A5026834413- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Catalytic C–H Functionalization Methods
- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- Cyclopropane Reaction Mechanisms
- Plant nutrient uptake and metabolism
- Crystal structures of chemical compounds
- Luminescence and Fluorescent Materials
- Asymmetric Synthesis and Catalysis
- Advanced Data Storage Technologies
- Molecular Junctions and Nanostructures
- Catalytic Cross-Coupling Reactions
- Plant Micronutrient Interactions and Effects
- Legume Nitrogen Fixing Symbiosis
- Porphyrin and Phthalocyanine Chemistry
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Oxidative Organic Chemistry Reactions
- Polyoxometalates: Synthesis and Applications
- Plant Stress Responses and Tolerance
- Organometallic Compounds Synthesis and Characterization
- Covalent Organic Framework Applications
Chinese Academy of Sciences
2014-2025
Fujian Institute of Research on the Structure of Matter
2014-2025
Nanning Normal University
2020-2025
University of Chinese Academy of Sciences
2014-2025
Zhejiang University of Technology
2010-2025
Jilin University
2014-2024
Central China Normal University
2024
Northwest A&F University
2024
Robert Bosch (Germany)
2024
Fuzhou University
2016-2023
Monofunctional platinum(II) complexes of general formula cis -[Pt(NH 3 ) 2 ( N -heterocycle)Cl]Cl bind DNA at a single site, inducing little distortion in the double helix. Despite this behavior, these compounds display significant antitumor properties, with different spectrum activity than that classic bifunctional cross-linking agents like cisplatin. To discover most potent monofunctional compounds, -heterocycle was systematically varied to generate small library new guidance from X-ray...
Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAFV600E-melanoma, autophagy by BRAF inhibitor (BRAFi), as part of a transcriptional program coordinating lysosome biogenesis/function, mediated the TFEB transcription factor. phosphorylated thus inactivated BRAFV600E via downstream ERK independently mTORC1. BRAFi disrupts phosphorylation, allowing nuclear translocation, which...
The difference in the hydrogen bonding interactions originating from different organic cations brings photoluminescence with distinct quantum yields.
Summary Nitrogen (N) is one of the key essential macronutrients that affects rice growth and yield. Inorganic N fertilizers are excessively used to boost yield generate serious collateral environmental pollution. Therefore, improving crop use efficiency (NUE) highly desirable has been a major endeavour in improvement. However, only few regulators have identified can be improve NUE date. Here we show NIN‐like protein 4 (OsNLP4) significantly improves Field trials consistently showed loss‐of‐...
We report two platinum(IV) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays activity both cisplatin and α-TOS in cancer cells, causing damage to DNA mitochondria simultaneously. Accordingly, it serves as promising dual-targeting anticancer agent.
FJSM-InMOF with facile synthesis showed remarkable Cs<sup>+</sup> and Sr<sup>2+</sup> ion-exchange performance an unprecedented structural-transformation to illuminate the capture mechanism.
The Co(III)-catalyzed redox-neutral annulation of benzamides and acrylamides with vinylene carbonate for the synthesis isoquinolinones pyridinones has been developed. This protocol employing inexpensive Co(III) as catalyst tolerated diverse functional groups substitution patterns, affording target products good to excellent yields. synthetic utility this transformation was demonstrated by a three-step gusanlung D, 8-oxopseudopalmatine, oxopalmatine.
Abstract Herein, a new mechanism, namely, crystalline phase recognition (CPR), is proposed for the single‐crystal‐to‐single‐crystal (SCSC) transition of metal halides. Chiral β‐[Bmmim] 2 SbCl 5 (Bmmim=1‐butyl‐2,3‐methylimidazolium) can recognize achiral α‐[Bmmim] on basis key–lock feature through intercontact their single crystals, resulting in domino (DPT). The concomitant photoluminescence (PL) switching enables observation DPT situ. liquid eutectic interface, stress–strain transfer, and...
Abstract Nitrogen (N) is an essential macronutrient for crop growth and yield. Improving the N use efficiency (NUE) of crops important to agriculture. However, molecular mechanisms underlying NUE regulation remain largely elusive. Here we report that OsNLP3 (NIN‐like protein 3) regulates grain yield in rice under sufficient conditions. transcript level significantly induced by starvation its nucleocytosolic shuttling specifically regulated nitrate. Loss‐of‐function reduces plant growth,...
Traditional hydrogel sensors containing MXenes as a conductive substrate will inevitably face the problem of excessive stacking MXene nanosheets, which limits electron transport, thus reducing conductivity and sensitivity. Moreover, existing hydrogels generally exhibit poor mechanical properties fragility. In addition, it is necessary to prepare degradable electronic skins for environmental pollution recycling energy materials─MXene. How find balance between degradation challenge. this work,...
