A5100349282- Burn Injury Management and Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Plant Gene Expression Analysis
- Escherichia coli research studies
- Inhalation and Respiratory Drug Delivery
- Virology and Viral Diseases
- Immunotherapy and Immune Responses
- Parasitic Infections and Diagnostics
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Advanced Drug Delivery Systems
- Poxvirus research and outbreaks
- Wound Healing and Treatments
- Helicobacter pylori-related gastroenterology studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Microbial Metabolism and Applications
- Phytochemistry and biological activities of Ficus species
- Liver Disease Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Salmonella and Campylobacter epidemiology
- Synthesis and Biological Evaluation
- Herpesvirus Infections and Treatments
WuXi AppTec (China)
2017-2023
Anyang Institute of Technology
2019
Jilin Medical University
2014
Peking University
2003-2005
Beijing Jishuitan Hospital
2003-2005
Beijing Tian Tan Hospital
1985
Bicyclic azetidines potently inhibit Cryptosporidium in vivo by targeting phenylalanyl-tRNA synthetase.
Pathogenic variants in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified that increase risk for developing Parkinson's disease a dominantly inherited fashion. These pathogenic variants, of which G2019S is most common, cause abnormally high activity, and compounds inhibit this activity are being pursued as potentially disease-modifying therapeutics. Because LRRK2 regulates important cellular processes, inhibitors can selectively target variant while sparing normal could offer...
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat antibiotic-resistant infections, in part due to emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options currently exist, many which result disease relapse. We sought identify molecules specifically targeting C. high-throughput screens our diversity-oriented synthesis compound collection. identified two scaffolds with apparently novel mechanisms action that...
Abstract Pseudomonas aeruginosa poses a major threat to human health and the mink industry. Thus, development of vaccines that elicit robust humoral cellular immunity against P. is greatly needed. In this study, recombinant attenuated Salmonella vaccine (RASV) expresses outer membrane proteins fusion OprF 190–342 ‐OprI 21–83 (F1I2) from was constructed potency candidate assessed by measuring F1I2‐specific immune responses upon vaccination through s.c. or oral routes. S.C. administration...