A5024282022- Cancer Treatment and Pharmacology
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Childhood Cancer Survivors' Quality of Life
- Genetic and Kidney Cyst Diseases
- Hedgehog Signaling Pathway Studies
- Innovations in Medical Education
- Protist diversity and phylogeny
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Cancer survivorship and care
- Multiple and Secondary Primary Cancers
- Medical Education and Admissions
- Mentoring and Academic Development
- Sarcoma Diagnosis and Treatment
Medical College of Wisconsin
2020-2023
Mayo Clinic
2018
WinnMed
2018
Tubulin polyglutamylation is a predominant axonemal post-translational modification. However, if and how axoneme essential for primary cilia contribute to ciliopathies are unknown. Here, we report that Joubert syndrome protein ARL13B controls polyglutamylation, which marginally required stability but signaling. interacts with RAB11 effector FIP5 promote import of glutamylase TTLL5 TTLL6. Hypoglutamylation caused by deficient ARL13B-RAB11-FIP5 trafficking pathway shows no effect on...
Background: The Medical College Admission Test (MCAT) is a standardized exam taken by prospective medical students. MCAT critical for success in most of the US and parts Canada, such pressures may enhance test anxiety. For students from Underrepresented Medicine (URM) backgrounds, this often compounded being first their family to take MCAT. Methods: We conducted literature review interventions on test-related Based our findings, we elected establish pilot near-peer coaching (NPC) program URM...
e18795 Background: Sarcomas are a type of cancer that have been historically difficult to treat given their rarity, numerous subtypes, and variable response treatment. Doxorubicin is the most used first-line chemotherapy in metastatic sarcoma; pegylated liposomal doxorubicin (PLD) has explored as potentially better tolerated alternative free doxorubicin, with less myelosuppression, alopecia, cardiotoxicity. In this work, we examine efficacy real-world challenges using PLD treatment for...
e20558 Background: Multiple Myeloma (MM) is the second most common hematological malignancy in U.S., with higher rates observed older adults and African Americans (AA). Given treatment advances, individuals survive at least 5-10 years, making symptom management important. Many survivors struggle pain, fatigue limited physical function, all of which may be improved through lifestyle changes. Due to concerns about safety patient interest, few efforts have considered such interventions. We...
Abstract Purpose: Multiple Myeloma (MM) is the second most common hematologic malignancy in U.S., with higher rates observed older adults and African Americans (AA). Survivors experience fatigue, bone pain, reduced functioning. The high incidence of obesity among MM survivors may be partly responsible. These factors highlight value developing lifestyle interventions to meet needs this diverse group. This study aims inform development a program tailored community. Methods: who were ≥100 days...