A5074422089- Autophagy in Disease and Therapy
- HIV Research and Treatment
- Mosquito-borne diseases and control
- Calcium signaling and nucleotide metabolism
- HIV/AIDS drug development and treatment
- interferon and immune responses
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Bacterial biofilms and quorum sensing
- Toxoplasma gondii Research Studies
- Vibrio bacteria research studies
- RNA modifications and cancer
- Lysosomal Storage Disorders Research
- Cytomegalovirus and herpesvirus research
- Lung Cancer Diagnosis and Treatment
- Cannabis and Cannabinoid Research
Umeå University
2021-2023
Instituto de Investigación Biosanitaria de Granada
2023
Universidad de Granada
2023
University of Rochester Medical Center
2021
Texas Tech University
2018-2020
Abstract Lysosomal membrane damage represents a threat to cell viability. As such, cells have evolved sophisticated mechanisms maintain lysosomal integrity. Small lesions are detected and repaired by the endosomal sorting complex required for transport (ESCRT) machinery while more extensively damaged lysosomes cleared galectin‐dependent selective macroautophagic pathway (lysophagy). In this study, we identify novel role autophagosome‐lysosome tethering factor, TECPR1, in repair. promotes...
Macroautophagy/autophagy is an auto-digestive pro-survival pathway activated in response to stress target cargo for lysosomal degradation. In recent years, autophagy has become prominent as innate antiviral defense mechanism through multiple processes, such targeting virions and viral components elimination. These exciting findings have encouraged studies on the ability of restrict HIV. However, role HIV infection remains unclear. Whereas some reports indicate that detrimental HIV, others...
Pore-forming toxins (PFTs) are important virulence factors produced by many pathogenic bacteria. Here, we show that the Vibrio cholerae toxin MakA is a novel cholesterol-binding PFT induces non-canonical autophagy in pH-dependent manner. specifically binds to cholesterol on membrane at pH < 7. Cholesterol-binding leads oligomerization of and pore formation 5.5. Unlike other cholesterol-dependent cytolysins (CDCs) which bind through conserved motif (Thr-Leu pair), contains an Ile-Ile pair...
Ubiquitination is a process that acts upon every step of the HIV replication cycle. The activity, subcellular localization, and stability dependency factors as well negative modulators can be affected by ubiquitination. These modifications consequently have an impact on progression outcome infection. Additionally, recent findings suggest new roles for ubiquitination in interplay between cellular environment, specifically interactions HIV, autophagy apoptosis. On one hand, defense mechanism...
Breast cancer-associated gene 2 (BCA2) is an E3 ubiquitin and SUMO ligase with antiviral properties against HIV. Specifically, BCA2 (i) enhances the restriction imposed by BST2/Tetherin, impeding viral release; (ii) promotes ubiquitination degradation of HIV protein Gag, limiting virion production; (iii) down-regulates NF-κB, which necessary for RNA synthesis; (iv) activates innate transcription factor IRF1. Due to its properties, ectopic expression in infected cells represents a promising...
Autophagy plays an important role as a cellular defense mechanism against intracellular pathogens, like viruses. Specifically, autophagy orchestrates the recruitment of specialized cargo, including viral components needed for replication, lysosomal degradation. In addition to this primary role, cleavage structures facilitates their association with pattern recognition receptors and MHC-I/II complexes, which assists in modulation innate adaptive immune responses these pathogens. Importantly,...