[reaction: see text]. The copper acetate mediated intramolecular O-arylation of phenols with phenylboronic acid pseudopeptides is the key step in preparation macrocyclic biphenyl ether hydroxamic inhibitors collagenase 1 and gelatinases A B. macrocyclization was found to be mild tolerant common chemical functionality. This methodology should provide a general route ethers.
Pt(IV) anticancer compounds typically operate as prodrugs that are reduced in the hypoxic environment of cancer cells, losing two axial ligands process to generate active Pt(II) species. Here we report synthesis fluorescent cisplatin order image and evaluate reduction simulated real biological environments. Treatment complexes dissolved PBS buffer with reducing agents encountered glutathione or ascorbate, afforded a 3- 5-fold fluorescence turn-on owing loss their fluorescein-based ligands,...
Macroautophagy/autophagy is an auto-digestive pro-survival pathway activated in response to stress target cargo for lysosomal degradation. In recent years, autophagy has become prominent as innate antiviral defense mechanism through multiple processes, such targeting virions and viral components elimination. These exciting findings have encouraged studies on the ability of restrict HIV. However, role HIV infection remains unclear. Whereas some reports indicate that detrimental HIV, others...
Salt stress is a major constraint on plant growth and yield. Nitrogen (N) fertilizers are known to alleviate salt stress. However, the underlying molecular mechanisms remain unclear. Here, we show that nitrate-dependent tolerance mediated by OsMADS27 in rice. The expression of specifically induced nitrate. salt-inducible also nitrate dependent. knockout mutants more sensitive than wild type, whereas overexpression lines tolerant. Transcriptomic analyses revealed upregulates number...
Power transformers are the vital and expensive components of power system. Timely identifying diagnosing transformer faults is critical to maintaining stability grid. As a sensitive economical tool, frequency response analysis (FRA) method has been widely employed detect winding faults. However, it still challenge accurately identify fault types degrees only by FRA method. In this article, new diagnosis that combines with kernel-based extreme learning machine (KELM) optimized seagull...
Two new crystalline thioarsenate compounds, formulated as [pipH2][Mn2As2S6] (1) and [TMDPH2][As4S6] (2) (pip = piperazine, TMDP 1,3-bis(4-piperidyl)propane), have been surfactant–thermally synthesized with the utilization of octylamine PEG-400 solvents. The crystal structure 1 features [Mn2As2S6]n2n– anionic layers which are separated by doubly protonated [pipH2]2+ cations, while that compound 2 is made discrete [As4S6]2– clusters [TMDPH2]2+ cations. Both compounds were characterized powder...
Phosphorescence and X-ray scintillation are achieved for chlorobismuthate hybrids incorporating ionic liquid cations.
A series of hybrid tellurium chlorides based on ionic liquids (ILs), namely, α-[Bmim]2TeCl6 (1, Bmim = 1-butyl-3-methyl imidazolium), β-[Bmim]2TeCl6 (2), [HOOCMim]2TeCl6 (3, HOOCMim 1-carboxymethyl-3-methyl [Bzmim]2TeCl6 (4, Bzmim 1-benzyl-3-methyl [EPy]2TeCl6 (5, EPy 1-ethylpyridinium), [Bmmim]2TeCl6 (6, Bmmim 1-butyl-2,3-dimethyl have been synthesized and characterized. Different kinds supramolecular networks obtained via self-assemblies isolated [TeCl6]2– anions various liquid cations....
Understanding common and unique mechanisms driving oncogenic processes in human tumors is indispensable to develop efficient therapies. Recent studies have proposed Twinfilin Actin Binding Protein 1 (TWF1) as a putative driver gene lung cancer, pancreatic cancer breast however systematic pan-cancer analysis has not been carried out.Here, we set out explore the role of TWF1 33 tumor types using TCGA (The Cancer Genome Atlas), GEO (Gene Expression Omnibus) dataset, Human Atlas (HPA), several...
New flex-activated mechanophore allows for mechanical damage in polymers using a simple household CO detectors, addition to the formation of an extended and fluorescent π system.
A Co(III)-catalyzed vinylene transfer reaction enabled by carboxylic acid is presented. This redox-neutral transformation tolerates various functional groups, including free hydroxyl and features practicality. Five-step routes based on the Heck annulation have been devised to total synthesis of 8-oxodehydrodiscretamine 2-demethyl-oxypalmatine without protection functionality.