A5028141932- Malaria Research and Control
- Viral Infections and Vectors
- vaccines and immunoinformatics approaches
- Mosquito-borne diseases and control
- Drug-Induced Adverse Reactions
- Global Health and Epidemiology
- Zoonotic diseases and public health
- Virology and Viral Diseases
- Leptospirosis research and findings
- HIV/AIDS drug development and treatment
- Viral gastroenteritis research and epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Infection Control and Ventilation
- Influenza Virus Research Studies
- Respiratory viral infections research
- Child Nutrition and Water Access
- Pneumocystis jirovecii pneumonia detection and treatment
Naval Medical Research Command
2015-2025
Cambodia-Oxford Medical Research Unit
2023
Walter Reed National Military Medical Center
2015
Naval Medical Center San Diego
2011
Background A three-antigen DNA-prime/chimpanzee adenovirus 63 (ChAd63) boost vaccine containing pre-erythrocytic Plasmodium falciparum (Pf) circumsporozoite protein (CSP), Pf apical membrane antigen-1 (AMA1) and malaria multiple epitopes (ME) fused to thrombospondin-related adhesion (ME-TRAP) elicited higher efficacy (VE) in an open label, randomized Phase 1 trial against controlled human infection (CHMI) than the two-antigen DNA/Human Adenovirus 5 (HuAd5) CSP AMA1. The objective of this...
Dengue is a global health problem and the development of tetravalent dengue vaccine with durable protection high priority. A heterologous prime-boost strategy has advantage eliciting immune responses through different mechanisms therefore may be superior to homologous strategies for generating immunity.In this phase 1 first-in-human study, 80 volunteers were assigned 4 groups received virus (DENV-1-4) purified inactivated (TDENV-PIV) alum adjuvant live attenuated (TDENV-LAV) in orders dosing...
Background A DNA-prime/human adenovirus serotype 5 (HuAd5) boost vaccine encoding Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP) and Pf apical membrane antigen-1 (PfAMA1), elicited protection in 4/15 (27%) of subjects against controlled human malaria infection (CHMI) that was statistically associated with CD8+ T cell responses. Subjects high level pre-existing immunity to HuAd5 were not protected, suggesting an adverse effect on efficacy (VE). We replaced chimpanzee 63 (ChAd63),...
Diarrheal diseases are a leading cause of mortality and morbidity, disproportionally affecting persons residing in low middle-income countries. Accessing high-resolution surveillance data to understand community-level etiology risk remains challenging, particularly remote resource limited populations. A multi-year prospective cohort study was conducted two rural peri-urban villages Cambodia from 2012 2018 describe the epidemiology acute diarrheal within population. Suspected episodes among...
Adverse drug reactions (ADRs) to antibiotics complicate the management of any infection, particularly opportunistic infections in advanced HIV as some ADRs are potentiated by HIV. Trimethoprim-sulfamethoxazole (TMP-SMX) causes 40-80% infected individuals, compared 3-5% general population. The incidence and severity among individuals appear increase they progress from latent infection AIDS. We present a single case report 55-year-old African American male found have an otherwise asymptomatic...