A5020717061- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Crystallography and molecular interactions
- Neonatal Health and Biochemistry
- Hemoglobin structure and function
- Neurobiology and Insect Physiology Research
- Atmospheric chemistry and aerosols
- Indoor Air Quality and Microbial Exposure
- Heme Oxygenase-1 and Carbon Monoxide
- Catalysis and Oxidation Reactions
- Oxidative Organic Chemistry Reactions
- Chemical synthesis and alkaloids
- Zebrafish Biomedical Research Applications
- Molecular Sensors and Ion Detection
- Circadian rhythm and melatonin
- Lichen and fungal ecology
- Axial and Atropisomeric Chirality Synthesis
- Sulfur Compounds in Biology
- Atmospheric Ozone and Climate
- Retinal Development and Disorders
- Synthesis and Characterization of Pyrroles
- Porphyrin and Phthalocyanine Chemistry
- Bioactive Compounds and Antitumor Agents
- Alkaloids: synthesis and pharmacology
California Institute of Technology
2023-2024
University of Denver
2018-2022
Carbon monoxide (CO) is an emerging gasotransmitter and reactive carbon species with broad anti-inflammatory, cytoprotective, neurotransmitter functions along therapeutic potential for the treatment of cardiovascular diseases. The study CO chemistry in biology medicine relative to other prominent gasotransmitters such as NO H2S remains challenging, large part due limitations available tools direct visualization this transient freely diffusing small molecule complex living systems. Here we...
Secondary organic aerosol (SOA) is ubiquitous in the atmosphere and plays a pivotal role climate, air quality, health. The production of low-volatility dimeric compounds through accretion reactions key aspect SOA formation. However, despite extensive study, structures thus formation mechanisms dimers remain largely uncharacterized. In this work, we elucidate several major dimer esters from ozonolysis α-pinene β-pinene-substantial global sources-through independent synthesis authentic...
Aleutianamine is a recently isolated pyrroloiminoquinone natural product that displays potent and selective biological activity toward human pancreatic cancer cells with an IC50 of 25 nM against PANC-1, making it potential candidate for therapeutic development. We report synthetic approach to aleutianamine wherein the unique [3.3.1] ring system tertiary sulfide this alkaloid were constructed via novel palladium-catalyzed dearomative thiophene functionalization. Other highlights synthesis...
In this work, we find significant branching to an accretion product in the self-reaction of ethene-derived hydroxy peroxy radicals.
Dopaminergic neurons innervate extensive areas of the brain and release dopamine (DA) onto a wide range target neurons. However, DA is also precisely regulated. In Drosophila melanogaster explant preparations, released specifically α3/α′3 compartments mushroom body (MB) that have been coincidentally activated by cholinergic glutamatergic inputs. The mechanism for this precise has unclear. Here we found MB generate carbon monoxide (CO), which functions as retrograde signal evoking local from...
ABSTRACT: Pyrroloiminoquinone alkaloids are a large class of natural products that display wide range biologi-cal activities. Synthetic approaches to these typically rely on common late-stage C10-oxygenated pyrroloiminoquinone intermediate, but strategies often lead lengthy synthetic sequences not ame-nable divergent syntheses. We devised an alternative approach aimed at the early introduction C10 nitro-gen, which we hypothesized would enable diversification. This strategy hinged upon...
Pyrroloiminoquinone alkaloids are a large class of natural products that display wide range biological activities. Synthetic approaches to these typically rely on common late-stage C10-oxygenated pyrroloiminoquinone intermediate, but strategies often lead lengthy synthetic sequences not amenable divergent syntheses. We devised an alternative approach aimed at the early introduction C10 nitrogen, which we hypothesized would enable diversification. This strategy hinged upon...
ABSTRACT: Aleutianamine is a recently isolated pyrroloiminoquinone natural product that displays potent and selective biological activity toward human pancreatic cancer cells with an IC50 = 25 nM against PANC-1, making it potential candi-date for therapeutic development. We report synthetic approach to aleutianamine wherein the unique [3.3.1] ring system tertiary sulfide of this alkaloid were constructed via novel palladium-catalyzed dearomative thiophene functionalization. Other highlights...
Most methods of classifying airborne pollen are labor-intensive and prohibitively expensive, which limits the scales at predictions about ambient allergy conditions can be provided. A spectroscopic technique was developed toward inexpensively providing information important groups. The uses a single-particle fluorescence spectrometer to analyze super-micron atmospheric bioparticles, e.g., fungal spores, collected onto substrate. Thirty-four species were sampled from plants Denver Botanic...
Carbon monoxide (CO) is an emerging gasotransmitter and reactive carbon species with broad anti-inflammatory, cytoprotective, neurotransmitter functions along therapeutic potential for the treatment of cardiovascular diseases. The study CO chemistry in biology medicine relative to other prominent gasotransmitters such as NO H2S remains challenging, large part due limitations available tools direct visualization this transient freely diffusing small molecule complex living systems. Here we...
ABSTRACT Dopaminergic neurons innervate extensive areas of the brain and release dopamine (DA) onto a wide range target neurons. However, DA is also precisely regulated, in Drosophila, released specifically mushroom body (MB) neurons, which have been coincidentally activated by cholinergic glutamatergic inputs. The mechanism for this precise has unclear. Here we found that MB generate carbon monoxide (CO) functions as retrograde signal evoking local from presynaptic terminals. CO production...
Carbon monoxide (CO) is an emerging gasotransmitter and reactive carbon species with broad anti-inflammatory, cytoprotective, neurotransmitter functions along therapeutic potential for the treatment of cardiovascular diseases. The study CO chemistry in biology medicine relative to other prominent gasotransmitters such as NO H2S remains challenging, large part due limitations available tools direct visualization this transient freely diffusing small molecule complex living systems. Here we...