A5009841709- Cystic Fibrosis Research Advances
- Immunodeficiency and Autoimmune Disorders
- Genomics and Rare Diseases
- Air Quality and Health Impacts
South African Tuberculosis Vaccine Initiative
2021
Stellenbosch University
2021
South African Medical Research Council
2021
Primary immunodeficiency disorders (PIDs) are inborn errors of immunity (IEI) that cause immune system impairment. To date, more than 400 single-gene IEI have been well defined. The advent next generation sequencing (NGS) technologies has improved clinical diagnosis and allowed for discovery novel genes variants associated with IEI. Molecular provides clear benefits patients by altering management, enabling access to certain treatments facilitates genetic counselling. Here we report on an...
The influence of smoke-derived or air pollution-derived cytoplasmic particulate matter (PM) can be detrimental and lead to failed lung immunity. We investigated mycobacterial uptake, intracellular replication, soluble immune-mediator responses human bronchoalveolar lavage cells (BALCs) loaded with/without PM, infection with strains. observed that only BALCs containing PM display an ex vivo phenotypic profile dominated by spontaneous interleukin (IL)-10 production. PM-loaded retained the...