A5024333915- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- RNA Research and Splicing
- Bacterial Genetics and Biotechnology
- Eosinophilic Esophagitis
- Animal Disease Management and Epidemiology
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Inflammatory Bowel Disease
- DNA Repair Mechanisms
- ATP Synthase and ATPases Research
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Cancer therapeutics and mechanisms
- Gamma-ray bursts and supernovae
- Herpesvirus Infections and Treatments
- Helicobacter pylori-related gastroenterology studies
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Trace Elements in Health
- Rabies epidemiology and control
Raigmore Hospital
2023
Wrightington, Wigan and Leigh NHS Foundation Trust
2017-2021
Fordham University
2015-2021
Royal Aberdeen Children's Hospital
2021
Pennine Care NHS Foundation Trust
2021
University of Maryland, Baltimore
2020
Wrightington Hospital
2017
University of California, Berkeley
2017
Southern California Coastal Water Research Project
2017
Kettering University
2006-2016
A total of 8268 dogs were surveyed in 11 veterinary practices the United Kingdom during a period six months 1983. The primary purpose survey was to assess level obesity on five point scale with properly identified criteria. Information clinical condition each dog also recorded as well proportions food types fed, particulars breed, sex, age, sexual status and dog's name. Results showed that 21.4 per cent judged be obese 2.9 gross; 1.9 thin, 13.5 lean 60.3 optimum. Labradors found most likely...
BtuF is the periplasmic binding protein (PBP) for vitamin B12 transporter BtuCD, a member of ATP-binding cassette (ABC) superfamily transmembrane pumps. We have determined crystal structures Escherichia coli in apo state at 3.0 A resolution and with bound 2.0 resolution. The structure similar to that FhuD TroA PBPs composed two alpha/beta domains linked by rigid alpha-helix. "base-on" or conformation wide acidic cleft located between these domains. C-terminal domain shares structural...
Childhood-onset mitochondrial encephalomyopathies are usually severe, relentlessly progressive conditions that have a fatal outcome. However, puzzling infantile disorder, long known as 'benign cytochrome c oxidase deficiency myopathy' is an exception because it shows spontaneous recovery if infants survive the first months of life. Current investigations cannot distinguish those with good prognosis from terminal disease, making very difficult to decide when continue intensive supportive...
Rainstorms increase levels of fecal indicator bacteria in urban coastal waters, but it is unknown whether exposure to seawater after rainstorms increases rates acute illness. Our objective was provide the first estimates illness during both dry- and wet-weather periods determine relationship between among surfers, a population with high potential for rain. We enrolled 654 surfers San Diego, California, followed them longitudinally 2013-2014 2014-2015 winters (33,377 days observation, 10,081...
Details of admissions to a dedicated district poisons treatment unit in South Glamorgan were analysed assess changes self-poisoning patterns between 1987-1988 and 1992-1993. Self-poisoning rates increased both men women, with male showing relatively larger increase, resulting fall female ratio for person-based from 1.33:1 1.13:1. The highest age-specific period found 15-19-year-old females. Paracetamol was the most commonly ingested poison 1992-1993, 43.4% episodes involving its use,...
To determine whether intravenous 3.5 per cent amino acid solution enhanced the rate of albumin synthesis in postoperative patients, we measured by (14C) carbonate technic 10 patients on fourth day after elective gastrointestinal-tract operations. Five were randomized to receive a essential and non-essential acids, five 5 glucose. A mean (+/-S.E.M.) 75.0+/-2.0 acids or 111.0+/-12.4 glucose was given. In group 237+/-24 mg kilogram day, comparison 157+/-23 (P less than 0.05). The infused...
<b>Aim:</b> To study alterations in choroidal blood flow (CBF) the foveal region after panretinal photocoagulation (PRP) patients with severe proliferative diabetic retinopathy. <b>Methods:</b> Seventeen eyes of 17 non-proliferative retinopathy (PDR) or non-high-risk PDR and no macular edema before PRP were included. All underwent four sessions scatter PRP. We measured velocity (CBVel), volume (CBVol), CBF 1 month using a laser Doppler flowmetry. <b>Results:</b> Macular did not develop any...
Mutations in several mitochondrial DNA and nuclear genes involved protein synthesis have recently been reported combined respiratory chain deficiency, indicating a generalized defect translation. However, the number of patients with pathogenic mutations is small, implying that defects translation are either underdiagnosed or intrauterine lethal. No comprehensive studies on large cohorts deficiency addressing role affecting to date. We investigated cohort 52 without causative mutations,...
Real-life data on vedolizumab effectiveness in inflammatory bowel disease (IBD) are still emerging. Data the comparative safety of gut selective profile particular interest.To assess clinical outcome and IBD patients treated with vedolizumab.We retrospectively collected at eight UK hospitals (August 2014-January 2018). Clinical response remission 14 52 weeks evaluated through Physician Global Assessment (PGA) adverse events were recorded. Possible predictors examined.Two hundred three (mean...
The SecA ATPase drives the processive translocation of N terminus secreted proteins through cytoplasmic membrane in eubacteria via cycles binding and release from SecYEG translocon coupled to ATP turnover. forms a physiological dimer with dissociation constant that has previously been shown vary temperature ionic strength. We now present data showing oligomeric state solution is altered by ligands it interacts during protein translocation. Analytical ultracentrifugation, chemical...
One hundred and one patients were studied in a double-blind controlled trial to assess the role of oral cimetidine preventing continuation or recurrence acute upper gastrointestinal haemorrhage from various sources, chiefly peptic ulcer. The dose was 800 mg on entering study followed by 400 six hourly. source bleeding identified endoscopically 96% patients, ulcer comprising 70%. Bleeding continued recurred 11 51 (21.5%) 12 50 (24%) placebo. Analysis effect according age severity showed no...
Childhood-onset mitochondrial encephalomyopathies are severe, relentlessly progressive conditions. However, reversible infantile respiratory chain deficiency (RIRCD), due to a homoplasmic mt-tRNAGlu mutation, and hepatopathy, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase (TRMU) deficiency, stand out by showing spontaneous recovery, provide the key treatments of potential broader relevance. Modification is possible functional link between these two conditions, since TRMU...
Summary Background The optimal choice of biological agents after failure anti‐tumour‐necrosis‐factor‐(TNF)α agent in Crohn’s disease (CD) is yet to be defined. Aims To assess the effectiveness and safety ustekinumab compared vedolizumab as second‐line treatment CD patients who failed anti‐TNFα therapy. Methods Retrospective analysis clinical response remission at 14 52 weeks by physician global assessment (PGA). A propensity score‐matched with a cohort treated was performed. Results Of 282...
CRISPRs (clustered regularly interspaced short palindromic repeats) provide bacteria and archaea with RNA-guided acquired immunity to invasive DNAs. CRISPR-associated (Cas) proteins carry out the immune effector functions. Cas2 is a universal component of CRISPR system. Here, 1.35 Å resolution crystal structure from bacterium Desulfovibrio vulgaris (DvuCas2) reported. DvuCas2 homodimer, each protomer consisting an N-terminal βαββαβ ferredoxin fold (amino acids 1-78) which appended C-terminal...
Mutations of mitochondrial DNA are linked to many human diseases.Despite the identification a large number variants in mitochondrially encoded rRNA (mt-rRNA) genes, evidence supporting their pathogenicity is, at best, circumstantial.Establishing these variations is major diagnostic importance.Here, we aim estimate disruptive effect mt-rRNA on function ribosome.In absence direct biochemical methods study variations, relied universal conservation fold infer potential.Our method, named...