A5102787050- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Immune Response and Inflammation
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Telomeres, Telomerase, and Senescence
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Immune responses and vaccinations
- Cellular Mechanics and Interactions
- Psoriasis: Treatment and Pathogenesis
- Genetics, Aging, and Longevity in Model Organisms
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
Jinzhou Medical University
2019-2024
Human regulatory T (Treg) cells play a central role in controlling allergic inflammation the airways. A reduced number of peripheral Treg and decreased suppressive function have been previously reported pathogenesis asthma. However, characteristic specific cell subsets their mechanisms asthma remain unclear. In this study, we examined proportion different both healthy subjects patients with using flow cytometry single-cell RNA sequencing. The migration was compared sorting Transwell...
Background Telocytes, recently recognized as interstitial cells with a diverse range of potential functions, have attracted considerable attention for their involvement in tumorigenesis. Nevertheless, owing to certain challenges the isolation and cultivation telocytes, research on telocytes has advanced rather slowly. Therefore, it is imperative study role mechanisms tumors. Methods We improved separation method successfully isolated by exploiting combination cell adhesion magnetic bead...
Abstract Telocytes, newly discovered in the last decade, are interstitial cells found numerous organs, with multiple proposed potential biological functions. Toll‐like receptors (TLRs) play an important role innate and adaptive immunity by recognizing pathogen‐associated molecular patterns (PAMPs). However, it is still unknown whether telocytes express these receptors. We sought to determine expression of TLRs telocytes. In our study, we primarily detected TLR1‐9 The proliferation, apoptosis...
<p>Supplemental Materials and Methods Figure Legends</p>
<p>S. Fig. 7. Pam3CSK4 stimulation reduces MDSC number.</p>
<p>Supplemental Materials and Methods Figure Legends</p>
<p>S. Fig. 7. Pam3CSK4 stimulation reduces MDSC number.</p>
<div>Abstract<p>Immune mechanisms underlying hepatocellular carcinoma (HCC) are not well understood. Here, we show that the Toll-like receptor TLR2 inhibits production of proinflammatory cytokine IL18 and protects mice from DEN-induced liver carcinogenesis. On this protocol, <i>Tlr2</i><sup>−/−</sup> exhibited more aggressive HCC development associated with impaired CD8<sup>+</sup> T-cell function. Furthermore,...
<div>Abstract<p>Immune mechanisms underlying hepatocellular carcinoma (HCC) are not well understood. Here, we show that the Toll-like receptor TLR2 inhibits production of proinflammatory cytokine IL18 and protects mice from DEN-induced liver carcinogenesis. On this protocol, <i>Tlr2</i><sup>−/−</sup> exhibited more aggressive HCC development associated with impaired CD8<sup>+</sup> T-cell function. Furthermore,...