Ellen H. A. van den Munckhof

ORCID: 0000-0003-4100-4529
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About
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Research Areas
  • Reproductive tract infections research
  • Urinary Tract Infections Management
  • Pelvic floor disorders treatments
  • Dermatology and Skin Diseases
  • Urological Disorders and Treatments
  • Allergic Rhinitis and Sensitization
  • Urinary Bladder and Prostate Research
  • Genital Health and Disease
  • Urologic and reproductive health conditions
  • Asthma and respiratory diseases
  • Gut microbiota and health
  • Pneumonia and Respiratory Infections
  • Preterm Birth and Chorioamnionitis
  • Sinusitis and nasal conditions
  • Contact Dermatitis and Allergies
  • Reproductive Health and Contraception
  • Reproductive Physiology in Livestock
  • Syphilis Diagnosis and Treatment
  • Liver Disease Diagnosis and Treatment
  • Liver Disease and Transplantation
  • Otolaryngology and Infectious Diseases
  • Assisted Reproductive Technology and Twin Pregnancy
  • Bacterial Identification and Susceptibility Testing
  • Mycobacterium research and diagnosis
  • Streptococcal Infections and Treatments

DDL Diagnostic Laboratory
2018-2024

Tabriz University of Medical Sciences
2023

Leiden University Medical Center
2020

Omiganan is an indolicidin analog with antimicrobial properties that could be beneficial for patients atopic dermatitis. In this randomized, double-blind, placebo-controlled, phase II trial we explored the efficacy, pharmacodynamics, and safety of topical omiganan once daily in 36 mild to moderate atomic Patients were randomized apply 1%, 2.5%, or vehicle gel one target lesion 28 consecutive days. Small but significant improvements local objective SCORing Atopic Dematitis index morning itch...

10.1111/cts.12792 article EN cc-by-nc Clinical and Translational Science 2020-04-21

It has been hypothesized that the urinary microbiome might play an important role in OAB. Studies have conducted on association between OAB symptoms and microbiome, although a possible causality still to be determined.In this study, 12 female patients, ≥18 years of age, with 'OAB DO+' 9 patients DO-' were included. Patients excluded if they met one following exclusion criteria: bladder tumors previous operations; sacral neuromodulation; injection Botox bladder; TOT or TVT operations. Urine...

10.3390/life13051199 article EN cc-by Life 2023-05-17

Abstract Background The elderly (≥65 years) are one of the populations most at risk for respiratory tract infections (RTIs). aim this study was to determine whether nasal and/or oropharyngeal microbiota profiles associated with age and RTIs. Methods Nasal swabs 152 controls patients an RTI were included. latter group consisted 72 upper infection (URTI) 80 a lower (LRTI). Both subjected profiling using amplicon sequencing 16S rRNA gene. Moraxella species determined quantitative real-time PCR...

10.1186/s12931-020-01443-8 article EN cc-by Respiratory Research 2020-07-14

Abstract Background Male genital lichen sclerosus (MGLSc) is a chronic inflammatory scarring dermatosis associated with penile carcinoma. The prepuce pivotal in its etiology. Other proposed etiological factors are the subject of dispute and include occluded urinary exposure, autoimmunity, immunodysregulation, infectious agents. Objective To determine whether bacterial microbiota balanopreputial sac urine MGLSc. Subjects methods Twenty uncircumcised patients MGLSc 20 healthy males were...

10.1111/ijd.15252 article EN International Journal of Dermatology 2020-10-20

Abstract Bacterial vaginosis (BV) is perceived as a condition of disrupted vaginal microbiota, but remains unknown aetiology. In this study, microbiota composition was determined in twenty-one women with BV, before and after treatment metronidazole or clindamycin. Microbiota varied greatly between defining (un)healthy state elusive, challenging BV diagnosis treatment. While relative abundance Lactobacillus increased antibiotic two-third women, its not associated outcome. Instead, remaining...

10.1007/s10096-020-04049-6 article EN cc-by European Journal of Clinical Microbiology & Infectious Diseases 2020-10-07

Fig. 1.Lesional and non-lesional skin microbiota of 3 selected patients representing groups with different microbiological phenotypes shown in (a, b) principal coordinates analysis (PCoA) plots (c-h) bar charts.In the PCoA plots, arrows combined day numbers show how composition changed over time.

10.2340/00015555-3373 article EN cc-by-nc Acta Dermato Venereologica 2019-11-19

Abstract Small intestinal bacterial overgrowth and compositional changes of microbiota are pathomechanistic factors in liver cirrhosis leading to translocation infectious complications. We analyzed the quantity composition duodenal DNA (bactDNA) relation bactDNA blood ascites patients with cirrhosis. Duodenal fluid corresponding samples from 103 were collected. Non-liver disease (n = 22) served as controls. BactDNA was quantified by 16S-rRNA gene-based PCR. T-RFLP amplicon sequencing used...

10.1038/s41598-023-49505-3 article EN cc-by Scientific Reports 2023-12-27

Abstract This study aimed to investigate the influence of hormonal treatment on vaginal microbiome during fertility treatments. Bacterial vaginosis (BV) could affect fecundity, particularly in vitro fertilization (IVF) population, where negative effects pregnancy outcomes have been reported. It is hypothesized that hormone treatments abundance Lactobacilli , with results. A total 53 couples attending a clinic Netherlands between July 2019 and August 2022 were included this prospective cohort...

10.1007/s43032-024-01484-0 article EN cc-by Reproductive Sciences 2024-02-20

Abstract Purpose This study aimed to investigate the influence of bacterial vaginosis on time pregnancy in subfertile couples. Methods Couples attending a teaching hospital Netherlands having an initial fertility assessment (IFA) between July 2019 and June 2022 were included this prospective study, with follow-up pregnancies until 2023. Vaginal samples at IFA analyzed pH, qPCR BV, 16S rRNA gene microbiome analysis V1-V2 region. Main outcome measures from ongoing 12 weeks live birth, by...

10.1007/s00404-024-07542-x article EN cc-by Archives of Gynecology and Obstetrics 2024-05-16
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