without liver disease were evaluated using a newly developed Western blot assay for IgM antibody to E virus. The mean age of was 32 years (range, 18‐55 years); 88% male. Among hepatitis, A (anti‐HAV positive) diagnosed in two (4%), B (anti‐HBc three (5%), (anti‐HEV (60%). One patient had CMV IgM, another EBV 16 others (28%) negative all serologic markers viral hepatitis. No or none the anti‐HEV IgM. All but one case...
1. In order to study the acute effects of blood volume changes on vascular resistance portal-systemic collaterals (collateral resistance), a model total portal vein occlusion with 100% shunts was developed in rat. this model, we determined haemodynamic haemorrhage (1.8 ml/100 g body weight) or intravenous infusion expander weight). Cardiac output and regional flows were measured by radioactive microsphere method. 2. Haemorrhage significantly reduced arterial pressure from 108 ± 4 92 mmHg...