A5053200679- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- IL-33, ST2, and ILC Pathways
- Organ Transplantation Techniques and Outcomes
- Diabetes and associated disorders
- Transplantation: Methods and Outcomes
- Organ and Tissue Transplantation Research
- Dermatology and Skin Diseases
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Blood groups and transfusion
- Inflammatory Bowel Disease
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Organ Donation and Transplantation
- Drug Transport and Resistance Mechanisms
- Immunotherapy and Immune Responses
- Metabolism and Genetic Disorders
- Hemoglobinopathies and Related Disorders
University of Debrecen
2022-2024
Background Given the physiological hemostasis changes during pregnancy, limited data exists on COVID-19-induced inflammatory response and alterations in pregnant women. Objectives To test a comprehensive set of cytokines pregnancies with/without COVID-19 correlate results with maternal perinatal outcomes. Patients/methods In this observational case-control study, 100 women acute at 24-40 gestational weeks (COVID-19+ group), healthy, age- week-matched, SARS-CoV-2 negative (32 proven recovery...
Abstract Unconventional T cells show distinct and unique features during antigen recognition as well other immune responses. Their decrease in frequency is associated with various autoimmune disorders, allergy, inflammation, cancer. The landscape of the unconventional altogether (iNKT, γδ T, MAIT) largely unestablished leading to challenges affecting diagnosis research this field. In study, we have established age group–wise iNKT, MAIT on a total 203 healthy adult samples Caucasian...
Background SARS-CoV-2 infection during pregnancy increases the risk of severe obstetrical complications. Detailed evaluation COVID-19-associated coagulopathy in a with stillbirth hasn’t been described so far. Besides knowledge gaps pathomechanism leading to COVID-19 pregnancies, currently, no prognostic biomarker is available identify pregnant patients who are at imminent maternal and fetal complications, requiring immediate medical attention. Case Here we report case 28-year-old infected...
This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161− in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate adaptive immunity, were analyzed alongside peripheral blood samples from 14 dermatitis patients 10 healthy controls. Flow cytometry machine learning algorithms employed a comprehensive analysis. The results indicate significant decrease CD69 subsets dermatitis, coupled with elevated CD38 polyfunctional...
Abstract This study tested the hypothesis of gender bias in frequency unconventional T cells. Unconventional cells exist as minor subsets peripheral blood. Despite their low number, they play a crucial role various immune-mediated diseases such inflammation, autoimmunity, allergy, and cancer. Gender-based these altogether on large number healthy individuals are unestablished creating hurdles to manifest association with pathologic conditions. In this study, we used multicolor flow cytometric...
Abstract As the association of human leukocyte antigen B27 (HLA‐B27) with spondylarthropathies is widely known, HLA‐B27 expression frequently identified using flow cytometric or other techniques. Because possibility cross‐reaction off target antigens, such as HLA‐B7, each technique applies a “gray zone” reserved for equivocal findings. Our aim was to use machine learning (ML) methods classify data positive negative. Equivocal samples ( n = 99) were selected from submitted our institution...
Mucosal-associated invariant T (MAIT) cells, a subset of Vα7.2+ are crucial link between innate and adaptive immunity, responding to various stimuli through TCR-dependent independent pathways. We investigated the responses MAIT cells Vα7.2+/CD161- different evaluated effects Cyclosporin A (CsA) Vitamin D3 (VitD). Peripheral blood mononuclear (PBMCs) from healthy donors were stimulated with agents (PMA/Ionomycin, 5-OP-RU, 5-OP-RU/IL-12/IL-33) or without CsA VitD. Flow cytometric analysis...
Background and Objectives Timely detection of human leucocyte antigen ( HLA ) antibodies plays a key part in transplant outcome. Conventionally, several cell‐based assays are available for upgrading to virtual crossmatch which single‐antigen bead SAB assay is widely used characterization pre‐formed donor‐specific DSA s). The main objective here find the prevalence specificity anti‐ Indian population using Luminex LSA assay. Materials Methods A total 179 patients included study analysing by...
In India, 90% kidneys for transplantation are obtained from living donor while only 10% come deceased donors. Since the rate of organ donors is high, it therefore leads to problem trafficking.To minimize chances trafficking, Transplantation Human Organ Act (THOA) 2014 was enacted in India that makes mandatory prove relationship between patient and by DNA testing. The present study undertaken evaluate degree matching maternally related patients donors, performed using mitochondrial...
Unconventional T cells exist as minor subsets of in peripheral blood. Despite their low number they play a crucial role various immune-mediated diseases such inflammation, autoimmunity, allergy, and cancer. Gender-based frequency these altogether on the large healthy individuals are unestablished creating hurdles to manifest association with pathological conditions. In this study, we used multicolor flow cytometric panel identify iNKT cells, γδ MAIT total 94 adult males (44 ± 14 years) 109...
Background: The understanding of transplant acceptance or rejection derives directly from knowing human leukocyte antigen (HLA) involved in the immune response. HLA major histocompatibility complex contains a numerous family genes located on short arm chromosome number 6 and divided majorly into two classes, Class I (HLA-A, B, C) II (HLA-DR, DQ, DP). detection detailed information these are essential for better outcome organ transplants. Aims Objectives: aim present study is to analyze...
Introduction: India has a huge disease burden of thalassemia major with an estimated 40 million carriers and over patients. Very few patients are optimally treated, the standard care “hematopoietic stem cell transplant” (HSCT) is out reach for most their families. The cost HSCT significant, substantial proportion it goes to human leukocyte antigen (HLA) testing family members (HLA screening) in hope getting matched related donor (MRD) HSCT. aim this study was establish that new proposed...
Human leukocyte antigen (HLA) is a major determinant in deciding upon solid organ histocompatibility. Donor-specific anti-HLA antibodies (Donor-specific (DSAs)) are always contraindication for transplantation, and identification of DSA becomes very crucial before transplantation to provide long-term graft survival. For DSA, usually, either cell-based or HLA bead-based assay being used laboratories. However, both assays have certain limitations. One such common limitation "prozone effect,"...